| Full name: inducible T cell costimulator | Alias Symbol: AILIM|CD278 | ||
| Type: protein-coding gene | Cytoband: 2q33.2 | ||
| Entrez ID: 29851 | HGNC ID: HGNC:5351 | Ensembl Gene: ENSG00000163600 | OMIM ID: 604558 |
| Drug and gene relationship at DGIdb | |||
ICOS involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04660 | T cell receptor signaling pathway |
Expression of ICOS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ICOS | 29851 | 210439_at | 0.4861 | 0.3586 | |
| GSE20347 | ICOS | 29851 | 210439_at | 0.1730 | 0.0605 | |
| GSE23400 | ICOS | 29851 | 210439_at | 0.0224 | 0.5244 | |
| GSE26886 | ICOS | 29851 | 210439_at | -0.4388 | 0.1775 | |
| GSE29001 | ICOS | 29851 | 210439_at | 0.5692 | 0.0393 | |
| GSE38129 | ICOS | 29851 | 210439_at | 0.2321 | 0.0809 | |
| GSE45670 | ICOS | 29851 | 210439_at | 0.6427 | 0.0021 | |
| GSE63941 | ICOS | 29851 | 210439_at | 0.0424 | 0.8349 | |
| GSE77861 | ICOS | 29851 | 210439_at | -0.1720 | 0.1887 | |
| GSE97050 | ICOS | 29851 | A_23_P371215 | 0.4425 | 0.1806 | |
| SRP007169 | ICOS | 29851 | RNAseq | 2.1340 | 0.0325 | |
| SRP133303 | ICOS | 29851 | RNAseq | 1.1178 | 0.0075 | |
| SRP159526 | ICOS | 29851 | RNAseq | 0.0961 | 0.9219 | |
| SRP193095 | ICOS | 29851 | RNAseq | 0.7947 | 0.0093 | |
| SRP219564 | ICOS | 29851 | RNAseq | 1.6082 | 0.0696 | |
| TCGA | ICOS | 29851 | RNAseq | 1.5254 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by ICOS expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ICOS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ICOS | 29851 | 6 | 4 | 20 | |
| GSE20123 | ICOS | 29851 | 6 | 4 | 20 | |
| GSE43470 | ICOS | 29851 | 1 | 4 | 38 | |
| GSE46452 | ICOS | 29851 | 1 | 4 | 54 | |
| GSE47630 | ICOS | 29851 | 4 | 5 | 31 | |
| GSE54993 | ICOS | 29851 | 0 | 3 | 67 | |
| GSE54994 | ICOS | 29851 | 10 | 8 | 35 | |
| GSE60625 | ICOS | 29851 | 0 | 3 | 8 | |
| GSE74703 | ICOS | 29851 | 1 | 3 | 32 | |
| GSE74704 | ICOS | 29851 | 3 | 2 | 15 | |
| TCGA | ICOS | 29851 | 19 | 14 | 63 |
Total number of gains: 51; Total number of losses: 54; Total Number of normals: 383.
Somatic mutations of ICOS:
Generating mutation plots.
Highly correlated genes for ICOS:
Showing top 20/201 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ICOS | TNFRSF9 | 0.685413 | 6 | 0 | 5 |
| ICOS | CCR5 | 0.665752 | 8 | 0 | 7 |
| ICOS | ZNFX1 | 0.662761 | 3 | 0 | 3 |
| ICOS | CD300A | 0.657326 | 9 | 0 | 8 |
| ICOS | CYTIP | 0.654198 | 8 | 0 | 8 |
| ICOS | EVI2B | 0.652588 | 8 | 0 | 7 |
| ICOS | TFEC | 0.650717 | 8 | 0 | 7 |
| ICOS | THEMIS2 | 0.637527 | 7 | 0 | 6 |
| ICOS | IGSF6 | 0.635866 | 9 | 0 | 7 |
| ICOS | GMFG | 0.63493 | 8 | 0 | 7 |
| ICOS | CD53 | 0.63004 | 10 | 0 | 7 |
| ICOS | IL10RA | 0.629376 | 8 | 0 | 6 |
| ICOS | GZMB | 0.628632 | 9 | 0 | 7 |
| ICOS | ARHGAP4 | 0.627808 | 4 | 0 | 4 |
| ICOS | ZC3H12D | 0.626982 | 3 | 0 | 3 |
| ICOS | TNFRSF1B | 0.626885 | 9 | 0 | 7 |
| ICOS | CXCL11 | 0.6267 | 9 | 0 | 7 |
| ICOS | APOBEC3B | 0.625136 | 4 | 0 | 4 |
| ICOS | ITGB2-AS1 | 0.624512 | 3 | 0 | 3 |
| ICOS | KMO | 0.623645 | 5 | 0 | 4 |
For details and further investigation, click here
