IL6ST

 

Full name: interleukin 6 signal transducer Alias Symbol: GP130|CD130
Type: protein-coding gene Cytoband: 5q11.2
Entrez ID: 3572 HGNC ID: HGNC:6021 Ensembl Gene: ENSG00000134352 OMIM ID: 600694
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 17/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

IL6ST involved pathways:

KEGG pathway Description View
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04630Jak-STAT signaling pathway

 

Expression of IL6ST:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IL6ST 3572 212195_at -0.7594 0.0502
GSE20347 IL6ST 3572 212195_at -0.9413 0.0002
GSE23400 IL6ST 3572 212195_at -0.6683 0.0000
GSE26886 IL6ST 3572 212195_at -0.5415 0.1170
GSE29001 IL6ST 3572 212195_at -0.6182 0.0952
GSE38129 IL6ST 3572 212195_at -0.9857 0.0001
GSE45670 IL6ST 3572 212195_at -0.8344 0.0000
GSE53622 IL6ST 3572 6475 -1.1289 0.0000
GSE53624 IL6ST 3572 54752 -1.0428 0.0000
GSE63941 IL6ST 3572 212195_at -3.8233 0.0002
GSE77861 IL6ST 3572 212195_at -0.8139 0.0614
GSE97050 IL6ST 3572 A_32_P45168 -0.7127 0.1126
SRP007169 IL6ST 3572 RNAseq -0.9366 0.0070
SRP008496 IL6ST 3572 RNAseq -0.8433 0.0000
SRP064894 IL6ST 3572 RNAseq -0.4987 0.1160
SRP133303 IL6ST 3572 RNAseq -0.5352 0.0289
SRP159526 IL6ST 3572 RNAseq -0.8179 0.0151
SRP193095 IL6ST 3572 RNAseq -0.5199 0.0028
SRP219564 IL6ST 3572 RNAseq -0.2658 0.6736
TCGA IL6ST 3572 RNAseq -0.4591 0.0000

Upregulated datasets: 0; Downregulated datasets: 3.  

 

Survival by IL6ST expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IL6ST:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IL6ST 3572 0 13 17
GSE20123 IL6ST 3572 0 13 17
GSE43470 IL6ST 3572 1 12 30
GSE46452 IL6ST 3572 1 27 31
GSE47630 IL6ST 3572 2 16 22
GSE54993 IL6ST 3572 8 1 61
GSE54994 IL6ST 3572 2 19 32
GSE60625 IL6ST 3572 0 0 11
GSE74703 IL6ST 3572 1 9 26
GSE74704 IL6ST 3572 0 6 14
TCGA IL6ST 3572 7 46 43

Total number of gains: 22; Total number of losses: 162; Total Number of normals: 304.  

 

Somatic mutations of IL6ST:

 

Generating mutation plots.

 

Highly correlated genes for IL6ST:

 

Showing top 20/1406 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IL6STMRVI10.827738606
IL6STCLEC3B0.816214303
IL6STC1QTNF70.815024505
IL6STNEGR10.814589606
IL6STCYP21A20.807726303
IL6STNEXN0.803883606
IL6STPLCXD30.802206404
IL6STMFAP40.801194808
IL6STASPA0.797366909
IL6STMIR100HG0.797286505
IL6STPLAC90.796978504
IL6STMAGI2-AS30.795856505
IL6STANGPTL10.795816606
IL6STSORCS10.790066505
IL6STC70.78244808
IL6STRBPMS20.781571505
IL6STSYNPO20.775531707
IL6STACTBL20.767629303
IL6STCADM30.766944404
IL6STLRRN4CL0.765659606

For details and further investigation, click here