ZWILCH

 

Full name: zwilch kinetochore protein Alias Symbol: FLJ10036|KNTC1AP
Type: protein-coding gene Cytoband: 15q22.31
Entrez ID: 55055 HGNC ID: HGNC:25468 Ensembl Gene: ENSG00000174442 OMIM ID: 609984
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of ZWILCH:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ZWILCH 55055 222606_at 0.6670 0.3636
GSE20347 ZWILCH 55055 218349_s_at 1.0430 0.0001
GSE23400 ZWILCH 55055 218349_s_at 0.8826 0.0000
GSE26886 ZWILCH 55055 222606_at 0.1087 0.6772
GSE29001 ZWILCH 55055 218349_s_at 0.6231 0.1566
GSE38129 ZWILCH 55055 218349_s_at 1.3169 0.0003
GSE45670 ZWILCH 55055 222606_at 0.7762 0.0002
GSE53622 ZWILCH 55055 54306 1.1101 0.0000
GSE53624 ZWILCH 55055 73751 0.9591 0.0000
GSE63941 ZWILCH 55055 222606_at 1.3026 0.0027
GSE77861 ZWILCH 55055 222606_at 0.8451 0.0318
GSE97050 ZWILCH 55055 A_33_P3433873 0.6879 0.1708
SRP007169 ZWILCH 55055 RNAseq 0.6646 0.1057
SRP008496 ZWILCH 55055 RNAseq 0.6965 0.0137
SRP064894 ZWILCH 55055 RNAseq 0.6625 0.0048
SRP133303 ZWILCH 55055 RNAseq 1.1820 0.0000
SRP159526 ZWILCH 55055 RNAseq 0.5644 0.1236
SRP193095 ZWILCH 55055 RNAseq 0.5439 0.0000
SRP219564 ZWILCH 55055 RNAseq 0.5493 0.2788
TCGA ZWILCH 55055 RNAseq 0.5294 0.0000

Upregulated datasets: 5; Downregulated datasets: 0.  

 

Survival by ZWILCH expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ZWILCH:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ZWILCH 55055 7 3 20
GSE20123 ZWILCH 55055 7 3 20
GSE43470 ZWILCH 55055 4 6 33
GSE46452 ZWILCH 55055 3 7 49
GSE47630 ZWILCH 55055 8 10 22
GSE54993 ZWILCH 55055 5 6 59
GSE54994 ZWILCH 55055 6 7 40
GSE60625 ZWILCH 55055 4 0 7
GSE74703 ZWILCH 55055 4 3 29
GSE74704 ZWILCH 55055 3 3 14
TCGA ZWILCH 55055 9 16 71

Total number of gains: 60; Total number of losses: 64; Total Number of normals: 364.  

 

Somatic mutations of ZWILCH:

 

Generating mutation plots.

 

Highly correlated genes for ZWILCH:

 

Showing top 20/1560 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ZWILCHKNSTRN0.8342606
ZWILCHCENPW0.819697707
ZWILCHCCNB20.81118312012
ZWILCHKIF230.78528813013
ZWILCHCDK10.77787312012
ZWILCHPRC10.77474513013
ZWILCHNUSAP10.76923713013
ZWILCHCCNA20.76267712012
ZWILCHTTK0.76136913012
ZWILCHBUB1B0.753011009
ZWILCHCEP550.75231913012
ZWILCHMKI670.75229312012
ZWILCHESCO20.751336707
ZWILCHUBE2T0.748818807
ZWILCHMMS22L0.744486303
ZWILCHGINS10.74355212012
ZWILCHKIF110.74349813013
ZWILCHBIRC50.74078712011
ZWILCHOIP50.7392810010
ZWILCHDDIAS0.739101706

For details and further investigation, click here