| Full name: ubiquitin protein ligase E3C | Alias Symbol: KIAA0010|KIAA10 | ||
| Type: protein-coding gene | Cytoband: 7q36.3 | ||
| Entrez ID: 9690 | HGNC ID: HGNC:16803 | Ensembl Gene: ENSG00000009335 | OMIM ID: 614454 |
| Drug and gene relationship at DGIdb | |||
Expression of UBE3C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UBE3C | 9690 | 201817_at | 0.3623 | 0.4881 | |
| GSE20347 | UBE3C | 9690 | 201817_at | 0.1855 | 0.2279 | |
| GSE23400 | UBE3C | 9690 | 201817_at | 0.5340 | 0.0000 | |
| GSE26886 | UBE3C | 9690 | 201817_at | -0.6576 | 0.0068 | |
| GSE29001 | UBE3C | 9690 | 201817_at | 0.5457 | 0.0367 | |
| GSE38129 | UBE3C | 9690 | 201817_at | 0.3189 | 0.0024 | |
| GSE45670 | UBE3C | 9690 | 201817_at | 0.4108 | 0.0134 | |
| GSE53622 | UBE3C | 9690 | 10281 | 0.1332 | 0.1143 | |
| GSE53624 | UBE3C | 9690 | 93081 | 0.2290 | 0.0023 | |
| GSE63941 | UBE3C | 9690 | 201817_at | -0.7819 | 0.0110 | |
| GSE77861 | UBE3C | 9690 | 201817_at | 0.5133 | 0.0105 | |
| GSE97050 | UBE3C | 9690 | A_24_P212443 | 0.1227 | 0.6268 | |
| SRP007169 | UBE3C | 9690 | RNAseq | 0.5152 | 0.1183 | |
| SRP008496 | UBE3C | 9690 | RNAseq | 0.6073 | 0.0020 | |
| SRP064894 | UBE3C | 9690 | RNAseq | 0.2935 | 0.1215 | |
| SRP133303 | UBE3C | 9690 | RNAseq | 0.4479 | 0.0006 | |
| SRP159526 | UBE3C | 9690 | RNAseq | -0.0655 | 0.8609 | |
| SRP193095 | UBE3C | 9690 | RNAseq | 0.2012 | 0.0335 | |
| SRP219564 | UBE3C | 9690 | RNAseq | -0.4221 | 0.0996 | |
| TCGA | UBE3C | 9690 | RNAseq | -0.0061 | 0.8991 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by UBE3C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UBE3C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UBE3C | 9690 | 4 | 3 | 23 | |
| GSE20123 | UBE3C | 9690 | 3 | 3 | 24 | |
| GSE43470 | UBE3C | 9690 | 2 | 5 | 36 | |
| GSE46452 | UBE3C | 9690 | 7 | 2 | 50 | |
| GSE47630 | UBE3C | 9690 | 6 | 9 | 25 | |
| GSE54993 | UBE3C | 9690 | 3 | 3 | 64 | |
| GSE54994 | UBE3C | 9690 | 6 | 8 | 39 | |
| GSE60625 | UBE3C | 9690 | 0 | 0 | 11 | |
| GSE74703 | UBE3C | 9690 | 2 | 4 | 30 | |
| GSE74704 | UBE3C | 9690 | 1 | 3 | 16 | |
| TCGA | UBE3C | 9690 | 27 | 25 | 44 |
Total number of gains: 61; Total number of losses: 65; Total Number of normals: 362.
Somatic mutations of UBE3C:
Generating mutation plots.
Highly correlated genes for UBE3C:
Showing top 20/590 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UBE3C | LETM2 | 0.809317 | 3 | 0 | 3 |
| UBE3C | THAP5 | 0.783577 | 3 | 0 | 3 |
| UBE3C | PRPF38B | 0.78122 | 3 | 0 | 3 |
| UBE3C | ZC3H7B | 0.777877 | 3 | 0 | 3 |
| UBE3C | TRAF3IP1 | 0.775847 | 3 | 0 | 3 |
| UBE3C | VPS26B | 0.774697 | 3 | 0 | 3 |
| UBE3C | PRDM10 | 0.765685 | 3 | 0 | 3 |
| UBE3C | SLC25A3 | 0.76462 | 3 | 0 | 3 |
| UBE3C | MRPL37 | 0.755432 | 3 | 0 | 3 |
| UBE3C | EIF3I | 0.754624 | 3 | 0 | 3 |
| UBE3C | TAS2R19 | 0.737567 | 3 | 0 | 3 |
| UBE3C | RPUSD4 | 0.737165 | 3 | 0 | 3 |
| UBE3C | UBE2Z | 0.735669 | 5 | 0 | 4 |
| UBE3C | CPT1A | 0.73482 | 3 | 0 | 3 |
| UBE3C | ATG4C | 0.734562 | 3 | 0 | 3 |
| UBE3C | TMEM218 | 0.733481 | 3 | 0 | 3 |
| UBE3C | MOB3C | 0.732239 | 3 | 0 | 3 |
| UBE3C | MGAT4B | 0.725011 | 3 | 0 | 3 |
| UBE3C | EIF3A | 0.724906 | 3 | 0 | 3 |
| UBE3C | GOLGA3 | 0.724656 | 3 | 0 | 3 |
For details and further investigation, click here
