| Full name: apolipoprotein B mRNA editing enzyme catalytic subunit 3B | Alias Symbol: PHRBNL|FLJ21201 | ||
| Type: protein-coding gene | Cytoband: 22q13.1 | ||
| Entrez ID: 9582 | HGNC ID: HGNC:17352 | Ensembl Gene: ENSG00000179750 | OMIM ID: 607110 |
| Drug and gene relationship at DGIdb | |||
Expression of APOBEC3B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | APOBEC3B | 9582 | 206632_s_at | 1.9250 | 0.0286 | |
| GSE20347 | APOBEC3B | 9582 | 206632_s_at | 2.9698 | 0.0000 | |
| GSE23400 | APOBEC3B | 9582 | 206632_s_at | 1.2539 | 0.0000 | |
| GSE26886 | APOBEC3B | 9582 | 206632_s_at | 2.7695 | 0.0000 | |
| GSE29001 | APOBEC3B | 9582 | 206632_s_at | 2.9404 | 0.0000 | |
| GSE38129 | APOBEC3B | 9582 | 206632_s_at | 3.1304 | 0.0000 | |
| GSE45670 | APOBEC3B | 9582 | 206632_s_at | 3.7536 | 0.0000 | |
| GSE53622 | APOBEC3B | 9582 | 143500 | 2.0042 | 0.0000 | |
| GSE53624 | APOBEC3B | 9582 | 143500 | 1.7123 | 0.0000 | |
| GSE63941 | APOBEC3B | 9582 | 206632_s_at | 3.0418 | 0.1491 | |
| GSE77861 | APOBEC3B | 9582 | 206632_s_at | 2.1765 | 0.0195 | |
| GSE97050 | APOBEC3B | 9582 | A_24_P66027 | 1.9556 | 0.0871 | |
| SRP007169 | APOBEC3B | 9582 | RNAseq | 3.6262 | 0.0000 | |
| SRP133303 | APOBEC3B | 9582 | RNAseq | 2.3805 | 0.0000 | |
| SRP159526 | APOBEC3B | 9582 | RNAseq | 2.5459 | 0.0000 | |
| SRP219564 | APOBEC3B | 9582 | RNAseq | 3.1381 | 0.0034 | |
| TCGA | APOBEC3B | 9582 | RNAseq | 1.1533 | 0.0000 |
Upregulated datasets: 15; Downregulated datasets: 0.
Survival by APOBEC3B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of APOBEC3B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | APOBEC3B | 9582 | 6 | 5 | 19 | |
| GSE20123 | APOBEC3B | 9582 | 6 | 4 | 20 | |
| GSE43470 | APOBEC3B | 9582 | 5 | 5 | 33 | |
| GSE46452 | APOBEC3B | 9582 | 32 | 2 | 25 | |
| GSE47630 | APOBEC3B | 9582 | 9 | 4 | 27 | |
| GSE54993 | APOBEC3B | 9582 | 3 | 6 | 61 | |
| GSE54994 | APOBEC3B | 9582 | 9 | 7 | 37 | |
| GSE60625 | APOBEC3B | 9582 | 5 | 0 | 6 | |
| GSE74703 | APOBEC3B | 9582 | 5 | 4 | 27 | |
| GSE74704 | APOBEC3B | 9582 | 3 | 2 | 15 | |
| TCGA | APOBEC3B | 9582 | 27 | 15 | 54 |
Total number of gains: 110; Total number of losses: 54; Total Number of normals: 324.
Somatic mutations of APOBEC3B:
Generating mutation plots.
Highly correlated genes for APOBEC3B:
Showing top 20/1629 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| APOBEC3B | B3GALT6 | 0.759249 | 4 | 0 | 4 |
| APOBEC3B | TMEM132A | 0.737623 | 8 | 0 | 7 |
| APOBEC3B | NEK6 | 0.731113 | 4 | 0 | 4 |
| APOBEC3B | COMMD2 | 0.724767 | 3 | 0 | 3 |
| APOBEC3B | ADAMTSL2 | 0.72213 | 3 | 0 | 3 |
| APOBEC3B | MMP12 | 0.721533 | 11 | 0 | 11 |
| APOBEC3B | MET | 0.712604 | 10 | 0 | 9 |
| APOBEC3B | SLC37A3 | 0.710426 | 3 | 0 | 3 |
| APOBEC3B | XPR1 | 0.703161 | 7 | 0 | 6 |
| APOBEC3B | PREX1 | 0.700024 | 3 | 0 | 3 |
| APOBEC3B | CIC | 0.698777 | 4 | 0 | 4 |
| APOBEC3B | C12orf75 | 0.690447 | 6 | 0 | 6 |
| APOBEC3B | ARPC1B | 0.69007 | 11 | 0 | 10 |
| APOBEC3B | CHTF18 | 0.689166 | 4 | 0 | 4 |
| APOBEC3B | CLIC4 | 0.688524 | 5 | 0 | 4 |
| APOBEC3B | HAS3 | 0.687259 | 5 | 0 | 5 |
| APOBEC3B | PLEKHA3 | 0.685883 | 3 | 0 | 3 |
| APOBEC3B | ECT2 | 0.685437 | 10 | 0 | 10 |
| APOBEC3B | C14orf119 | 0.685347 | 3 | 0 | 3 |
| APOBEC3B | RNF166 | 0.683757 | 3 | 0 | 3 |
For details and further investigation, click here
