| Full name: kynurenine 3-monooxygenase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q43 | ||
| Entrez ID: 8564 | HGNC ID: HGNC:6381 | Ensembl Gene: ENSG00000117009 | OMIM ID: 603538 |
| Drug and gene relationship at DGIdb | |||
Expression of KMO:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KMO | 8564 | 205306_x_at | 0.8333 | 0.1308 | |
| GSE20347 | KMO | 8564 | 211138_s_at | 0.1844 | 0.0433 | |
| GSE23400 | KMO | 8564 | 211138_s_at | -0.1671 | 0.0023 | |
| GSE26886 | KMO | 8564 | 205306_x_at | 0.3817 | 0.1080 | |
| GSE29001 | KMO | 8564 | 205306_x_at | 0.2890 | 0.1695 | |
| GSE38129 | KMO | 8564 | 211138_s_at | 0.2779 | 0.0207 | |
| GSE45670 | KMO | 8564 | 205306_x_at | 0.8640 | 0.0031 | |
| GSE53622 | KMO | 8564 | 80437 | 0.0792 | 0.2214 | |
| GSE53624 | KMO | 8564 | 80437 | 0.1644 | 0.0189 | |
| GSE63941 | KMO | 8564 | 211138_s_at | 1.3270 | 0.1889 | |
| GSE77861 | KMO | 8564 | 205306_x_at | 0.0265 | 0.8141 | |
| GSE97050 | KMO | 8564 | A_23_P200838 | 0.4444 | 0.1623 | |
| SRP064894 | KMO | 8564 | RNAseq | 1.4659 | 0.0000 | |
| SRP133303 | KMO | 8564 | RNAseq | 0.3042 | 0.1059 | |
| SRP159526 | KMO | 8564 | RNAseq | 0.0535 | 0.8924 | |
| SRP193095 | KMO | 8564 | RNAseq | 0.5329 | 0.0001 | |
| SRP219564 | KMO | 8564 | RNAseq | 1.2612 | 0.0201 | |
| TCGA | KMO | 8564 | RNAseq | 0.6720 | 0.0093 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by KMO expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KMO:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KMO | 8564 | 7 | 1 | 22 | |
| GSE20123 | KMO | 8564 | 7 | 1 | 22 | |
| GSE43470 | KMO | 8564 | 6 | 1 | 36 | |
| GSE46452 | KMO | 8564 | 4 | 2 | 53 | |
| GSE47630 | KMO | 8564 | 15 | 0 | 25 | |
| GSE54993 | KMO | 8564 | 0 | 6 | 64 | |
| GSE54994 | KMO | 8564 | 18 | 0 | 35 | |
| GSE60625 | KMO | 8564 | 0 | 0 | 11 | |
| GSE74703 | KMO | 8564 | 6 | 1 | 29 | |
| GSE74704 | KMO | 8564 | 2 | 0 | 18 | |
| TCGA | KMO | 8564 | 43 | 4 | 49 |
Total number of gains: 108; Total number of losses: 16; Total Number of normals: 364.
Somatic mutations of KMO:
Generating mutation plots.
Highly correlated genes for KMO:
Showing top 20/175 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KMO | FERMT3 | 0.702359 | 3 | 0 | 3 |
| KMO | DMC1 | 0.681367 | 3 | 0 | 3 |
| KMO | SEC14L4 | 0.680202 | 3 | 0 | 3 |
| KMO | CRYGC | 0.661608 | 3 | 0 | 3 |
| KMO | RNF17 | 0.642393 | 3 | 0 | 3 |
| KMO | MYO10 | 0.640629 | 3 | 0 | 3 |
| KMO | PLA2G7 | 0.638971 | 6 | 0 | 5 |
| KMO | FAM178B | 0.637985 | 3 | 0 | 3 |
| KMO | RUNX1-IT1 | 0.636545 | 4 | 0 | 3 |
| KMO | FCGR1B | 0.636249 | 6 | 0 | 6 |
| KMO | TRH | 0.635063 | 3 | 0 | 3 |
| KMO | HOMER3 | 0.631651 | 4 | 0 | 3 |
| KMO | SLC7A7 | 0.627005 | 6 | 0 | 5 |
| KMO | TAS2R3 | 0.624215 | 4 | 0 | 4 |
| KMO | ICOS | 0.623645 | 5 | 0 | 4 |
| KMO | CPN1 | 0.619491 | 4 | 0 | 3 |
| KMO | PARP10 | 0.617888 | 4 | 0 | 4 |
| KMO | MZB1 | 0.615791 | 4 | 0 | 4 |
| KMO | CD72 | 0.61381 | 5 | 0 | 3 |
| KMO | TCOF1 | 0.6127 | 4 | 0 | 3 |
For details and further investigation, click here
