| Full name: tryptophanyl tRNA synthetase 2, mitochondrial | Alias Symbol: mtTrpRS | ||
| Type: protein-coding gene | Cytoband: 1p12 | ||
| Entrez ID: 10352 | HGNC ID: HGNC:12730 | Ensembl Gene: ENSG00000116874 | OMIM ID: 604733 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of WARS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WARS2 | 10352 | 222734_at | -0.0982 | 0.8690 | |
| GSE20347 | WARS2 | 10352 | 218766_s_at | 0.0413 | 0.8117 | |
| GSE23400 | WARS2 | 10352 | 218766_s_at | 0.0625 | 0.2216 | |
| GSE26886 | WARS2 | 10352 | 222734_at | 0.1340 | 0.7392 | |
| GSE29001 | WARS2 | 10352 | 218766_s_at | 0.1144 | 0.6184 | |
| GSE38129 | WARS2 | 10352 | 218766_s_at | 0.2074 | 0.3275 | |
| GSE45670 | WARS2 | 10352 | 218766_s_at | -0.2382 | 0.2395 | |
| GSE53622 | WARS2 | 10352 | 6907 | -0.3788 | 0.0007 | |
| GSE53624 | WARS2 | 10352 | 6907 | 0.0313 | 0.7317 | |
| GSE63941 | WARS2 | 10352 | 222734_at | 0.4644 | 0.4522 | |
| GSE77861 | WARS2 | 10352 | 222734_at | -0.1499 | 0.7195 | |
| GSE97050 | WARS2 | 10352 | A_33_P3338417 | -0.2440 | 0.2798 | |
| SRP007169 | WARS2 | 10352 | RNAseq | -0.1456 | 0.7582 | |
| SRP008496 | WARS2 | 10352 | RNAseq | -0.1720 | 0.5754 | |
| SRP064894 | WARS2 | 10352 | RNAseq | 0.1417 | 0.3661 | |
| SRP133303 | WARS2 | 10352 | RNAseq | -0.1420 | 0.3961 | |
| SRP159526 | WARS2 | 10352 | RNAseq | -0.7618 | 0.0019 | |
| SRP193095 | WARS2 | 10352 | RNAseq | -0.4032 | 0.0000 | |
| SRP219564 | WARS2 | 10352 | RNAseq | 0.0994 | 0.7668 | |
| TCGA | WARS2 | 10352 | RNAseq | -0.0217 | 0.7331 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by WARS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WARS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WARS2 | 10352 | 3 | 5 | 22 | |
| GSE20123 | WARS2 | 10352 | 4 | 5 | 21 | |
| GSE43470 | WARS2 | 10352 | 1 | 3 | 39 | |
| GSE46452 | WARS2 | 10352 | 2 | 1 | 56 | |
| GSE47630 | WARS2 | 10352 | 10 | 4 | 26 | |
| GSE54993 | WARS2 | 10352 | 0 | 2 | 68 | |
| GSE54994 | WARS2 | 10352 | 12 | 1 | 40 | |
| GSE60625 | WARS2 | 10352 | 0 | 0 | 11 | |
| GSE74703 | WARS2 | 10352 | 1 | 3 | 32 | |
| GSE74704 | WARS2 | 10352 | 2 | 3 | 15 | |
| TCGA | WARS2 | 10352 | 17 | 26 | 53 |
Total number of gains: 52; Total number of losses: 53; Total Number of normals: 383.
Somatic mutations of WARS2:
Generating mutation plots.
Highly correlated genes for WARS2:
Showing top 20/97 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WARS2 | PEX11B | 0.777049 | 3 | 0 | 3 |
| WARS2 | MAP3K8 | 0.764048 | 3 | 0 | 3 |
| WARS2 | TSPAN3 | 0.75704 | 3 | 0 | 3 |
| WARS2 | ACAP2 | 0.736678 | 3 | 0 | 3 |
| WARS2 | BTAF1 | 0.734169 | 3 | 0 | 3 |
| WARS2 | AP3M1 | 0.723818 | 3 | 0 | 3 |
| WARS2 | BCL10 | 0.71669 | 3 | 0 | 3 |
| WARS2 | IST1 | 0.716398 | 3 | 0 | 3 |
| WARS2 | CLEC2B | 0.707688 | 4 | 0 | 4 |
| WARS2 | ALDH5A1 | 0.706889 | 3 | 0 | 3 |
| WARS2 | RFX7 | 0.706649 | 3 | 0 | 3 |
| WARS2 | VPS52 | 0.705145 | 3 | 0 | 3 |
| WARS2 | SHMT2 | 0.704904 | 3 | 0 | 3 |
| WARS2 | PLEKHA7 | 0.702475 | 3 | 0 | 3 |
| WARS2 | PRDX4 | 0.70073 | 3 | 0 | 3 |
| WARS2 | TBC1D22B | 0.689495 | 3 | 0 | 3 |
| WARS2 | RPP38 | 0.685597 | 4 | 0 | 3 |
| WARS2 | SRPK1 | 0.671856 | 4 | 0 | 3 |
| WARS2 | SIAE | 0.666242 | 4 | 0 | 3 |
| WARS2 | RCAN3 | 0.66496 | 3 | 0 | 3 |
For details and further investigation, click here
