| Full name: huntingtin interacting protein K | Alias Symbol: HSPC136|FLJ20431 | ||
| Type: protein-coding gene | Cytoband: 15q15.3 | ||
| Entrez ID: 25764 | HGNC ID: HGNC:18418 | Ensembl Gene: ENSG00000242028 | OMIM ID: 612784 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of HYPK:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HYPK | 25764 | 233809_at | 0.1481 | 0.5444 | |
| GSE26886 | HYPK | 25764 | 233809_at | 0.1716 | 0.3582 | |
| GSE45670 | HYPK | 25764 | 233809_at | 0.3319 | 0.0029 | |
| GSE63941 | HYPK | 25764 | 233809_at | 0.7367 | 0.0347 | |
| GSE77861 | HYPK | 25764 | 233809_at | 0.0941 | 0.6348 | |
| SRP007169 | HYPK | 25764 | RNAseq | 0.5583 | 0.4534 | |
| SRP064894 | HYPK | 25764 | RNAseq | 0.2080 | 0.2877 | |
| SRP133303 | HYPK | 25764 | RNAseq | -0.1097 | 0.3252 | |
| SRP159526 | HYPK | 25764 | RNAseq | 0.0263 | 0.9234 | |
| SRP193095 | HYPK | 25764 | RNAseq | 0.1341 | 0.2950 | |
| SRP219564 | HYPK | 25764 | RNAseq | -0.2734 | 0.2997 |
Upregulated datasets: 0; Downregulated datasets: 0.
Copy number change of HYPK:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HYPK | 25764 | 3 | 4 | 23 | |
| GSE20123 | HYPK | 25764 | 3 | 5 | 22 | |
| GSE43470 | HYPK | 25764 | 3 | 4 | 36 | |
| GSE46452 | HYPK | 25764 | 3 | 7 | 49 | |
| GSE47630 | HYPK | 25764 | 8 | 10 | 22 | |
| GSE54993 | HYPK | 25764 | 4 | 6 | 60 | |
| GSE54994 | HYPK | 25764 | 5 | 7 | 41 | |
| GSE60625 | HYPK | 25764 | 4 | 0 | 7 | |
| GSE74703 | HYPK | 25764 | 3 | 3 | 30 | |
| GSE74704 | HYPK | 25764 | 2 | 2 | 16 | |
| TCGA | HYPK | 25764 | 12 | 17 | 67 |
Total number of gains: 50; Total number of losses: 65; Total Number of normals: 373.
Somatic mutations of HYPK:
Generating mutation plots.
Highly correlated genes for HYPK:
Showing top 20/26 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HYPK | ZNF488 | 0.648948 | 3 | 0 | 3 |
| HYPK | C14orf178 | 0.620125 | 3 | 0 | 3 |
| HYPK | VWA3A | 0.617424 | 3 | 0 | 3 |
| HYPK | VPS9D1-AS1 | 0.613523 | 4 | 0 | 3 |
| HYPK | AUNIP | 0.612214 | 4 | 0 | 3 |
| HYPK | ZNF598 | 0.580356 | 3 | 0 | 3 |
| HYPK | CNGB3 | 0.570018 | 4 | 0 | 3 |
| HYPK | PTPN9 | 0.565085 | 4 | 0 | 3 |
| HYPK | FOSL1 | 0.56235 | 4 | 0 | 3 |
| HYPK | LINC00520 | 0.551817 | 5 | 0 | 3 |
| HYPK | FAM86C1 | 0.550438 | 4 | 0 | 3 |
| HYPK | SLC7A5 | 0.550187 | 4 | 0 | 3 |
| HYPK | OIP5 | 0.54772 | 4 | 0 | 3 |
| HYPK | FAM111B | 0.544638 | 4 | 0 | 3 |
| HYPK | PAM16 | 0.543939 | 5 | 0 | 3 |
| HYPK | LCE1E | 0.541211 | 4 | 0 | 3 |
| HYPK | RAB3IL1 | 0.541172 | 4 | 0 | 3 |
| HYPK | USP5 | 0.536948 | 3 | 0 | 3 |
| HYPK | LINC00942 | 0.536688 | 4 | 0 | 4 |
| HYPK | TAF1A-AS1 | 0.53384 | 3 | 0 | 3 |
For details and further investigation, click here
