EML4

 

Full name: EMAP like 4 Alias Symbol: ROPP120|ELP120
Type: protein-coding gene Cytoband: 2p21
Entrez ID: 27436 HGNC ID: HGNC:1316 Ensembl Gene: ENSG00000143924 OMIM ID: 607442
Drug and gene relationship at DGIdb

 

EML4 involved pathways:

KEGG pathway Description View
hsa05223Non-small cell lung cancer

 

Expression of EML4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 EML4 27436 223068_at 0.7700 0.0208
GSE20347 EML4 27436 220386_s_at 0.4731 0.0002
GSE23400 EML4 27436 220386_s_at 0.6366 0.0000
GSE26886 EML4 27436 223068_at 0.1689 0.5046
GSE29001 EML4 27436 220386_s_at 0.3708 0.0294
GSE38129 EML4 27436 220386_s_at 0.6151 0.0001
GSE45670 EML4 27436 223068_at 0.2734 0.0994
GSE53622 EML4 27436 63277 0.8316 0.0000
GSE53624 EML4 27436 63277 0.6365 0.0000
GSE63941 EML4 27436 223068_at 0.1729 0.7673
GSE77861 EML4 27436 223068_at 0.6632 0.0130
GSE97050 EML4 27436 A_24_P273413 1.0031 0.0631
SRP007169 EML4 27436 RNAseq 1.2136 0.0021
SRP008496 EML4 27436 RNAseq 1.1095 0.0000
SRP064894 EML4 27436 RNAseq 0.5099 0.0101
SRP133303 EML4 27436 RNAseq 0.7430 0.0001
SRP159526 EML4 27436 RNAseq 0.4754 0.0310
SRP193095 EML4 27436 RNAseq 0.2964 0.0088
SRP219564 EML4 27436 RNAseq 0.6787 0.0475
TCGA EML4 27436 RNAseq 0.0079 0.8577

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by EML4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of EML4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 EML4 27436 12 1 17
GSE20123 EML4 27436 11 1 18
GSE43470 EML4 27436 3 0 40
GSE46452 EML4 27436 1 4 54
GSE47630 EML4 27436 7 0 33
GSE54993 EML4 27436 0 5 65
GSE54994 EML4 27436 10 0 43
GSE60625 EML4 27436 0 3 8
GSE74703 EML4 27436 3 0 33
GSE74704 EML4 27436 10 1 9
TCGA EML4 27436 34 3 59

Total number of gains: 91; Total number of losses: 18; Total Number of normals: 379.  

 

Somatic mutations of EML4:

 

Generating mutation plots.

 

Highly correlated genes for EML4:

 

Showing top 20/1822 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
EML4ZBTB90.795608303
EML4GORAB0.773437606
EML4C12orf750.766759404
EML4UBE2T0.760784606
EML4SLC26A60.750132303
EML4SLC19A10.747257303
EML4TMEM1380.742211606
EML4PYCR20.732406303
EML4UHMK10.730411504
EML4TMEM63B0.726855303
EML4CDCA20.725858504
EML4DNMT10.72517111010
EML4TOPBP10.72428911011
EML4CEP550.72369510010
EML4TNFRSF90.722002303
EML4ZNF3430.717857303
EML4DDX39A0.717772909
EML4ZNF4690.717218404
EML4FANCB0.715264404
EML4DNAJB110.715019606

For details and further investigation, click here