MTHFD1

 

Full name: methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 14q23.3
Entrez ID: 4522 HGNC ID: HGNC:7432 Ensembl Gene: ENSG00000100714 OMIM ID: 172460
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of MTHFD1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MTHFD1 4522 202309_at 0.6697 0.1312
GSE20347 MTHFD1 4522 202309_at 0.4225 0.0008
GSE23400 MTHFD1 4522 202309_at 0.8110 0.0000
GSE26886 MTHFD1 4522 202309_at 0.4054 0.0806
GSE29001 MTHFD1 4522 202309_at 0.5352 0.0406
GSE38129 MTHFD1 4522 202309_at 0.4671 0.0000
GSE45670 MTHFD1 4522 202309_at 0.3192 0.0852
GSE53622 MTHFD1 4522 46213 0.6660 0.0000
GSE53624 MTHFD1 4522 46213 0.7202 0.0000
GSE63941 MTHFD1 4522 202309_at 1.6266 0.0009
GSE77861 MTHFD1 4522 202309_at 0.3580 0.4440
GSE97050 MTHFD1 4522 A_23_P117494 0.7102 0.1399
SRP007169 MTHFD1 4522 RNAseq 1.3920 0.0039
SRP008496 MTHFD1 4522 RNAseq 1.2268 0.0002
SRP064894 MTHFD1 4522 RNAseq 0.7127 0.0005
SRP133303 MTHFD1 4522 RNAseq 0.4455 0.0058
SRP159526 MTHFD1 4522 RNAseq 0.4154 0.3161
SRP193095 MTHFD1 4522 RNAseq 0.3308 0.0034
SRP219564 MTHFD1 4522 RNAseq 0.8880 0.0358
TCGA MTHFD1 4522 RNAseq 0.2106 0.0000

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by MTHFD1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MTHFD1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MTHFD1 4522 7 3 20
GSE20123 MTHFD1 4522 7 3 20
GSE43470 MTHFD1 4522 8 2 33
GSE46452 MTHFD1 4522 16 3 40
GSE47630 MTHFD1 4522 11 9 20
GSE54993 MTHFD1 4522 3 9 58
GSE54994 MTHFD1 4522 18 5 30
GSE60625 MTHFD1 4522 0 2 9
GSE74703 MTHFD1 4522 7 2 27
GSE74704 MTHFD1 4522 3 2 15
TCGA MTHFD1 4522 32 14 50

Total number of gains: 112; Total number of losses: 54; Total Number of normals: 322.  

 

Somatic mutations of MTHFD1:

 

Generating mutation plots.

 

Highly correlated genes for MTHFD1:

 

Showing top 20/1621 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MTHFD1CCDC85C0.80604303
MTHFD1MYOF0.798917303
MTHFD1WIPI20.777664303
MTHFD1WDHD10.75220513012
MTHFD1CDKN30.75022513012
MTHFD1AHCY0.745573403
MTHFD1KTI120.738446303
MTHFD1DLGAP50.7381712011
MTHFD1TIMM90.73786513013
MTHFD1VRK10.73443213013
MTHFD1TDRD50.731841303
MTHFD1PPHLN10.727232404
MTHFD1TM2D20.722403404
MTHFD1LRRC580.716197403
MTHFD1ACYP10.7149712011
MTHFD1GLRX50.71480913011
MTHFD1ROMO10.71434403
MTHFD1GINS10.71414312011
MTHFD1KDF10.713509303
MTHFD1GSTO20.712882303

For details and further investigation, click here