IL10

 

Full name: interleukin 10 Alias Symbol: CSIF|TGIF|IL10A|IL-10
Type: protein-coding gene Cytoband: 1q32.1
Entrez ID: 3586 HGNC ID: HGNC:5962 Ensembl Gene: ENSG00000136634 OMIM ID: 124092
Drug and gene relationship at DGIdb

 

IL10 involved pathways:

KEGG pathway Description View
hsa04068FoxO signaling pathway
hsa04630Jak-STAT signaling pathway
hsa05140Leishmaniasis
hsa05142Chagas disease (American trypanosomiasis)
hsa05150Staphylococcus aureus infection
hsa05152Tuberculosis
hsa05321Inflammatory bowel disease (IBD)

 

Expression of IL10:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IL10 3586 207433_at 0.1935 0.5516
GSE20347 IL10 3586 207433_at 0.0463 0.3539
GSE23400 IL10 3586 207433_at -0.0719 0.0070
GSE26886 IL10 3586 207433_at -0.0087 0.9546
GSE29001 IL10 3586 207433_at 0.1008 0.3579
GSE38129 IL10 3586 207433_at 0.0701 0.1507
GSE45670 IL10 3586 207433_at 0.1291 0.3744
GSE53622 IL10 3586 82677 0.5856 0.0020
GSE53624 IL10 3586 86113 0.4636 0.0011
GSE63941 IL10 3586 207433_at 0.0823 0.5541
GSE77861 IL10 3586 207433_at 0.0010 0.9922
GSE97050 IL10 3586 A_23_P126735 0.2671 0.2120
SRP064894 IL10 3586 RNAseq 0.5261 0.1202
SRP133303 IL10 3586 RNAseq 0.4114 0.0662
SRP193095 IL10 3586 RNAseq 0.9535 0.0000
SRP219564 IL10 3586 RNAseq 1.5618 0.0677
TCGA IL10 3586 RNAseq 0.4651 0.1359

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by IL10 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IL10:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IL10 3586 11 0 19
GSE20123 IL10 3586 11 0 19
GSE43470 IL10 3586 7 0 36
GSE46452 IL10 3586 3 1 55
GSE47630 IL10 3586 14 0 26
GSE54993 IL10 3586 0 6 64
GSE54994 IL10 3586 14 0 39
GSE60625 IL10 3586 0 0 11
GSE74703 IL10 3586 7 0 29
GSE74704 IL10 3586 5 0 15
TCGA IL10 3586 44 4 48

Total number of gains: 116; Total number of losses: 11; Total Number of normals: 361.  

 

Somatic mutations of IL10:

 

Generating mutation plots.

 

Highly correlated genes for IL10:

 

Showing top 20/184 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IL10RGS30.664519505
IL10CCL30.638051303
IL10CMTM20.631108403
IL10DACT10.628636504
IL10NRROS0.626634303
IL10PLXNC10.620943504
IL10CEP1200.620701303
IL10CD1010.616774403
IL10LINC014490.614346303
IL10ADAMTS160.613959303
IL10GDF90.608566403
IL10C5AR10.600698704
IL10FNDC10.597536403
IL10GREM10.596582403
IL10C1orf2160.593904403
IL10IFNA70.593336403
IL10SRGN0.590298603
IL10LHFPL20.5898604
IL10FCGR3B0.589569403
IL10GPR650.588161503

For details and further investigation, click here