| Full name: calcium voltage-gated channel auxiliary subunit beta 4 | Alias Symbol: EJM4 | ||
| Type: protein-coding gene | Cytoband: 2q23.3 | ||
| Entrez ID: 785 | HGNC ID: HGNC:1404 | Ensembl Gene: ENSG00000182389 | OMIM ID: 601949 |
| Drug and gene relationship at DGIdb | |||
CACNB4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04261 | Adrenergic signaling in cardiomyocytes | |
| hsa04921 | Oxytocin signaling pathway |
Expression of CACNB4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CACNB4 | 785 | 207693_at | -0.9392 | 0.1756 | |
| GSE20347 | CACNB4 | 785 | 207693_at | -0.2067 | 0.0433 | |
| GSE23400 | CACNB4 | 785 | 207693_at | -0.2453 | 0.0000 | |
| GSE26886 | CACNB4 | 785 | 207693_at | -0.1284 | 0.3034 | |
| GSE29001 | CACNB4 | 785 | 207693_at | -0.5366 | 0.0007 | |
| GSE38129 | CACNB4 | 785 | 207693_at | -0.3526 | 0.0047 | |
| GSE45670 | CACNB4 | 785 | 207693_at | -0.0553 | 0.6632 | |
| GSE53622 | CACNB4 | 785 | 129636 | -2.2113 | 0.0000 | |
| GSE53624 | CACNB4 | 785 | 129636 | -2.7080 | 0.0000 | |
| GSE63941 | CACNB4 | 785 | 207693_at | -0.8329 | 0.0000 | |
| GSE77861 | CACNB4 | 785 | 207693_at | -0.1093 | 0.5622 | |
| GSE97050 | CACNB4 | 785 | A_33_P3221989 | -0.5528 | 0.4324 | |
| SRP064894 | CACNB4 | 785 | RNAseq | -0.8909 | 0.0365 | |
| SRP133303 | CACNB4 | 785 | RNAseq | -1.7738 | 0.0000 | |
| SRP159526 | CACNB4 | 785 | RNAseq | -2.1420 | 0.0000 | |
| SRP193095 | CACNB4 | 785 | RNAseq | -1.6830 | 0.0000 | |
| SRP219564 | CACNB4 | 785 | RNAseq | -1.4560 | 0.0862 | |
| TCGA | CACNB4 | 785 | RNAseq | -0.8041 | 0.0175 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by CACNB4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CACNB4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CACNB4 | 785 | 3 | 2 | 25 | |
| GSE20123 | CACNB4 | 785 | 3 | 2 | 25 | |
| GSE43470 | CACNB4 | 785 | 3 | 1 | 39 | |
| GSE46452 | CACNB4 | 785 | 1 | 4 | 54 | |
| GSE47630 | CACNB4 | 785 | 5 | 3 | 32 | |
| GSE54993 | CACNB4 | 785 | 0 | 5 | 65 | |
| GSE54994 | CACNB4 | 785 | 11 | 2 | 40 | |
| GSE60625 | CACNB4 | 785 | 0 | 3 | 8 | |
| GSE74703 | CACNB4 | 785 | 2 | 1 | 33 | |
| GSE74704 | CACNB4 | 785 | 2 | 0 | 18 | |
| TCGA | CACNB4 | 785 | 22 | 8 | 66 |
Total number of gains: 52; Total number of losses: 31; Total Number of normals: 405.
Somatic mutations of CACNB4:
Generating mutation plots.
Highly correlated genes for CACNB4:
Showing top 20/948 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CACNB4 | ANGPTL6 | 0.807545 | 3 | 0 | 3 |
| CACNB4 | ZNF292 | 0.745479 | 3 | 0 | 3 |
| CACNB4 | CGNL1 | 0.720535 | 4 | 0 | 4 |
| CACNB4 | CA13 | 0.704655 | 3 | 0 | 3 |
| CACNB4 | ABCA8 | 0.702082 | 6 | 0 | 5 |
| CACNB4 | BOK | 0.698613 | 3 | 0 | 3 |
| CACNB4 | SMTNL2 | 0.69781 | 4 | 0 | 4 |
| CACNB4 | GABRR2 | 0.696214 | 4 | 0 | 4 |
| CACNB4 | NR3C2 | 0.693824 | 4 | 0 | 4 |
| CACNB4 | BMP3 | 0.692982 | 4 | 0 | 4 |
| CACNB4 | SAG | 0.690212 | 3 | 0 | 3 |
| CACNB4 | SYNM | 0.688431 | 3 | 0 | 3 |
| CACNB4 | C11orf96 | 0.687361 | 3 | 0 | 3 |
| CACNB4 | C4orf3 | 0.685347 | 4 | 0 | 4 |
| CACNB4 | IL22 | 0.676563 | 3 | 0 | 3 |
| CACNB4 | XKR4 | 0.675964 | 3 | 0 | 3 |
| CACNB4 | RPS23 | 0.673057 | 4 | 0 | 4 |
| CACNB4 | CD226 | 0.672821 | 3 | 0 | 3 |
| CACNB4 | IL1RL1 | 0.672452 | 4 | 0 | 3 |
| CACNB4 | LIFR | 0.671969 | 4 | 0 | 4 |
For details and further investigation, click here
