| Full name: islet cell autoantigen 1 | Alias Symbol: ICAp69|ICA69 | ||
| Type: protein-coding gene | Cytoband: 7p21.3 | ||
| Entrez ID: 3382 | HGNC ID: HGNC:5343 | Ensembl Gene: ENSG00000003147 | OMIM ID: 147625 |
| Drug and gene relationship at DGIdb | |||
Expression of ICA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ICA1 | 3382 | 210547_x_at | -0.6471 | 0.2830 | |
| GSE20347 | ICA1 | 3382 | 210547_x_at | -0.9185 | 0.0000 | |
| GSE23400 | ICA1 | 3382 | 210547_x_at | -0.3803 | 0.0000 | |
| GSE26886 | ICA1 | 3382 | 210547_x_at | -0.2661 | 0.4419 | |
| GSE29001 | ICA1 | 3382 | 210547_x_at | -0.8112 | 0.0035 | |
| GSE38129 | ICA1 | 3382 | 210547_x_at | -0.7337 | 0.0001 | |
| GSE45670 | ICA1 | 3382 | 210547_x_at | -0.8871 | 0.0120 | |
| GSE53622 | ICA1 | 3382 | 61220 | -1.9222 | 0.0000 | |
| GSE53624 | ICA1 | 3382 | 81208 | -1.7847 | 0.0000 | |
| GSE63941 | ICA1 | 3382 | 210547_x_at | 1.6854 | 0.0759 | |
| GSE77861 | ICA1 | 3382 | 207949_s_at | -0.2293 | 0.2138 | |
| GSE97050 | ICA1 | 3382 | A_23_P215419 | 0.2943 | 0.2783 | |
| SRP007169 | ICA1 | 3382 | RNAseq | -1.3437 | 0.0943 | |
| SRP064894 | ICA1 | 3382 | RNAseq | -1.3061 | 0.0000 | |
| SRP133303 | ICA1 | 3382 | RNAseq | -1.9360 | 0.0000 | |
| SRP159526 | ICA1 | 3382 | RNAseq | -1.6930 | 0.0009 | |
| SRP193095 | ICA1 | 3382 | RNAseq | -1.0121 | 0.0070 | |
| SRP219564 | ICA1 | 3382 | RNAseq | -0.4614 | 0.5503 | |
| TCGA | ICA1 | 3382 | RNAseq | -1.1117 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by ICA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ICA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ICA1 | 3382 | 15 | 2 | 13 | |
| GSE20123 | ICA1 | 3382 | 15 | 2 | 13 | |
| GSE43470 | ICA1 | 3382 | 8 | 0 | 35 | |
| GSE46452 | ICA1 | 3382 | 11 | 1 | 47 | |
| GSE47630 | ICA1 | 3382 | 9 | 1 | 30 | |
| GSE54993 | ICA1 | 3382 | 0 | 6 | 64 | |
| GSE54994 | ICA1 | 3382 | 22 | 1 | 30 | |
| GSE60625 | ICA1 | 3382 | 0 | 0 | 11 | |
| GSE74703 | ICA1 | 3382 | 8 | 0 | 28 | |
| GSE74704 | ICA1 | 3382 | 9 | 2 | 9 | |
| TCGA | ICA1 | 3382 | 56 | 5 | 35 |
Total number of gains: 153; Total number of losses: 20; Total Number of normals: 315.
Somatic mutations of ICA1:
Generating mutation plots.
Highly correlated genes for ICA1:
Showing top 20/551 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ICA1 | FANCF | 0.702907 | 3 | 0 | 3 |
| ICA1 | KIAA1211L | 0.67734 | 6 | 0 | 5 |
| ICA1 | TMEM51-AS1 | 0.676396 | 3 | 0 | 3 |
| ICA1 | CCDC125 | 0.674761 | 6 | 0 | 5 |
| ICA1 | FAM219B | 0.671496 | 3 | 0 | 3 |
| ICA1 | BLNK | 0.670058 | 9 | 0 | 8 |
| ICA1 | FAM221A | 0.665874 | 5 | 0 | 4 |
| ICA1 | SLC37A1 | 0.663636 | 12 | 0 | 11 |
| ICA1 | MYO5C | 0.656719 | 11 | 0 | 9 |
| ICA1 | EPB41L3 | 0.651782 | 8 | 0 | 7 |
| ICA1 | YPEL3 | 0.649395 | 6 | 0 | 5 |
| ICA1 | SNORA68 | 0.645228 | 3 | 0 | 3 |
| ICA1 | FAM3B | 0.643905 | 7 | 0 | 5 |
| ICA1 | ARHGAP40 | 0.642136 | 3 | 0 | 3 |
| ICA1 | SPATA18 | 0.641553 | 5 | 0 | 4 |
| ICA1 | TNXB | 0.640971 | 3 | 0 | 3 |
| ICA1 | LYPLA2 | 0.639993 | 4 | 0 | 3 |
| ICA1 | SCNN1B | 0.636827 | 10 | 0 | 9 |
| ICA1 | FAM189A2 | 0.636596 | 10 | 0 | 10 |
| ICA1 | EYA2 | 0.633006 | 11 | 0 | 8 |
For details and further investigation, click here
