| Full name: sperm associated antigen 1 | Alias Symbol: SP75|FLJ32920|HSD-3.8|TPIS|CT140|CILD28 | ||
| Type: protein-coding gene | Cytoband: 8q22.2 | ||
| Entrez ID: 6674 | HGNC ID: HGNC:11212 | Ensembl Gene: ENSG00000104450 | OMIM ID: 603395 |
| Drug and gene relationship at DGIdb | |||
Expression of SPAG1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPAG1 | 6674 | 210117_at | 0.0405 | 0.9779 | |
| GSE20347 | SPAG1 | 6674 | 210117_at | -1.5040 | 0.0000 | |
| GSE23400 | SPAG1 | 6674 | 210117_at | -0.7128 | 0.0000 | |
| GSE26886 | SPAG1 | 6674 | 210117_at | -2.1708 | 0.0000 | |
| GSE29001 | SPAG1 | 6674 | 210117_at | -0.8027 | 0.1810 | |
| GSE38129 | SPAG1 | 6674 | 210117_at | -1.0104 | 0.0023 | |
| GSE45670 | SPAG1 | 6674 | 210117_at | -0.8227 | 0.0053 | |
| GSE53622 | SPAG1 | 6674 | 53128 | -0.3878 | 0.0092 | |
| GSE53624 | SPAG1 | 6674 | 53128 | -1.1438 | 0.0000 | |
| GSE63941 | SPAG1 | 6674 | 210117_at | 0.8287 | 0.1679 | |
| GSE77861 | SPAG1 | 6674 | 210117_at | -1.4122 | 0.0304 | |
| GSE97050 | SPAG1 | 6674 | A_23_P146066 | 0.3486 | 0.5837 | |
| SRP007169 | SPAG1 | 6674 | RNAseq | -2.7727 | 0.0000 | |
| SRP008496 | SPAG1 | 6674 | RNAseq | -2.3273 | 0.0000 | |
| SRP064894 | SPAG1 | 6674 | RNAseq | -1.7477 | 0.0000 | |
| SRP133303 | SPAG1 | 6674 | RNAseq | -0.8368 | 0.0042 | |
| SRP159526 | SPAG1 | 6674 | RNAseq | -0.9754 | 0.0242 | |
| SRP193095 | SPAG1 | 6674 | RNAseq | -1.2050 | 0.0000 | |
| SRP219564 | SPAG1 | 6674 | RNAseq | -1.4072 | 0.0267 | |
| TCGA | SPAG1 | 6674 | RNAseq | -0.0019 | 0.9836 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by SPAG1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPAG1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPAG1 | 6674 | 17 | 0 | 13 | |
| GSE20123 | SPAG1 | 6674 | 17 | 0 | 13 | |
| GSE43470 | SPAG1 | 6674 | 21 | 0 | 22 | |
| GSE46452 | SPAG1 | 6674 | 24 | 0 | 35 | |
| GSE47630 | SPAG1 | 6674 | 24 | 0 | 16 | |
| GSE54993 | SPAG1 | 6674 | 0 | 20 | 50 | |
| GSE54994 | SPAG1 | 6674 | 38 | 1 | 14 | |
| GSE60625 | SPAG1 | 6674 | 0 | 4 | 7 | |
| GSE74703 | SPAG1 | 6674 | 18 | 0 | 18 | |
| GSE74704 | SPAG1 | 6674 | 12 | 0 | 8 | |
| TCGA | SPAG1 | 6674 | 59 | 1 | 36 |
Total number of gains: 230; Total number of losses: 26; Total Number of normals: 232.
Somatic mutations of SPAG1:
Generating mutation plots.
Highly correlated genes for SPAG1:
Showing top 20/1164 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPAG1 | ASCC3 | 0.767844 | 3 | 0 | 3 |
| SPAG1 | ATP6V1C2 | 0.75054 | 4 | 0 | 4 |
| SPAG1 | SLC31A1 | 0.726765 | 3 | 0 | 3 |
| SPAG1 | RASAL2 | 0.71954 | 10 | 0 | 10 |
| SPAG1 | GOLGA4 | 0.718603 | 7 | 0 | 7 |
| SPAG1 | IL1RAP | 0.706867 | 4 | 0 | 3 |
| SPAG1 | RIPK3 | 0.705104 | 4 | 0 | 3 |
| SPAG1 | WWC1 | 0.704212 | 12 | 0 | 11 |
| SPAG1 | ARNTL2 | 0.698707 | 11 | 0 | 11 |
| SPAG1 | USP38 | 0.697629 | 3 | 0 | 3 |
| SPAG1 | EPG5 | 0.697367 | 4 | 0 | 3 |
| SPAG1 | IL18 | 0.696521 | 10 | 0 | 9 |
| SPAG1 | PHLDA1 | 0.69548 | 11 | 0 | 10 |
| SPAG1 | CCDC85C | 0.694633 | 3 | 0 | 3 |
| SPAG1 | TMEM139 | 0.694214 | 3 | 0 | 3 |
| SPAG1 | MPZL3 | 0.693287 | 8 | 0 | 8 |
| SPAG1 | YTHDF2 | 0.690933 | 3 | 0 | 3 |
| SPAG1 | ACTR3C | 0.690916 | 4 | 0 | 4 |
| SPAG1 | OXNAD1 | 0.690738 | 4 | 0 | 4 |
| SPAG1 | GTPBP2 | 0.686176 | 9 | 0 | 8 |
For details and further investigation, click here
