| Full name: potassium calcium-activated channel subfamily M regulatory beta subunit 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3q26.32 | ||
| Entrez ID: 27094 | HGNC ID: HGNC:6287 | Ensembl Gene: ENSG00000171121 | OMIM ID: 605222 |
| Drug and gene relationship at DGIdb | |||
KCNMB3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04022 | cGMP-PKG signaling pathway | |
| hsa04270 | Vascular smooth muscle contraction |
Expression of KCNMB3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KCNMB3 | 27094 | 221125_s_at | 0.3639 | 0.5207 | |
| GSE20347 | KCNMB3 | 27094 | 221125_s_at | 0.5797 | 0.0000 | |
| GSE23400 | KCNMB3 | 27094 | 221125_s_at | 0.1202 | 0.0037 | |
| GSE26886 | KCNMB3 | 27094 | 221125_s_at | 0.9548 | 0.0034 | |
| GSE29001 | KCNMB3 | 27094 | 221125_s_at | 0.7499 | 0.0001 | |
| GSE38129 | KCNMB3 | 27094 | 221125_s_at | 0.5726 | 0.0000 | |
| GSE45670 | KCNMB3 | 27094 | 221125_s_at | 0.4102 | 0.1080 | |
| GSE53622 | KCNMB3 | 27094 | 46919 | 1.1263 | 0.0000 | |
| GSE53624 | KCNMB3 | 27094 | 46919 | 1.3211 | 0.0000 | |
| GSE63941 | KCNMB3 | 27094 | 221125_s_at | 0.7556 | 0.0534 | |
| GSE77861 | KCNMB3 | 27094 | 221125_s_at | 0.2811 | 0.0543 | |
| GSE97050 | KCNMB3 | A_21_P0012333 | -0.3234 | 0.2717 | ||
| SRP064894 | KCNMB3 | 27094 | RNAseq | 1.2680 | 0.0000 | |
| SRP133303 | KCNMB3 | 27094 | RNAseq | 1.2685 | 0.0000 | |
| SRP159526 | KCNMB3 | 27094 | RNAseq | 2.0122 | 0.0000 | |
| SRP193095 | KCNMB3 | 27094 | RNAseq | 1.6691 | 0.0000 | |
| SRP219564 | KCNMB3 | 27094 | RNAseq | 1.6352 | 0.0004 | |
| TCGA | KCNMB3 | 27094 | RNAseq | 0.2351 | 0.0965 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by KCNMB3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KCNMB3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KCNMB3 | 27094 | 25 | 0 | 5 | |
| GSE20123 | KCNMB3 | 27094 | 25 | 0 | 5 | |
| GSE43470 | KCNMB3 | 27094 | 24 | 0 | 19 | |
| GSE46452 | KCNMB3 | 27094 | 19 | 1 | 39 | |
| GSE47630 | KCNMB3 | 27094 | 27 | 2 | 11 | |
| GSE54993 | KCNMB3 | 27094 | 1 | 18 | 51 | |
| GSE54994 | KCNMB3 | 27094 | 41 | 0 | 12 | |
| GSE60625 | KCNMB3 | 27094 | 0 | 6 | 5 | |
| GSE74703 | KCNMB3 | 27094 | 20 | 0 | 16 | |
| GSE74704 | KCNMB3 | 27094 | 16 | 0 | 4 | |
| TCGA | KCNMB3 | 27094 | 78 | 0 | 18 |
Total number of gains: 276; Total number of losses: 27; Total Number of normals: 185.
Somatic mutations of KCNMB3:
Generating mutation plots.
Highly correlated genes for KCNMB3:
Showing top 20/391 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KCNMB3 | PXYLP1 | 0.674716 | 6 | 0 | 6 |
| KCNMB3 | NCR3LG1 | 0.669178 | 3 | 0 | 3 |
| KCNMB3 | FAM168A | 0.661908 | 4 | 0 | 3 |
| KCNMB3 | STAT5B | 0.657159 | 3 | 0 | 3 |
| KCNMB3 | PLEKHH2 | 0.64343 | 3 | 0 | 3 |
| KCNMB3 | CHKA | 0.636146 | 4 | 0 | 3 |
| KCNMB3 | FAM227B | 0.633325 | 3 | 0 | 3 |
| KCNMB3 | AMIGO1 | 0.63024 | 3 | 0 | 3 |
| KCNMB3 | TMEM216 | 0.625473 | 4 | 0 | 3 |
| KCNMB3 | RPS19BP1 | 0.622447 | 3 | 0 | 3 |
| KCNMB3 | LRRC47 | 0.61839 | 3 | 0 | 3 |
| KCNMB3 | HEY1 | 0.614427 | 11 | 0 | 9 |
| KCNMB3 | LINC01139 | 0.613653 | 3 | 0 | 3 |
| KCNMB3 | WHAMM | 0.610892 | 3 | 0 | 3 |
| KCNMB3 | GNGT1 | 0.610662 | 6 | 0 | 5 |
| KCNMB3 | CRTC3 | 0.609973 | 5 | 0 | 5 |
| KCNMB3 | EIF2AK2 | 0.607756 | 8 | 0 | 7 |
| KCNMB3 | ASXL1 | 0.604118 | 5 | 0 | 3 |
| KCNMB3 | GOLM1 | 0.603213 | 5 | 0 | 5 |
| KCNMB3 | ACTL6A | 0.602749 | 12 | 0 | 10 |
For details and further investigation, click here
