| Full name: interferon stimulated exonuclease gene 20 | Alias Symbol: HEM45|CD25 | ||
| Type: protein-coding gene | Cytoband: 15q26.1 | ||
| Entrez ID: 3669 | HGNC ID: HGNC:6130 | Ensembl Gene: ENSG00000172183 | OMIM ID: 604533 |
| Drug and gene relationship at DGIdb | |||
Expression of ISG20:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ISG20 | 3669 | 204698_at | -0.0248 | 0.9874 | |
| GSE20347 | ISG20 | 3669 | 204698_at | -0.7323 | 0.0261 | |
| GSE23400 | ISG20 | 3669 | 33304_at | -0.2567 | 0.0816 | |
| GSE26886 | ISG20 | 3669 | 33304_at | -0.0711 | 0.8325 | |
| GSE29001 | ISG20 | 3669 | 33304_at | -0.6472 | 0.1585 | |
| GSE38129 | ISG20 | 3669 | 204698_at | -0.4811 | 0.0983 | |
| GSE45670 | ISG20 | 3669 | 204698_at | -0.0735 | 0.8405 | |
| GSE53622 | ISG20 | 3669 | 123683 | -0.4525 | 0.0164 | |
| GSE53624 | ISG20 | 3669 | 123683 | -0.5888 | 0.0000 | |
| GSE63941 | ISG20 | 3669 | 204698_at | 1.4140 | 0.1820 | |
| GSE77861 | ISG20 | 3669 | 33304_at | -0.5025 | 0.0206 | |
| GSE97050 | ISG20 | 3669 | A_23_P32404 | 0.6891 | 0.3751 | |
| SRP007169 | ISG20 | 3669 | RNAseq | -1.9474 | 0.0001 | |
| SRP008496 | ISG20 | 3669 | RNAseq | -1.9129 | 0.0000 | |
| SRP064894 | ISG20 | 3669 | RNAseq | -0.0738 | 0.8266 | |
| SRP133303 | ISG20 | 3669 | RNAseq | 0.0118 | 0.9677 | |
| SRP159526 | ISG20 | 3669 | RNAseq | -0.9100 | 0.1495 | |
| SRP193095 | ISG20 | 3669 | RNAseq | -0.3908 | 0.1487 | |
| SRP219564 | ISG20 | 3669 | RNAseq | 0.3954 | 0.5597 | |
| TCGA | ISG20 | 3669 | RNAseq | -0.2315 | 0.1034 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by ISG20 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ISG20:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ISG20 | 3669 | 7 | 3 | 20 | |
| GSE20123 | ISG20 | 3669 | 7 | 3 | 20 | |
| GSE43470 | ISG20 | 3669 | 5 | 4 | 34 | |
| GSE46452 | ISG20 | 3669 | 3 | 7 | 49 | |
| GSE47630 | ISG20 | 3669 | 8 | 11 | 21 | |
| GSE54993 | ISG20 | 3669 | 4 | 6 | 60 | |
| GSE54994 | ISG20 | 3669 | 7 | 6 | 40 | |
| GSE60625 | ISG20 | 3669 | 4 | 0 | 7 | |
| GSE74703 | ISG20 | 3669 | 4 | 3 | 29 | |
| GSE74704 | ISG20 | 3669 | 4 | 2 | 14 | |
| TCGA | ISG20 | 3669 | 16 | 12 | 68 |
Total number of gains: 69; Total number of losses: 57; Total Number of normals: 362.
Somatic mutations of ISG20:
Generating mutation plots.
Highly correlated genes for ISG20:
Showing top 20/173 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ISG20 | SVOPL | 0.676801 | 3 | 0 | 3 |
| ISG20 | SPNS2 | 0.644798 | 3 | 0 | 3 |
| ISG20 | GPR174 | 0.640611 | 3 | 0 | 3 |
| ISG20 | MLKL | 0.632293 | 4 | 0 | 4 |
| ISG20 | CLECL1 | 0.629186 | 3 | 0 | 3 |
| ISG20 | CCDC120 | 0.627389 | 3 | 0 | 3 |
| ISG20 | IRF4 | 0.62285 | 5 | 0 | 4 |
| ISG20 | TRAT1 | 0.621572 | 7 | 0 | 4 |
| ISG20 | ICAM3 | 0.620838 | 7 | 0 | 5 |
| ISG20 | MACC1 | 0.619914 | 4 | 0 | 4 |
| ISG20 | FCRLA | 0.612805 | 4 | 0 | 3 |
| ISG20 | CLIC5 | 0.610885 | 3 | 0 | 3 |
| ISG20 | AP4B1 | 0.604942 | 4 | 0 | 4 |
| ISG20 | HSH2D | 0.603932 | 7 | 0 | 4 |
| ISG20 | TRAF3IP3 | 0.603444 | 6 | 0 | 3 |
| ISG20 | IL18R1 | 0.60194 | 4 | 0 | 3 |
| ISG20 | CHMP4C | 0.599747 | 3 | 0 | 3 |
| ISG20 | CD2 | 0.597249 | 9 | 0 | 8 |
| ISG20 | WAS | 0.591893 | 6 | 0 | 5 |
| ISG20 | CEACAM21 | 0.591861 | 5 | 0 | 4 |
For details and further investigation, click here
