| Full name: complement factor I | Alias Symbol: FI|C3b-INA|KAF | ||
| Type: protein-coding gene | Cytoband: 4q25 | ||
| Entrez ID: 3426 | HGNC ID: HGNC:5394 | Ensembl Gene: ENSG00000205403 | OMIM ID: 217030 |
| Drug and gene relationship at DGIdb | |||
CFI involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05150 | Staphylococcus aureus infection |
Expression of CFI:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CFI | 3426 | 203854_at | -0.2046 | 0.8807 | |
| GSE20347 | CFI | 3426 | 203854_at | -0.5225 | 0.1109 | |
| GSE23400 | CFI | 3426 | 203854_at | 0.0995 | 0.3186 | |
| GSE26886 | CFI | 3426 | 203854_at | -0.9293 | 0.2412 | |
| GSE29001 | CFI | 3426 | 203854_at | -0.5255 | 0.2783 | |
| GSE38129 | CFI | 3426 | 203854_at | -0.1651 | 0.6398 | |
| GSE45670 | CFI | 3426 | 203854_at | 0.0247 | 0.9680 | |
| GSE53622 | CFI | 3426 | 3012 | -0.1295 | 0.4155 | |
| GSE53624 | CFI | 3426 | 3012 | -0.4016 | 0.0113 | |
| GSE63941 | CFI | 3426 | 203854_at | 0.6505 | 0.7469 | |
| GSE77861 | CFI | 3426 | 203854_at | -0.5150 | 0.2215 | |
| GSE97050 | CFI | 3426 | A_24_P92472 | 0.9055 | 0.1623 | |
| SRP007169 | CFI | 3426 | RNAseq | 0.4560 | 0.4058 | |
| SRP008496 | CFI | 3426 | RNAseq | 0.8508 | 0.0837 | |
| SRP064894 | CFI | 3426 | RNAseq | 1.1580 | 0.0000 | |
| SRP133303 | CFI | 3426 | RNAseq | 0.0269 | 0.9323 | |
| SRP159526 | CFI | 3426 | RNAseq | -0.5333 | 0.2066 | |
| SRP193095 | CFI | 3426 | RNAseq | -0.0728 | 0.8502 | |
| SRP219564 | CFI | 3426 | RNAseq | 0.5207 | 0.3988 | |
| TCGA | CFI | 3426 | RNAseq | -0.0510 | 0.7587 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CFI expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CFI:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CFI | 3426 | 1 | 12 | 17 | |
| GSE20123 | CFI | 3426 | 1 | 12 | 17 | |
| GSE43470 | CFI | 3426 | 0 | 13 | 30 | |
| GSE46452 | CFI | 3426 | 1 | 36 | 22 | |
| GSE47630 | CFI | 3426 | 0 | 20 | 20 | |
| GSE54993 | CFI | 3426 | 9 | 0 | 61 | |
| GSE54994 | CFI | 3426 | 1 | 10 | 42 | |
| GSE60625 | CFI | 3426 | 0 | 3 | 8 | |
| GSE74703 | CFI | 3426 | 0 | 11 | 25 | |
| GSE74704 | CFI | 3426 | 0 | 6 | 14 | |
| TCGA | CFI | 3426 | 8 | 35 | 53 |
Total number of gains: 21; Total number of losses: 158; Total Number of normals: 309.
Somatic mutations of CFI:
Generating mutation plots.
Highly correlated genes for CFI:
Showing top 20/196 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CFI | TK2 | 0.694103 | 3 | 0 | 3 |
| CFI | SUSD1 | 0.690931 | 3 | 0 | 3 |
| CFI | CFHR3 | 0.678296 | 4 | 0 | 3 |
| CFI | GPC6 | 0.674124 | 3 | 0 | 3 |
| CFI | SOX7 | 0.673723 | 3 | 0 | 3 |
| CFI | DSE | 0.667139 | 4 | 0 | 3 |
| CFI | IL1RAP | 0.664151 | 3 | 0 | 3 |
| CFI | GPR34 | 0.656103 | 4 | 0 | 3 |
| CFI | MYO3B | 0.655294 | 3 | 0 | 3 |
| CFI | ARHGAP31 | 0.654031 | 3 | 0 | 3 |
| CFI | LYSMD2 | 0.644609 | 3 | 0 | 3 |
| CFI | CCDC80 | 0.644494 | 3 | 0 | 3 |
| CFI | RUFY2 | 0.6368 | 3 | 0 | 3 |
| CFI | FMO1 | 0.636035 | 4 | 0 | 4 |
| CFI | FAS | 0.634337 | 4 | 0 | 3 |
| CFI | ZNF70 | 0.632852 | 3 | 0 | 3 |
| CFI | ROBO4 | 0.632481 | 3 | 0 | 3 |
| CFI | SLC15A2 | 0.630474 | 3 | 0 | 3 |
| CFI | PTPRE | 0.628768 | 4 | 0 | 3 |
| CFI | PLEKHA2 | 0.628721 | 4 | 0 | 3 |
For details and further investigation, click here
