| Full name: thymine DNA glycosylase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 12q23.3 | ||
| Entrez ID: 6996 | HGNC ID: HGNC:11700 | Ensembl Gene: ENSG00000139372 | OMIM ID: 601423 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TDG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TDG | 6996 | 203743_s_at | 0.7661 | 0.1490 | |
| GSE20347 | TDG | 6996 | 203743_s_at | 0.3955 | 0.0049 | |
| GSE23400 | TDG | 6996 | 203743_s_at | 0.7360 | 0.0000 | |
| GSE26886 | TDG | 6996 | 203743_s_at | 0.1669 | 0.3806 | |
| GSE29001 | TDG | 6996 | 203743_s_at | 0.4700 | 0.0123 | |
| GSE38129 | TDG | 6996 | 203743_s_at | 0.7230 | 0.0000 | |
| GSE45670 | TDG | 6996 | 203743_s_at | 0.5140 | 0.0000 | |
| GSE53622 | TDG | 6996 | 82964 | 0.3339 | 0.0000 | |
| GSE53624 | TDG | 6996 | 82964 | 0.4653 | 0.0000 | |
| GSE63941 | TDG | 6996 | 203743_s_at | 0.1699 | 0.7603 | |
| GSE77861 | TDG | 6996 | 203743_s_at | 0.5632 | 0.0118 | |
| GSE97050 | TDG | 6996 | A_23_P204579 | 0.1666 | 0.4703 | |
| SRP007169 | TDG | 6996 | RNAseq | 0.4840 | 0.1731 | |
| SRP008496 | TDG | 6996 | RNAseq | 0.7075 | 0.0030 | |
| SRP064894 | TDG | 6996 | RNAseq | 0.1620 | 0.4549 | |
| SRP133303 | TDG | 6996 | RNAseq | 0.5625 | 0.0027 | |
| SRP159526 | TDG | 6996 | RNAseq | 0.3253 | 0.1882 | |
| SRP193095 | TDG | 6996 | RNAseq | 0.0465 | 0.6078 | |
| SRP219564 | TDG | 6996 | RNAseq | 0.0489 | 0.8971 | |
| TCGA | TDG | 6996 | RNAseq | 0.2332 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TDG expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TDG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TDG | 6996 | 4 | 2 | 24 | |
| GSE20123 | TDG | 6996 | 4 | 2 | 24 | |
| GSE43470 | TDG | 6996 | 2 | 0 | 41 | |
| GSE46452 | TDG | 6996 | 9 | 1 | 49 | |
| GSE47630 | TDG | 6996 | 9 | 1 | 30 | |
| GSE54993 | TDG | 6996 | 0 | 5 | 65 | |
| GSE54994 | TDG | 6996 | 4 | 2 | 47 | |
| GSE60625 | TDG | 6996 | 0 | 0 | 11 | |
| GSE74703 | TDG | 6996 | 2 | 0 | 34 | |
| GSE74704 | TDG | 6996 | 1 | 2 | 17 | |
| TCGA | TDG | 6996 | 19 | 11 | 66 |
Total number of gains: 54; Total number of losses: 26; Total Number of normals: 408.
Somatic mutations of TDG:
Generating mutation plots.
Highly correlated genes for TDG:
Showing top 20/1495 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TDG | TMEM167A | 0.776202 | 3 | 0 | 3 |
| TDG | TP53RK | 0.760162 | 3 | 0 | 3 |
| TDG | LEMD2 | 0.76 | 3 | 0 | 3 |
| TDG | INTS1 | 0.743976 | 3 | 0 | 3 |
| TDG | HYLS1 | 0.742853 | 3 | 0 | 3 |
| TDG | ABCD4 | 0.7387 | 3 | 0 | 3 |
| TDG | FAM161A | 0.737658 | 3 | 0 | 3 |
| TDG | UBE2J2 | 0.734904 | 3 | 0 | 3 |
| TDG | NIN | 0.728786 | 3 | 0 | 3 |
| TDG | HGS | 0.727827 | 4 | 0 | 4 |
| TDG | CENPBD1 | 0.726435 | 3 | 0 | 3 |
| TDG | GOPC | 0.725188 | 3 | 0 | 3 |
| TDG | BRMS1L | 0.720829 | 3 | 0 | 3 |
| TDG | GCC1 | 0.716872 | 3 | 0 | 3 |
| TDG | ZC3HC1 | 0.716857 | 3 | 0 | 3 |
| TDG | ZBTB9 | 0.714921 | 4 | 0 | 3 |
| TDG | WDR4 | 0.713279 | 5 | 0 | 4 |
| TDG | SAMD1 | 0.713172 | 4 | 0 | 3 |
| TDG | TMEM63B | 0.712094 | 4 | 0 | 3 |
| TDG | FZD6 | 0.711287 | 7 | 0 | 7 |
For details and further investigation, click here
