| Full name: transient receptor potential cation channel subfamily M member 6 | Alias Symbol: CHAK2|FLJ22628 | ||
| Type: protein-coding gene | Cytoband: 9q21.13 | ||
| Entrez ID: 140803 | HGNC ID: HGNC:17995 | Ensembl Gene: ENSG00000119121 | OMIM ID: 607009 |
| Drug and gene relationship at DGIdb | |||
Expression of TRPM6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRPM6 | 140803 | 234864_s_at | -0.0170 | 0.9599 | |
| GSE20347 | TRPM6 | 140803 | 221102_s_at | 0.0362 | 0.6812 | |
| GSE23400 | TRPM6 | 140803 | 221102_s_at | 0.0155 | 0.7795 | |
| GSE26886 | TRPM6 | 140803 | 240389_at | -0.2406 | 0.0556 | |
| GSE29001 | TRPM6 | 140803 | 221102_s_at | -0.0307 | 0.8695 | |
| GSE38129 | TRPM6 | 140803 | 221102_s_at | 0.0001 | 0.9990 | |
| GSE45670 | TRPM6 | 140803 | 221102_s_at | 0.1736 | 0.0681 | |
| GSE53622 | TRPM6 | 140803 | 84221 | -1.0594 | 0.0000 | |
| GSE53624 | TRPM6 | 140803 | 84221 | -0.4418 | 0.0116 | |
| GSE63941 | TRPM6 | 140803 | 234864_s_at | 0.1944 | 0.1955 | |
| GSE77861 | TRPM6 | 140803 | 221102_s_at | 0.1212 | 0.3634 | |
| GSE97050 | TRPM6 | 140803 | A_24_P26792 | -0.0197 | 0.9649 | |
| SRP007169 | TRPM6 | 140803 | RNAseq | 0.9118 | 0.2222 | |
| SRP133303 | TRPM6 | 140803 | RNAseq | -0.0684 | 0.8252 | |
| SRP159526 | TRPM6 | 140803 | RNAseq | -0.4547 | 0.2961 | |
| SRP193095 | TRPM6 | 140803 | RNAseq | -0.0224 | 0.8985 | |
| SRP219564 | TRPM6 | 140803 | RNAseq | -0.2524 | 0.6744 | |
| TCGA | TRPM6 | 140803 | RNAseq | 0.1278 | 0.7131 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by TRPM6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRPM6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRPM6 | 140803 | 6 | 10 | 14 | |
| GSE20123 | TRPM6 | 140803 | 6 | 10 | 14 | |
| GSE43470 | TRPM6 | 140803 | 6 | 5 | 32 | |
| GSE46452 | TRPM6 | 140803 | 6 | 14 | 39 | |
| GSE47630 | TRPM6 | 140803 | 1 | 18 | 21 | |
| GSE54993 | TRPM6 | 140803 | 4 | 1 | 65 | |
| GSE54994 | TRPM6 | 140803 | 4 | 13 | 36 | |
| GSE60625 | TRPM6 | 140803 | 0 | 0 | 11 | |
| GSE74703 | TRPM6 | 140803 | 5 | 4 | 27 | |
| GSE74704 | TRPM6 | 140803 | 3 | 7 | 10 | |
| TCGA | TRPM6 | 140803 | 20 | 28 | 48 |
Total number of gains: 61; Total number of losses: 110; Total Number of normals: 317.
Somatic mutations of TRPM6:
Generating mutation plots.
Highly correlated genes for TRPM6:
Showing top 20/505 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRPM6 | NPFF | 0.788323 | 3 | 0 | 3 |
| TRPM6 | THSD7A | 0.770844 | 3 | 0 | 3 |
| TRPM6 | ABHD1 | 0.735251 | 3 | 0 | 3 |
| TRPM6 | KCND3 | 0.70878 | 3 | 0 | 3 |
| TRPM6 | TEAD4 | 0.704829 | 3 | 0 | 3 |
| TRPM6 | RFX1 | 0.700409 | 3 | 0 | 3 |
| TRPM6 | FZR1 | 0.693232 | 3 | 0 | 3 |
| TRPM6 | HOXB4 | 0.692535 | 3 | 0 | 3 |
| TRPM6 | GSTA3 | 0.685081 | 4 | 0 | 4 |
| TRPM6 | CD163L1 | 0.685076 | 3 | 0 | 3 |
| TRPM6 | C11orf68 | 0.679115 | 4 | 0 | 3 |
| TRPM6 | WASF2 | 0.672463 | 4 | 0 | 3 |
| TRPM6 | TMEM173 | 0.671616 | 3 | 0 | 3 |
| TRPM6 | TMEM214 | 0.668822 | 4 | 0 | 4 |
| TRPM6 | RNF214 | 0.668549 | 4 | 0 | 3 |
| TRPM6 | BCAS4 | 0.660922 | 3 | 0 | 3 |
| TRPM6 | IKBKG | 0.660202 | 4 | 0 | 4 |
| TRPM6 | IL18BP | 0.658284 | 4 | 0 | 4 |
| TRPM6 | LMAN1 | 0.657938 | 4 | 0 | 4 |
| TRPM6 | TTLL10 | 0.656861 | 3 | 0 | 3 |
For details and further investigation, click here
