| Full name: leucine zipper tumor suppressor family member 3 | Alias Symbol: ProSAPiP1|KIAA0552 | ||
| Type: protein-coding gene | Cytoband: 20p13 | ||
| Entrez ID: 9762 | HGNC ID: HGNC:30139 | Ensembl Gene: ENSG00000088899 | OMIM ID: 610484 |
| Drug and gene relationship at DGIdb | |||
Expression of LZTS3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LZTS3 | 9762 | 204447_at | 0.6634 | 0.1636 | |
| GSE20347 | LZTS3 | 9762 | 204447_at | 0.6180 | 0.0000 | |
| GSE23400 | LZTS3 | 9762 | 204447_at | 0.1168 | 0.0112 | |
| GSE26886 | LZTS3 | 9762 | 204447_at | 0.5238 | 0.0110 | |
| GSE29001 | LZTS3 | 9762 | 204447_at | 0.1092 | 0.6921 | |
| GSE38129 | LZTS3 | 9762 | 204447_at | 0.4322 | 0.0130 | |
| GSE45670 | LZTS3 | 9762 | 204447_at | 0.3044 | 0.2316 | |
| GSE53622 | LZTS3 | 9762 | 61565 | 0.2483 | 0.1030 | |
| GSE53624 | LZTS3 | 9762 | 61565 | 0.5408 | 0.0000 | |
| GSE63941 | LZTS3 | 9762 | 204447_at | -0.1254 | 0.8216 | |
| GSE77861 | LZTS3 | 9762 | 204447_at | 0.2037 | 0.1731 | |
| SRP007169 | LZTS3 | 9762 | RNAseq | 1.4104 | 0.1038 | |
| SRP064894 | LZTS3 | 9762 | RNAseq | 0.2356 | 0.4196 | |
| SRP133303 | LZTS3 | 9762 | RNAseq | -0.1464 | 0.6244 | |
| SRP159526 | LZTS3 | 9762 | RNAseq | 1.3391 | 0.0038 | |
| SRP193095 | LZTS3 | 9762 | RNAseq | 0.8356 | 0.0081 | |
| SRP219564 | LZTS3 | 9762 | RNAseq | 0.3546 | 0.5827 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by LZTS3 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of LZTS3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LZTS3 | 9762 | 12 | 3 | 15 | |
| GSE20123 | LZTS3 | 9762 | 13 | 3 | 14 | |
| GSE43470 | LZTS3 | 9762 | 10 | 1 | 32 | |
| GSE46452 | LZTS3 | 9762 | 26 | 1 | 32 | |
| GSE47630 | LZTS3 | 9762 | 18 | 4 | 18 | |
| GSE54993 | LZTS3 | 9762 | 2 | 14 | 54 | |
| GSE54994 | LZTS3 | 9762 | 24 | 2 | 27 | |
| GSE60625 | LZTS3 | 9762 | 0 | 0 | 11 | |
| GSE74703 | LZTS3 | 9762 | 9 | 1 | 26 | |
| GSE74704 | LZTS3 | 9762 | 8 | 1 | 11 | |
| TCGA | LZTS3 | 9762 | 40 | 11 | 45 |
Total number of gains: 162; Total number of losses: 41; Total Number of normals: 285.
Somatic mutations of LZTS3:
Generating mutation plots.
Highly correlated genes for LZTS3:
Showing top 20/336 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LZTS3 | APCDD1L | 0.717681 | 3 | 0 | 3 |
| LZTS3 | ANKRD23 | 0.705963 | 4 | 0 | 3 |
| LZTS3 | TNRC18 | 0.705354 | 3 | 0 | 3 |
| LZTS3 | CHD3 | 0.697489 | 4 | 0 | 4 |
| LZTS3 | RTKN | 0.696088 | 3 | 0 | 3 |
| LZTS3 | ERH | 0.684368 | 3 | 0 | 3 |
| LZTS3 | CACTIN | 0.684174 | 5 | 0 | 5 |
| LZTS3 | KCNQ1OT1 | 0.682856 | 3 | 0 | 3 |
| LZTS3 | COA6 | 0.669941 | 3 | 0 | 3 |
| LZTS3 | PAGR1 | 0.663673 | 3 | 0 | 3 |
| LZTS3 | MNT | 0.65176 | 3 | 0 | 3 |
| LZTS3 | SIX5 | 0.650483 | 3 | 0 | 3 |
| LZTS3 | TMEM132A | 0.649708 | 5 | 0 | 4 |
| LZTS3 | BCAM | 0.64831 | 6 | 0 | 4 |
| LZTS3 | ZNF579 | 0.642542 | 4 | 0 | 3 |
| LZTS3 | HYOU1 | 0.64163 | 3 | 0 | 3 |
| LZTS3 | CDH4 | 0.635712 | 3 | 0 | 3 |
| LZTS3 | AP3B2 | 0.633039 | 4 | 0 | 3 |
| LZTS3 | MYNN | 0.632308 | 3 | 0 | 3 |
| LZTS3 | CD81 | 0.630628 | 4 | 0 | 4 |
For details and further investigation, click here
