IRF2

 

Full name: interferon regulatory factor 2 Alias Symbol: 
Type: protein-coding gene Cytoband: 4q35.1
Entrez ID: 3660 HGNC ID: HGNC:6117 Ensembl Gene: ENSG00000168310 OMIM ID: 147576
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 10/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of IRF2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IRF2 3660 203275_at -0.0860 0.9082
GSE20347 IRF2 3660 203275_at -0.2217 0.0775
GSE23400 IRF2 3660 203275_at 0.0160 0.8676
GSE26886 IRF2 3660 203275_at -0.0315 0.9068
GSE29001 IRF2 3660 203275_at -0.0285 0.9216
GSE38129 IRF2 3660 203275_at -0.1317 0.2467
GSE45670 IRF2 3660 203275_at 0.0057 0.9788
GSE63941 IRF2 3660 203275_at 0.4689 0.3345
GSE77861 IRF2 3660 203275_at 0.2244 0.2499
GSE97050 IRF2 3660 A_23_P125082 0.0973 0.7285
SRP007169 IRF2 3660 RNAseq -0.0958 0.7705
SRP008496 IRF2 3660 RNAseq -0.0884 0.6934
SRP064894 IRF2 3660 RNAseq 0.0560 0.7319
SRP133303 IRF2 3660 RNAseq 0.1856 0.2838
SRP159526 IRF2 3660 RNAseq 0.2304 0.3747
SRP193095 IRF2 3660 RNAseq 0.0291 0.8210
SRP219564 IRF2 3660 RNAseq -0.0369 0.9097
TCGA IRF2 3660 RNAseq -0.0112 0.8179

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by IRF2 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of IRF2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IRF2 3660 3 12 15
GSE20123 IRF2 3660 3 12 15
GSE43470 IRF2 3660 1 12 30
GSE46452 IRF2 3660 1 36 22
GSE47630 IRF2 3660 0 22 18
GSE54993 IRF2 3660 10 0 60
GSE54994 IRF2 3660 2 12 39
GSE60625 IRF2 3660 0 0 11
GSE74703 IRF2 3660 1 9 26
GSE74704 IRF2 3660 1 5 14
TCGA IRF2 3660 11 32 53

Total number of gains: 33; Total number of losses: 152; Total Number of normals: 303.  

 

Somatic mutations of IRF2:

 

Generating mutation plots.

 

Highly correlated genes for IRF2:

 

Showing top 20/106 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IRF2ZBTB330.762982303
IRF2NCSTN0.761611303
IRF2ZKSCAN10.713519303
IRF2PIK3R30.702498303
IRF2NCOR10.700029303
IRF2RABGAP10.697713303
IRF2CYGB0.6944303
IRF2NHS0.690032303
IRF2ZMIZ10.686234303
IRF2GLCCI10.685884303
IRF2SYNRG0.67782504
IRF2CXCL160.674109403
IRF2ORAI30.674075303
IRF2CTDSP20.673159403
IRF2TSC22D40.670631303
IRF2FAM167B0.658245303
IRF2MGAT4A0.64843504
IRF2EIF4ENIF10.647788403
IRF2FMO40.642297403
IRF2SNX250.640103404

For details and further investigation, click here