| Full name: iron-sulfur cluster assembly 1 | Alias Symbol: MGC4276|ISA1|hIscA | ||
| Type: protein-coding gene | Cytoband: 9q21.33 | ||
| Entrez ID: 81689 | HGNC ID: HGNC:28660 | Ensembl Gene: ENSG00000135070 | OMIM ID: 611006 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ISCA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ISCA1 | 81689 | 209274_s_at | -0.2673 | 0.6260 | |
| GSE20347 | ISCA1 | 81689 | 209274_s_at | 0.2348 | 0.2920 | |
| GSE23400 | ISCA1 | 81689 | 209273_s_at | 0.4730 | 0.0000 | |
| GSE26886 | ISCA1 | 81689 | 209273_s_at | 1.1640 | 0.0000 | |
| GSE29001 | ISCA1 | 81689 | 209274_s_at | 0.6546 | 0.0403 | |
| GSE38129 | ISCA1 | 81689 | 209274_s_at | 0.1106 | 0.6389 | |
| GSE45670 | ISCA1 | 81689 | 209274_s_at | -0.2057 | 0.3062 | |
| GSE53622 | ISCA1 | 81689 | 81501 | 0.2342 | 0.0013 | |
| GSE53624 | ISCA1 | 81689 | 81501 | 0.5845 | 0.0000 | |
| GSE63941 | ISCA1 | 81689 | 209274_s_at | -0.3746 | 0.5125 | |
| GSE77861 | ISCA1 | 81689 | 209274_s_at | 0.8138 | 0.0085 | |
| GSE97050 | ISCA1 | 81689 | A_23_P216766 | -0.0681 | 0.7900 | |
| SRP007169 | ISCA1 | 81689 | RNAseq | 1.1002 | 0.0071 | |
| SRP008496 | ISCA1 | 81689 | RNAseq | 0.9800 | 0.0002 | |
| SRP064894 | ISCA1 | 81689 | RNAseq | 0.5302 | 0.0015 | |
| SRP133303 | ISCA1 | 81689 | RNAseq | 0.4416 | 0.0086 | |
| SRP159526 | ISCA1 | 81689 | RNAseq | 0.2927 | 0.1966 | |
| SRP193095 | ISCA1 | 81689 | RNAseq | 0.2191 | 0.1146 | |
| SRP219564 | ISCA1 | 81689 | RNAseq | -0.1460 | 0.7245 | |
| TCGA | ISCA1 | 81689 | RNAseq | -0.1065 | 0.0667 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by ISCA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ISCA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ISCA1 | 81689 | 5 | 10 | 15 | |
| GSE20123 | ISCA1 | 81689 | 5 | 10 | 15 | |
| GSE43470 | ISCA1 | 81689 | 6 | 3 | 34 | |
| GSE46452 | ISCA1 | 81689 | 6 | 14 | 39 | |
| GSE47630 | ISCA1 | 81689 | 1 | 18 | 21 | |
| GSE54993 | ISCA1 | 81689 | 4 | 2 | 64 | |
| GSE54994 | ISCA1 | 81689 | 6 | 11 | 36 | |
| GSE60625 | ISCA1 | 81689 | 0 | 0 | 11 | |
| GSE74703 | ISCA1 | 81689 | 5 | 3 | 28 | |
| GSE74704 | ISCA1 | 81689 | 3 | 7 | 10 | |
| TCGA | ISCA1 | 81689 | 20 | 27 | 49 |
Total number of gains: 61; Total number of losses: 105; Total Number of normals: 322.
Somatic mutations of ISCA1:
Generating mutation plots.
Highly correlated genes for ISCA1:
Showing top 20/1334 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ISCA1 | SMARCE1 | 0.879536 | 3 | 0 | 3 |
| ISCA1 | EPPK1 | 0.797265 | 3 | 0 | 3 |
| ISCA1 | NASP | 0.76369 | 3 | 0 | 3 |
| ISCA1 | TEAD2 | 0.760724 | 3 | 0 | 3 |
| ISCA1 | FGL2 | 0.75333 | 3 | 0 | 3 |
| ISCA1 | PCGF2 | 0.74071 | 3 | 0 | 3 |
| ISCA1 | FBLN5 | 0.738165 | 3 | 0 | 3 |
| ISCA1 | FGF7 | 0.737238 | 3 | 0 | 3 |
| ISCA1 | COA5 | 0.732188 | 3 | 0 | 3 |
| ISCA1 | RAD21 | 0.732094 | 4 | 0 | 4 |
| ISCA1 | PLEKHB1 | 0.723288 | 3 | 0 | 3 |
| ISCA1 | ADCY3 | 0.72038 | 4 | 0 | 4 |
| ISCA1 | TSNARE1 | 0.719728 | 3 | 0 | 3 |
| ISCA1 | LRRC58 | 0.718808 | 3 | 0 | 3 |
| ISCA1 | PNO1 | 0.713276 | 3 | 0 | 3 |
| ISCA1 | SLC41A1 | 0.712318 | 6 | 0 | 6 |
| ISCA1 | TCEAL3 | 0.712191 | 3 | 0 | 3 |
| ISCA1 | ATXN1L | 0.711875 | 4 | 0 | 4 |
| ISCA1 | NAP1L5 | 0.711681 | 3 | 0 | 3 |
| ISCA1 | CENPL | 0.708405 | 4 | 0 | 4 |
For details and further investigation, click here
