| Full name: interleukin 18 receptor 1 | Alias Symbol: IL1RRP|IL-1Rrp|CD218a | ||
| Type: protein-coding gene | Cytoband: 2q12.1 | ||
| Entrez ID: 8809 | HGNC ID: HGNC:5988 | Ensembl Gene: ENSG00000115604 | OMIM ID: 604494 |
| Drug and gene relationship at DGIdb | |||
IL18R1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05321 | Inflammatory bowel disease (IBD) |
Expression of IL18R1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL18R1 | 8809 | 206618_at | 0.1768 | 0.8670 | |
| GSE20347 | IL18R1 | 8809 | 206618_at | 0.1505 | 0.2030 | |
| GSE23400 | IL18R1 | 8809 | 206618_at | 0.0372 | 0.2547 | |
| GSE26886 | IL18R1 | 8809 | 206618_at | 0.5995 | 0.0263 | |
| GSE29001 | IL18R1 | 8809 | 206618_at | 0.3982 | 0.0698 | |
| GSE38129 | IL18R1 | 8809 | 206618_at | 0.0376 | 0.8067 | |
| GSE45670 | IL18R1 | 8809 | 206618_at | -0.8533 | 0.0075 | |
| GSE53622 | IL18R1 | 8809 | 78090 | 0.0478 | 0.7052 | |
| GSE53624 | IL18R1 | 8809 | 78090 | 0.0722 | 0.4425 | |
| GSE63941 | IL18R1 | 8809 | 206618_at | -0.2689 | 0.8216 | |
| GSE77861 | IL18R1 | 8809 | 206618_at | 0.1241 | 0.3872 | |
| GSE97050 | IL18R1 | 8809 | A_33_P3211666 | 0.4665 | 0.2787 | |
| SRP007169 | IL18R1 | 8809 | RNAseq | 0.2715 | 0.7566 | |
| SRP064894 | IL18R1 | 8809 | RNAseq | -0.2531 | 0.4579 | |
| SRP133303 | IL18R1 | 8809 | RNAseq | -0.5219 | 0.0238 | |
| SRP159526 | IL18R1 | 8809 | RNAseq | -0.1151 | 0.8401 | |
| SRP193095 | IL18R1 | 8809 | RNAseq | 0.0445 | 0.8582 | |
| SRP219564 | IL18R1 | 8809 | RNAseq | 0.3853 | 0.2968 | |
| TCGA | IL18R1 | 8809 | RNAseq | -0.3423 | 0.0622 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IL18R1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL18R1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL18R1 | 8809 | 5 | 2 | 23 | |
| GSE20123 | IL18R1 | 8809 | 5 | 2 | 23 | |
| GSE43470 | IL18R1 | 8809 | 4 | 1 | 38 | |
| GSE46452 | IL18R1 | 8809 | 1 | 4 | 54 | |
| GSE47630 | IL18R1 | 8809 | 7 | 0 | 33 | |
| GSE54993 | IL18R1 | 8809 | 0 | 6 | 64 | |
| GSE54994 | IL18R1 | 8809 | 11 | 0 | 42 | |
| GSE60625 | IL18R1 | 8809 | 0 | 3 | 8 | |
| GSE74703 | IL18R1 | 8809 | 4 | 1 | 31 | |
| GSE74704 | IL18R1 | 8809 | 3 | 1 | 16 | |
| TCGA | IL18R1 | 8809 | 35 | 5 | 56 |
Total number of gains: 75; Total number of losses: 25; Total Number of normals: 388.
Somatic mutations of IL18R1:
Generating mutation plots.
Highly correlated genes for IL18R1:
Showing top 20/74 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL18R1 | IGLL1 | 0.663704 | 3 | 0 | 3 |
| IL18R1 | ZC3H12D | 0.655245 | 4 | 0 | 3 |
| IL18R1 | RAB33A | 0.636231 | 3 | 0 | 3 |
| IL18R1 | C12orf76 | 0.630243 | 3 | 0 | 3 |
| IL18R1 | TNFSF13B | 0.623963 | 6 | 0 | 5 |
| IL18R1 | METTL7B | 0.620791 | 3 | 0 | 3 |
| IL18R1 | FGD5 | 0.613769 | 3 | 0 | 3 |
| IL18R1 | GIMAP2 | 0.613176 | 4 | 0 | 3 |
| IL18R1 | RCN1 | 0.60459 | 3 | 0 | 3 |
| IL18R1 | ISG20 | 0.60194 | 4 | 0 | 3 |
| IL18R1 | RNASE6 | 0.59137 | 5 | 0 | 3 |
| IL18R1 | GPSM3 | 0.589932 | 5 | 0 | 3 |
| IL18R1 | GPR171 | 0.586622 | 3 | 0 | 3 |
| IL18R1 | HEY1 | 0.580922 | 4 | 0 | 3 |
| IL18R1 | AKNA | 0.577465 | 6 | 0 | 4 |
| IL18R1 | APOL6 | 0.577304 | 4 | 0 | 3 |
| IL18R1 | FAM78A | 0.574864 | 4 | 0 | 3 |
| IL18R1 | AP3M2 | 0.57364 | 4 | 0 | 4 |
| IL18R1 | SASH3 | 0.572525 | 6 | 0 | 4 |
| IL18R1 | ETV5 | 0.570723 | 3 | 0 | 3 |
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