| Full name: gremlin 1, DAN family BMP antagonist | Alias Symbol: DRM|gremlin|DAND2|HMPS | ||
| Type: protein-coding gene | Cytoband: 15q13.3 | ||
| Entrez ID: 26585 | HGNC ID: HGNC:2001 | Ensembl Gene: ENSG00000166923 | OMIM ID: 603054 |
| Drug and gene relationship at DGIdb | |||
Expression of GREM1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GREM1 | 26585 | 218469_at | 0.3375 | 0.7108 | |
| GSE20347 | GREM1 | 26585 | 218469_at | 1.6974 | 0.0052 | |
| GSE23400 | GREM1 | 26585 | 218469_at | 1.1868 | 0.0001 | |
| GSE26886 | GREM1 | 26585 | 218469_at | 3.4741 | 0.0001 | |
| GSE29001 | GREM1 | 26585 | 218469_at | 1.4488 | 0.0574 | |
| GSE38129 | GREM1 | 26585 | 218469_at | 1.2351 | 0.0257 | |
| GSE45670 | GREM1 | 26585 | 218469_at | -1.0867 | 0.2866 | |
| GSE53622 | GREM1 | 26585 | 55847 | 0.4697 | 0.0086 | |
| GSE53624 | GREM1 | 26585 | 55847 | 0.7425 | 0.0000 | |
| GSE63941 | GREM1 | 26585 | 218468_s_at | -9.5921 | 0.0000 | |
| GSE77861 | GREM1 | 26585 | 218468_s_at | 1.6101 | 0.0721 | |
| GSE97050 | GREM1 | 26585 | A_33_P3319870 | 0.9660 | 0.1801 | |
| SRP007169 | GREM1 | 26585 | RNAseq | 5.4654 | 0.0000 | |
| SRP008496 | GREM1 | 26585 | RNAseq | 6.6695 | 0.0000 | |
| SRP064894 | GREM1 | 26585 | RNAseq | 1.5397 | 0.0003 | |
| SRP133303 | GREM1 | 26585 | RNAseq | 1.7370 | 0.0001 | |
| SRP159526 | GREM1 | 26585 | RNAseq | 0.2631 | 0.7445 | |
| SRP193095 | GREM1 | 26585 | RNAseq | 3.0614 | 0.0000 | |
| SRP219564 | GREM1 | 26585 | RNAseq | 2.4970 | 0.0023 | |
| TCGA | GREM1 | 26585 | RNAseq | -0.0731 | 0.5717 |
Upregulated datasets: 10; Downregulated datasets: 1.
Survival by GREM1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GREM1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GREM1 | 26585 | 2 | 7 | 21 | |
| GSE20123 | GREM1 | 26585 | 2 | 7 | 21 | |
| GSE43470 | GREM1 | 26585 | 4 | 4 | 35 | |
| GSE46452 | GREM1 | 26585 | 3 | 7 | 49 | |
| GSE47630 | GREM1 | 26585 | 8 | 11 | 21 | |
| GSE54993 | GREM1 | 26585 | 4 | 6 | 60 | |
| GSE54994 | GREM1 | 26585 | 5 | 8 | 40 | |
| GSE60625 | GREM1 | 26585 | 4 | 0 | 7 | |
| GSE74703 | GREM1 | 26585 | 4 | 3 | 29 | |
| GSE74704 | GREM1 | 26585 | 1 | 6 | 13 | |
| TCGA | GREM1 | 26585 | 13 | 17 | 66 |
Total number of gains: 50; Total number of losses: 76; Total Number of normals: 362.
Somatic mutations of GREM1:
Generating mutation plots.
Highly correlated genes for GREM1:
Showing top 20/603 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GREM1 | C11orf96 | 0.836616 | 3 | 0 | 3 |
| GREM1 | FBN1 | 0.805271 | 10 | 0 | 10 |
| GREM1 | NBPF20 | 0.804159 | 3 | 0 | 3 |
| GREM1 | COL6A3 | 0.79594 | 13 | 0 | 13 |
| GREM1 | CTSK | 0.77787 | 13 | 0 | 13 |
| GREM1 | VCAN | 0.772373 | 13 | 0 | 13 |
| GREM1 | FN1 | 0.766208 | 12 | 0 | 12 |
| GREM1 | COL8A1 | 0.754273 | 10 | 0 | 9 |
| GREM1 | NID2 | 0.746997 | 10 | 0 | 10 |
| GREM1 | FSTL1 | 0.739146 | 12 | 0 | 12 |
| GREM1 | PPP1R14A | 0.734965 | 3 | 0 | 3 |
| GREM1 | RARRES2 | 0.731171 | 13 | 0 | 13 |
| GREM1 | LUM | 0.730988 | 13 | 0 | 13 |
| GREM1 | SPARC | 0.725147 | 13 | 0 | 12 |
| GREM1 | MMP2 | 0.722334 | 12 | 0 | 10 |
| GREM1 | CHN1 | 0.721061 | 12 | 0 | 11 |
| GREM1 | FILIP1L | 0.720413 | 12 | 0 | 10 |
| GREM1 | FNDC1 | 0.718686 | 8 | 0 | 7 |
| GREM1 | COL3A1 | 0.715569 | 13 | 0 | 12 |
| GREM1 | COL1A2 | 0.714761 | 13 | 0 | 11 |
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