| Full name: eukaryotic translation initiation factor 2 alpha kinase 2 | Alias Symbol: PKR|EIF2AK1|PPP1R83 | ||
| Type: protein-coding gene | Cytoband: 2p22.2 | ||
| Entrez ID: 5610 | HGNC ID: HGNC:9437 | Ensembl Gene: ENSG00000055332 | OMIM ID: 176871 |
| Drug and gene relationship at DGIdb | |||
EIF2AK2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05160 | Hepatitis C | |
| hsa05162 | Measles | |
| hsa05164 | Influenza A | |
| hsa05168 | Herpes simplex infection |
Expression of EIF2AK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF2AK2 | 5610 | 213294_at | 0.6581 | 0.2743 | |
| GSE20347 | EIF2AK2 | 5610 | 204211_x_at | 1.0312 | 0.0000 | |
| GSE23400 | EIF2AK2 | 5610 | 213294_at | 0.9964 | 0.0000 | |
| GSE26886 | EIF2AK2 | 5610 | 213294_at | 1.2367 | 0.0001 | |
| GSE29001 | EIF2AK2 | 5610 | 213294_at | 1.3551 | 0.0000 | |
| GSE38129 | EIF2AK2 | 5610 | 213294_at | 0.8301 | 0.0000 | |
| GSE45670 | EIF2AK2 | 5610 | 213294_at | 0.9271 | 0.0015 | |
| GSE53622 | EIF2AK2 | 5610 | 93592 | 1.3100 | 0.0000 | |
| GSE53624 | EIF2AK2 | 5610 | 93592 | 1.4723 | 0.0000 | |
| GSE63941 | EIF2AK2 | 5610 | 204211_x_at | 0.5315 | 0.1445 | |
| GSE77861 | EIF2AK2 | 5610 | 213294_at | 1.0511 | 0.0222 | |
| GSE97050 | EIF2AK2 | 5610 | A_23_P142750 | 0.3426 | 0.1672 | |
| SRP007169 | EIF2AK2 | 5610 | RNAseq | 2.1283 | 0.0000 | |
| SRP008496 | EIF2AK2 | 5610 | RNAseq | 2.2964 | 0.0000 | |
| SRP064894 | EIF2AK2 | 5610 | RNAseq | 1.5056 | 0.0000 | |
| SRP133303 | EIF2AK2 | 5610 | RNAseq | 1.0676 | 0.0000 | |
| SRP159526 | EIF2AK2 | 5610 | RNAseq | 0.8391 | 0.0070 | |
| SRP193095 | EIF2AK2 | 5610 | RNAseq | 1.2811 | 0.0000 | |
| SRP219564 | EIF2AK2 | 5610 | RNAseq | 0.7582 | 0.1492 | |
| TCGA | EIF2AK2 | 5610 | RNAseq | 0.3926 | 0.0000 |
Upregulated datasets: 11; Downregulated datasets: 0.
Survival by EIF2AK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EIF2AK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF2AK2 | 5610 | 10 | 1 | 19 | |
| GSE20123 | EIF2AK2 | 5610 | 9 | 1 | 20 | |
| GSE43470 | EIF2AK2 | 5610 | 3 | 0 | 40 | |
| GSE46452 | EIF2AK2 | 5610 | 1 | 4 | 54 | |
| GSE47630 | EIF2AK2 | 5610 | 7 | 0 | 33 | |
| GSE54993 | EIF2AK2 | 5610 | 0 | 5 | 65 | |
| GSE54994 | EIF2AK2 | 5610 | 10 | 0 | 43 | |
| GSE60625 | EIF2AK2 | 5610 | 0 | 3 | 8 | |
| GSE74703 | EIF2AK2 | 5610 | 3 | 0 | 33 | |
| GSE74704 | EIF2AK2 | 5610 | 9 | 1 | 10 | |
| TCGA | EIF2AK2 | 5610 | 35 | 2 | 59 |
Total number of gains: 87; Total number of losses: 17; Total Number of normals: 384.
Somatic mutations of EIF2AK2:
Generating mutation plots.
Highly correlated genes for EIF2AK2:
Showing top 20/1595 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF2AK2 | USP41 | 0.83491 | 3 | 0 | 3 |
| EIF2AK2 | FCGR3A | 0.758081 | 3 | 0 | 3 |
| EIF2AK2 | CMPK2 | 0.75339 | 7 | 0 | 7 |
| EIF2AK2 | GNG10 | 0.735842 | 3 | 0 | 3 |
| EIF2AK2 | ADAR | 0.733651 | 13 | 0 | 12 |
| EIF2AK2 | ZNFX1 | 0.726813 | 7 | 0 | 7 |
| EIF2AK2 | PTPRK | 0.724278 | 11 | 0 | 10 |
| EIF2AK2 | SSBP4 | 0.724042 | 3 | 0 | 3 |
| EIF2AK2 | CEP120 | 0.723826 | 3 | 0 | 3 |
| EIF2AK2 | CXCL2 | 0.72311 | 3 | 0 | 3 |
| EIF2AK2 | IFI6 | 0.723067 | 13 | 0 | 10 |
| EIF2AK2 | PARP12 | 0.722583 | 12 | 0 | 11 |
| EIF2AK2 | PYCR2 | 0.718437 | 3 | 0 | 3 |
| EIF2AK2 | FNDC3B | 0.715534 | 11 | 0 | 10 |
| EIF2AK2 | ASAP1 | 0.71456 | 11 | 0 | 11 |
| EIF2AK2 | DDX60 | 0.711848 | 12 | 0 | 11 |
| EIF2AK2 | FADS1 | 0.71059 | 3 | 0 | 3 |
| EIF2AK2 | STK3 | 0.710452 | 11 | 0 | 11 |
| EIF2AK2 | USP18 | 0.705323 | 13 | 0 | 12 |
| EIF2AK2 | LINC00674 | 0.705123 | 3 | 0 | 3 |
For details and further investigation, click here
