| Full name: IQ motif and Sec7 domain 1 | Alias Symbol: KIAA0763|GEP100|BRAG2|ARF-GEP100 | ||
| Type: protein-coding gene | Cytoband: 3p25.2 | ||
| Entrez ID: 9922 | HGNC ID: HGNC:29112 | Ensembl Gene: ENSG00000144711 | OMIM ID: 610166 |
| Drug and gene relationship at DGIdb | |||
Expression of IQSEC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IQSEC1 | 9922 | 203906_at | 0.0051 | 0.9941 | |
| GSE20347 | IQSEC1 | 9922 | 203907_s_at | 0.0780 | 0.5063 | |
| GSE23400 | IQSEC1 | 9922 | 203906_at | -0.1344 | 0.0154 | |
| GSE26886 | IQSEC1 | 9922 | 203906_at | 0.2138 | 0.3454 | |
| GSE29001 | IQSEC1 | 9922 | 203906_at | -0.0516 | 0.8385 | |
| GSE38129 | IQSEC1 | 9922 | 203906_at | -0.3501 | 0.0934 | |
| GSE45670 | IQSEC1 | 9922 | 203907_s_at | -0.1155 | 0.5068 | |
| GSE53622 | IQSEC1 | 9922 | 20995 | -0.2278 | 0.0062 | |
| GSE53624 | IQSEC1 | 9922 | 20995 | 0.0172 | 0.8056 | |
| GSE63941 | IQSEC1 | 9922 | 203907_s_at | -0.4807 | 0.1993 | |
| GSE77861 | IQSEC1 | 9922 | 203906_at | 0.1933 | 0.2376 | |
| GSE97050 | IQSEC1 | 9922 | A_33_P3289820 | -0.2789 | 0.4210 | |
| SRP007169 | IQSEC1 | 9922 | RNAseq | 1.6044 | 0.0051 | |
| SRP008496 | IQSEC1 | 9922 | RNAseq | 1.5193 | 0.0033 | |
| SRP064894 | IQSEC1 | 9922 | RNAseq | 0.2570 | 0.2057 | |
| SRP133303 | IQSEC1 | 9922 | RNAseq | -0.0270 | 0.8546 | |
| SRP159526 | IQSEC1 | 9922 | RNAseq | -0.1137 | 0.6696 | |
| SRP193095 | IQSEC1 | 9922 | RNAseq | 0.5159 | 0.0026 | |
| SRP219564 | IQSEC1 | 9922 | RNAseq | -0.0728 | 0.8725 | |
| TCGA | IQSEC1 | 9922 | RNAseq | -0.2736 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by IQSEC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IQSEC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IQSEC1 | 9922 | 1 | 17 | 12 | |
| GSE20123 | IQSEC1 | 9922 | 1 | 18 | 11 | |
| GSE43470 | IQSEC1 | 9922 | 0 | 21 | 22 | |
| GSE46452 | IQSEC1 | 9922 | 2 | 17 | 40 | |
| GSE47630 | IQSEC1 | 9922 | 2 | 23 | 15 | |
| GSE54993 | IQSEC1 | 9922 | 6 | 1 | 63 | |
| GSE54994 | IQSEC1 | 9922 | 1 | 33 | 19 | |
| GSE60625 | IQSEC1 | 9922 | 5 | 0 | 6 | |
| GSE74703 | IQSEC1 | 9922 | 0 | 17 | 19 | |
| GSE74704 | IQSEC1 | 9922 | 1 | 10 | 9 | |
| TCGA | IQSEC1 | 9922 | 1 | 68 | 27 |
Total number of gains: 20; Total number of losses: 225; Total Number of normals: 243.
Somatic mutations of IQSEC1:
Generating mutation plots.
Highly correlated genes for IQSEC1:
Showing top 20/857 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IQSEC1 | TNFSF12 | 0.762814 | 3 | 0 | 3 |
| IQSEC1 | MYEF2 | 0.733739 | 3 | 0 | 3 |
| IQSEC1 | ZFP92 | 0.732063 | 3 | 0 | 3 |
| IQSEC1 | CBX7 | 0.724283 | 6 | 0 | 6 |
| IQSEC1 | TUBG2 | 0.722561 | 4 | 0 | 4 |
| IQSEC1 | ZEB1 | 0.719036 | 3 | 0 | 3 |
| IQSEC1 | EIF1B | 0.711043 | 3 | 0 | 3 |
| IQSEC1 | CD34 | 0.709316 | 7 | 0 | 7 |
| IQSEC1 | KCNN1 | 0.708733 | 3 | 0 | 3 |
| IQSEC1 | PI4KB | 0.699948 | 3 | 0 | 3 |
| IQSEC1 | FAM168B | 0.698983 | 3 | 0 | 3 |
| IQSEC1 | KCND3 | 0.696597 | 4 | 0 | 4 |
| IQSEC1 | ATP10A | 0.689296 | 6 | 0 | 6 |
| IQSEC1 | ILK | 0.688054 | 7 | 0 | 7 |
| IQSEC1 | RASGRP2 | 0.686314 | 4 | 0 | 3 |
| IQSEC1 | CACNA1H | 0.685511 | 3 | 0 | 3 |
| IQSEC1 | CCDC69 | 0.683767 | 6 | 0 | 6 |
| IQSEC1 | DAPK1 | 0.682818 | 6 | 0 | 4 |
| IQSEC1 | TLN1 | 0.68124 | 6 | 0 | 5 |
| IQSEC1 | SPOP | 0.679895 | 6 | 0 | 5 |
For details and further investigation, click here
