| Full name: branched chain keto acid dehydrogenase E1 subunit beta | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6q14.1 | ||
| Entrez ID: 594 | HGNC ID: HGNC:987 | Ensembl Gene: ENSG00000083123 | OMIM ID: 248611 |
| Drug and gene relationship at DGIdb | |||
Expression of BCKDHB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BCKDHB | 594 | 213321_at | -0.4444 | 0.2306 | |
| GSE20347 | BCKDHB | 594 | 213321_at | -0.1625 | 0.0883 | |
| GSE23400 | BCKDHB | 594 | 213321_at | -0.1148 | 0.0001 | |
| GSE26886 | BCKDHB | 594 | 213321_at | -0.4841 | 0.0051 | |
| GSE29001 | BCKDHB | 594 | 213321_at | -0.1394 | 0.2486 | |
| GSE38129 | BCKDHB | 594 | 213321_at | -0.2464 | 0.0073 | |
| GSE45670 | BCKDHB | 594 | 210653_s_at | -1.0915 | 0.0000 | |
| GSE53622 | BCKDHB | 594 | 84131 | -0.7311 | 0.0000 | |
| GSE53624 | BCKDHB | 594 | 84131 | -0.9035 | 0.0000 | |
| GSE63941 | BCKDHB | 594 | 210653_s_at | 0.1629 | 0.8047 | |
| GSE77861 | BCKDHB | 594 | 213321_at | -0.2014 | 0.1820 | |
| GSE97050 | BCKDHB | 594 | A_23_P93464 | -0.4299 | 0.2605 | |
| SRP007169 | BCKDHB | 594 | RNAseq | -0.8789 | 0.0421 | |
| SRP008496 | BCKDHB | 594 | RNAseq | -0.9339 | 0.0019 | |
| SRP064894 | BCKDHB | 594 | RNAseq | -0.8487 | 0.0000 | |
| SRP133303 | BCKDHB | 594 | RNAseq | -0.6798 | 0.0000 | |
| SRP159526 | BCKDHB | 594 | RNAseq | -1.1129 | 0.0063 | |
| SRP193095 | BCKDHB | 594 | RNAseq | -0.9815 | 0.0000 | |
| SRP219564 | BCKDHB | 594 | RNAseq | -0.8277 | 0.0036 | |
| TCGA | BCKDHB | 594 | RNAseq | -0.6366 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by BCKDHB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BCKDHB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BCKDHB | 594 | 1 | 4 | 25 | |
| GSE20123 | BCKDHB | 594 | 1 | 3 | 26 | |
| GSE43470 | BCKDHB | 594 | 2 | 1 | 40 | |
| GSE46452 | BCKDHB | 594 | 2 | 11 | 46 | |
| GSE47630 | BCKDHB | 594 | 8 | 6 | 26 | |
| GSE54993 | BCKDHB | 594 | 3 | 2 | 65 | |
| GSE54994 | BCKDHB | 594 | 8 | 7 | 38 | |
| GSE60625 | BCKDHB | 594 | 0 | 1 | 10 | |
| GSE74703 | BCKDHB | 594 | 2 | 1 | 33 | |
| GSE74704 | BCKDHB | 594 | 0 | 2 | 18 | |
| TCGA | BCKDHB | 594 | 6 | 21 | 69 |
Total number of gains: 33; Total number of losses: 59; Total Number of normals: 396.
Somatic mutations of BCKDHB:
Generating mutation plots.
Highly correlated genes for BCKDHB:
Showing top 20/905 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BCKDHB | PLEKHH2 | 0.706172 | 4 | 0 | 4 |
| BCKDHB | KIF5A | 0.685246 | 3 | 0 | 3 |
| BCKDHB | RGS7BP | 0.683485 | 6 | 0 | 6 |
| BCKDHB | ANGPTL1 | 0.68007 | 5 | 0 | 5 |
| BCKDHB | RAB9B | 0.679201 | 5 | 0 | 5 |
| BCKDHB | RBPMS2 | 0.678558 | 5 | 0 | 5 |
| BCKDHB | RNF150 | 0.675224 | 5 | 0 | 5 |
| BCKDHB | KCNB1 | 0.674371 | 6 | 0 | 6 |
| BCKDHB | ANO5 | 0.67188 | 5 | 0 | 5 |
| BCKDHB | RPP30 | 0.66774 | 3 | 0 | 3 |
| BCKDHB | FILIP1 | 0.665748 | 3 | 0 | 3 |
| BCKDHB | GNAO1 | 0.661849 | 3 | 0 | 3 |
| BCKDHB | NEGR1 | 0.661005 | 5 | 0 | 5 |
| BCKDHB | C7 | 0.657082 | 6 | 0 | 6 |
| BCKDHB | SLC4A4 | 0.654525 | 7 | 0 | 6 |
| BCKDHB | PPARGC1A | 0.65329 | 5 | 0 | 5 |
| BCKDHB | C14orf28 | 0.651738 | 6 | 0 | 5 |
| BCKDHB | TCF21 | 0.651287 | 6 | 0 | 5 |
| BCKDHB | KAT6B | 0.646622 | 8 | 0 | 7 |
| BCKDHB | ATP1A2 | 0.645535 | 7 | 0 | 6 |
For details and further investigation, click here
