| Full name: ribonuclease A family member k6 | Alias Symbol: RAD1|RNaseK6 | ||
| Type: protein-coding gene | Cytoband: 14q11.2 | ||
| Entrez ID: 6039 | HGNC ID: HGNC:10048 | Ensembl Gene: ENSG00000169413 | OMIM ID: 601981 |
| Drug and gene relationship at DGIdb | |||
Expression of RNASE6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RNASE6 | 6039 | 213566_at | -0.1962 | 0.9088 | |
| GSE20347 | RNASE6 | 6039 | 213566_at | -0.3502 | 0.0141 | |
| GSE23400 | RNASE6 | 6039 | 213566_at | 0.1300 | 0.1594 | |
| GSE26886 | RNASE6 | 6039 | 213566_at | 0.0353 | 0.9323 | |
| GSE29001 | RNASE6 | 6039 | 213566_at | 0.3338 | 0.2855 | |
| GSE38129 | RNASE6 | 6039 | 213566_at | -0.2487 | 0.3866 | |
| GSE45670 | RNASE6 | 6039 | 213566_at | -0.8855 | 0.0205 | |
| GSE63941 | RNASE6 | 6039 | 213566_at | -0.0995 | 0.6632 | |
| GSE77861 | RNASE6 | 6039 | 213566_at | -0.0775 | 0.7223 | |
| GSE97050 | RNASE6 | 6039 | A_23_P3014 | 0.5448 | 0.2460 | |
| SRP007169 | RNASE6 | 6039 | RNAseq | 0.6995 | 0.2796 | |
| SRP008496 | RNASE6 | 6039 | RNAseq | 0.4143 | 0.3320 | |
| SRP064894 | RNASE6 | 6039 | RNAseq | 0.6758 | 0.0670 | |
| SRP133303 | RNASE6 | 6039 | RNAseq | 0.0753 | 0.8156 | |
| SRP159526 | RNASE6 | 6039 | RNAseq | -0.4529 | 0.6014 | |
| SRP193095 | RNASE6 | 6039 | RNAseq | -0.0609 | 0.8016 | |
| SRP219564 | RNASE6 | 6039 | RNAseq | 1.0862 | 0.0989 | |
| TCGA | RNASE6 | 6039 | RNAseq | 0.1435 | 0.3648 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RNASE6 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of RNASE6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RNASE6 | 6039 | 9 | 3 | 18 | |
| GSE20123 | RNASE6 | 6039 | 8 | 3 | 19 | |
| GSE43470 | RNASE6 | 6039 | 7 | 1 | 35 | |
| GSE46452 | RNASE6 | 6039 | 19 | 2 | 38 | |
| GSE47630 | RNASE6 | 6039 | 10 | 10 | 20 | |
| GSE54993 | RNASE6 | 6039 | 3 | 11 | 56 | |
| GSE54994 | RNASE6 | 6039 | 18 | 5 | 30 | |
| GSE60625 | RNASE6 | 6039 | 0 | 2 | 9 | |
| GSE74703 | RNASE6 | 6039 | 6 | 1 | 29 | |
| GSE74704 | RNASE6 | 6039 | 4 | 2 | 14 | |
| TCGA | RNASE6 | 6039 | 27 | 16 | 53 |
Total number of gains: 111; Total number of losses: 56; Total Number of normals: 321.
Somatic mutations of RNASE6:
Generating mutation plots.
Highly correlated genes for RNASE6:
Showing top 20/318 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RNASE6 | MPEG1 | 0.803659 | 4 | 0 | 4 |
| RNASE6 | CYTIP | 0.747173 | 8 | 0 | 7 |
| RNASE6 | FAM78A | 0.745528 | 3 | 0 | 3 |
| RNASE6 | CYBB | 0.728549 | 9 | 0 | 9 |
| RNASE6 | CD53 | 0.724299 | 10 | 0 | 9 |
| RNASE6 | EVI2A | 0.724035 | 10 | 0 | 9 |
| RNASE6 | HCST | 0.722694 | 6 | 0 | 6 |
| RNASE6 | IL10RA | 0.72249 | 9 | 0 | 9 |
| RNASE6 | TNFSF13B | 0.713777 | 5 | 0 | 5 |
| RNASE6 | COTL1 | 0.702617 | 3 | 0 | 3 |
| RNASE6 | AIF1 | 0.701872 | 10 | 0 | 9 |
| RNASE6 | MS4A6A | 0.69989 | 9 | 0 | 7 |
| RNASE6 | EVI2B | 0.698094 | 10 | 0 | 8 |
| RNASE6 | MS4A7 | 0.695576 | 4 | 0 | 4 |
| RNASE6 | C16orf54 | 0.693232 | 4 | 0 | 3 |
| RNASE6 | CD1D | 0.692082 | 6 | 0 | 5 |
| RNASE6 | GMFG | 0.690644 | 10 | 0 | 8 |
| RNASE6 | DOCK2 | 0.685986 | 10 | 0 | 8 |
| RNASE6 | IRF8 | 0.684624 | 9 | 0 | 7 |
| RNASE6 | PLA2G7 | 0.68195 | 5 | 0 | 5 |
For details and further investigation, click here
