| Full name: integrin subunit alpha 5 | Alias Symbol: CD49e | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 3678 | HGNC ID: HGNC:6141 | Ensembl Gene: ENSG00000161638 | OMIM ID: 135620 |
| Drug and gene relationship at DGIdb | |||
ITGA5 involved pathways:
Expression of ITGA5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ITGA5 | 3678 | 201389_at | -0.4920 | 0.5604 | |
| GSE20347 | ITGA5 | 3678 | 201389_at | 1.1183 | 0.0000 | |
| GSE23400 | ITGA5 | 3678 | 201389_at | 0.5048 | 0.0000 | |
| GSE26886 | ITGA5 | 3678 | 201389_at | 1.7023 | 0.0000 | |
| GSE29001 | ITGA5 | 3678 | 201389_at | 0.4662 | 0.0514 | |
| GSE38129 | ITGA5 | 3678 | 201389_at | 0.7404 | 0.0017 | |
| GSE45670 | ITGA5 | 3678 | 201389_at | -0.1255 | 0.7284 | |
| GSE53622 | ITGA5 | 3678 | 7639 | 0.0954 | 0.5045 | |
| GSE53624 | ITGA5 | 3678 | 34556 | 1.0982 | 0.0000 | |
| GSE63941 | ITGA5 | 3678 | 201389_at | -0.4247 | 0.5478 | |
| GSE77861 | ITGA5 | 3678 | 201389_at | 0.7953 | 0.0344 | |
| GSE97050 | ITGA5 | 3678 | A_23_P36562 | 0.7187 | 0.1956 | |
| SRP007169 | ITGA5 | 3678 | RNAseq | 3.7782 | 0.0000 | |
| SRP008496 | ITGA5 | 3678 | RNAseq | 3.8687 | 0.0000 | |
| SRP064894 | ITGA5 | 3678 | RNAseq | 0.4750 | 0.2207 | |
| SRP133303 | ITGA5 | 3678 | RNAseq | 1.3111 | 0.0005 | |
| SRP159526 | ITGA5 | 3678 | RNAseq | -0.1849 | 0.7329 | |
| SRP193095 | ITGA5 | 3678 | RNAseq | 3.4151 | 0.0000 | |
| SRP219564 | ITGA5 | 3678 | RNAseq | 0.2062 | 0.7633 | |
| TCGA | ITGA5 | 3678 | RNAseq | -0.0666 | 0.4726 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by ITGA5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ITGA5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ITGA5 | 3678 | 4 | 1 | 25 | |
| GSE20123 | ITGA5 | 3678 | 4 | 1 | 25 | |
| GSE43470 | ITGA5 | 3678 | 3 | 0 | 40 | |
| GSE46452 | ITGA5 | 3678 | 7 | 1 | 51 | |
| GSE47630 | ITGA5 | 3678 | 10 | 2 | 28 | |
| GSE54993 | ITGA5 | 3678 | 0 | 5 | 65 | |
| GSE54994 | ITGA5 | 3678 | 4 | 1 | 48 | |
| GSE60625 | ITGA5 | 3678 | 0 | 0 | 11 | |
| GSE74703 | ITGA5 | 3678 | 3 | 0 | 33 | |
| GSE74704 | ITGA5 | 3678 | 3 | 1 | 16 | |
| TCGA | ITGA5 | 3678 | 16 | 11 | 69 |
Total number of gains: 54; Total number of losses: 23; Total Number of normals: 411.
Somatic mutations of ITGA5:
Generating mutation plots.
Highly correlated genes for ITGA5:
Showing top 20/956 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ITGA5 | RAVER1 | 0.732962 | 3 | 0 | 3 |
| ITGA5 | LIX1L | 0.730027 | 4 | 0 | 4 |
| ITGA5 | CYSTM1 | 0.727655 | 3 | 0 | 3 |
| ITGA5 | FAM126A | 0.727048 | 3 | 0 | 3 |
| ITGA5 | PLIN4 | 0.711572 | 3 | 0 | 3 |
| ITGA5 | IFT43 | 0.710795 | 3 | 0 | 3 |
| ITGA5 | STK38L | 0.709368 | 3 | 0 | 3 |
| ITGA5 | MICAL2 | 0.706738 | 9 | 0 | 9 |
| ITGA5 | KCTD13 | 0.703947 | 3 | 0 | 3 |
| ITGA5 | LOXL2 | 0.696556 | 11 | 0 | 9 |
| ITGA5 | EMP3 | 0.694323 | 12 | 0 | 11 |
| ITGA5 | NEK3 | 0.693393 | 3 | 0 | 3 |
| ITGA5 | INHBA | 0.690507 | 11 | 0 | 10 |
| ITGA5 | EID2B | 0.68588 | 4 | 0 | 3 |
| ITGA5 | FMNL2 | 0.685344 | 5 | 0 | 4 |
| ITGA5 | AGT | 0.6852 | 4 | 0 | 4 |
| ITGA5 | ACSS3 | 0.684899 | 3 | 0 | 3 |
| ITGA5 | COL5A1 | 0.682649 | 10 | 0 | 9 |
| ITGA5 | ARSI | 0.681121 | 4 | 0 | 4 |
| ITGA5 | TP53I13 | 0.68071 | 4 | 0 | 4 |
For details and further investigation, click here
