| Full name: ADAM metallopeptidase with thrombospondin type 1 motif 16 | Alias Symbol: ADAMTS16s | ||
| Type: protein-coding gene | Cytoband: 5p15.32 | ||
| Entrez ID: 170690 | HGNC ID: HGNC:17108 | Ensembl Gene: ENSG00000145536 | OMIM ID: 607510 |
| Drug and gene relationship at DGIdb | |||
Expression of ADAMTS16:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADAMTS16 | 170690 | 238125_at | -0.0208 | 0.9518 | |
| GSE26886 | ADAMTS16 | 170690 | 238125_at | -0.1929 | 0.0751 | |
| GSE45670 | ADAMTS16 | 170690 | 238125_at | -0.3976 | 0.0025 | |
| GSE53622 | ADAMTS16 | 170690 | 92745 | 1.0928 | 0.0000 | |
| GSE53624 | ADAMTS16 | 170690 | 92745 | 1.5069 | 0.0000 | |
| GSE63941 | ADAMTS16 | 170690 | 238125_at | 0.1312 | 0.6868 | |
| GSE77861 | ADAMTS16 | 170690 | 238125_at | -0.2494 | 0.1235 | |
| SRP007169 | ADAMTS16 | 170690 | RNAseq | 5.8002 | 0.0000 | |
| SRP133303 | ADAMTS16 | 170690 | RNAseq | 2.4161 | 0.0000 | |
| SRP219564 | ADAMTS16 | 170690 | RNAseq | 2.1817 | 0.0624 | |
| TCGA | ADAMTS16 | 170690 | RNAseq | -0.3321 | 0.4335 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by ADAMTS16 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADAMTS16:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADAMTS16 | 170690 | 13 | 0 | 17 | |
| GSE20123 | ADAMTS16 | 170690 | 13 | 0 | 17 | |
| GSE43470 | ADAMTS16 | 170690 | 17 | 0 | 26 | |
| GSE46452 | ADAMTS16 | 170690 | 6 | 22 | 31 | |
| GSE47630 | ADAMTS16 | 170690 | 6 | 11 | 23 | |
| GSE54993 | ADAMTS16 | 170690 | 5 | 5 | 60 | |
| GSE54994 | ADAMTS16 | 170690 | 29 | 1 | 23 | |
| GSE60625 | ADAMTS16 | 170690 | 0 | 0 | 11 | |
| GSE74703 | ADAMTS16 | 170690 | 13 | 0 | 23 | |
| GSE74704 | ADAMTS16 | 170690 | 11 | 0 | 9 | |
| TCGA | ADAMTS16 | 170690 | 57 | 5 | 34 |
Total number of gains: 170; Total number of losses: 44; Total Number of normals: 274.
Somatic mutations of ADAMTS16:
Generating mutation plots.
Highly correlated genes for ADAMTS16:
Showing top 20/70 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADAMTS16 | DACT1 | 0.664792 | 3 | 0 | 3 |
| ADAMTS16 | SFRP4 | 0.657863 | 3 | 0 | 3 |
| ADAMTS16 | PDGFRL | 0.649575 | 4 | 0 | 3 |
| ADAMTS16 | L1CAM | 0.630491 | 3 | 0 | 3 |
| ADAMTS16 | GPC6 | 0.625569 | 3 | 0 | 3 |
| ADAMTS16 | RARRES2 | 0.622086 | 3 | 0 | 3 |
| ADAMTS16 | FMNL3 | 0.622021 | 3 | 0 | 3 |
| ADAMTS16 | HIC1 | 0.618 | 4 | 0 | 4 |
| ADAMTS16 | ISLR | 0.617826 | 3 | 0 | 3 |
| ADAMTS16 | WDR86 | 0.617472 | 4 | 0 | 3 |
| ADAMTS16 | MTUS2 | 0.617281 | 3 | 0 | 3 |
| ADAMTS16 | IL10 | 0.613959 | 3 | 0 | 3 |
| ADAMTS16 | SORBS2 | 0.613039 | 3 | 0 | 3 |
| ADAMTS16 | TSPAN9 | 0.612918 | 3 | 0 | 3 |
| ADAMTS16 | GFPT2 | 0.612571 | 4 | 0 | 3 |
| ADAMTS16 | SCP2D1 | 0.606752 | 4 | 0 | 4 |
| ADAMTS16 | VASH1 | 0.601298 | 3 | 0 | 3 |
| ADAMTS16 | GPR26 | 0.60096 | 3 | 0 | 3 |
| ADAMTS16 | SNAI1 | 0.599955 | 5 | 0 | 3 |
| ADAMTS16 | TMEM204 | 0.599235 | 4 | 0 | 3 |
For details and further investigation, click here
