| Full name: interleukin 22 | Alias Symbol: ILTIF|IL-21|zcyto18|IL-TIF|IL-D110|TIFa|TIFIL-23|IL-22|MGC79382|MGC79384 | ||
| Type: protein-coding gene | Cytoband: 12q15 | ||
| Entrez ID: 50616 | HGNC ID: HGNC:14900 | Ensembl Gene: ENSG00000127318 | OMIM ID: 605330 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
IL22 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway | |
| hsa05321 | Inflammatory bowel disease (IBD) |
Expression of IL22:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL22 | 50616 | 221165_s_at | 0.0517 | 0.8842 | |
| GSE20347 | IL22 | 50616 | 221165_s_at | -0.0687 | 0.2855 | |
| GSE23400 | IL22 | 50616 | 221165_s_at | -0.1929 | 0.0000 | |
| GSE26886 | IL22 | 50616 | 221165_s_at | -0.0616 | 0.6533 | |
| GSE29001 | IL22 | 50616 | 221165_s_at | -0.2315 | 0.1367 | |
| GSE38129 | IL22 | 50616 | 221165_s_at | -0.1680 | 0.0097 | |
| GSE45670 | IL22 | 50616 | 221165_s_at | 0.0999 | 0.1831 | |
| GSE53622 | IL22 | 50616 | 12243 | -0.0791 | 0.6319 | |
| GSE53624 | IL22 | 50616 | 12243 | -0.1387 | 0.4733 | |
| GSE63941 | IL22 | 50616 | 221165_s_at | 0.1860 | 0.2610 | |
| GSE77861 | IL22 | 50616 | 221165_s_at | -0.0762 | 0.3633 | |
| TCGA | IL22 | 50616 | RNAseq | 2.2672 | 0.2040 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IL22 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL22:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL22 | 50616 | 6 | 0 | 24 | |
| GSE20123 | IL22 | 50616 | 6 | 0 | 24 | |
| GSE43470 | IL22 | 50616 | 5 | 0 | 38 | |
| GSE46452 | IL22 | 50616 | 13 | 0 | 46 | |
| GSE47630 | IL22 | 50616 | 10 | 1 | 29 | |
| GSE54993 | IL22 | 50616 | 0 | 8 | 62 | |
| GSE54994 | IL22 | 50616 | 7 | 1 | 45 | |
| GSE60625 | IL22 | 50616 | 0 | 0 | 11 | |
| GSE74703 | IL22 | 50616 | 5 | 0 | 31 | |
| GSE74704 | IL22 | 50616 | 5 | 0 | 15 | |
| TCGA | IL22 | 50616 | 24 | 9 | 63 |
Total number of gains: 81; Total number of losses: 19; Total Number of normals: 388.
Somatic mutations of IL22:
Generating mutation plots.
Highly correlated genes for IL22:
Showing top 20/519 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL22 | SLC17A3 | 0.707475 | 4 | 0 | 4 |
| IL22 | RHAG | 0.694372 | 4 | 0 | 4 |
| IL22 | HAAO | 0.683722 | 4 | 0 | 4 |
| IL22 | FUT9 | 0.682108 | 3 | 0 | 3 |
| IL22 | DNAI2 | 0.681496 | 3 | 0 | 3 |
| IL22 | CACNB4 | 0.676563 | 3 | 0 | 3 |
| IL22 | GPR31 | 0.674692 | 4 | 0 | 4 |
| IL22 | LUZP4 | 0.66527 | 3 | 0 | 3 |
| IL22 | CHRNA9 | 0.663876 | 3 | 0 | 3 |
| IL22 | KLK3 | 0.661805 | 4 | 0 | 4 |
| IL22 | MASP2 | 0.65957 | 6 | 0 | 5 |
| IL22 | SLC12A3 | 0.65835 | 4 | 0 | 4 |
| IL22 | SLC4A4 | 0.658285 | 4 | 0 | 3 |
| IL22 | NEU3 | 0.656476 | 3 | 0 | 3 |
| IL22 | ASCL3 | 0.655871 | 5 | 0 | 4 |
| IL22 | PRPH2 | 0.652656 | 4 | 0 | 3 |
| IL22 | EFR3B | 0.65247 | 4 | 0 | 4 |
| IL22 | MAGEA8 | 0.651609 | 4 | 0 | 3 |
| IL22 | PGK2 | 0.649084 | 4 | 0 | 3 |
| IL22 | SLC6A5 | 0.647673 | 4 | 0 | 4 |
For details and further investigation, click here
