TDP1

 

Full name: tyrosyl-DNA phosphodiesterase 1 Alias Symbol: FLJ11090|SCAN1
Type: protein-coding gene Cytoband: 14q32.11
Entrez ID: 55775 HGNC ID: HGNC:18884 Ensembl Gene: ENSG00000042088 OMIM ID: 607198
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of TDP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TDP1 55775 219715_s_at 0.6330 0.1655
GSE20347 TDP1 55775 219715_s_at 0.4849 0.0003
GSE23400 TDP1 55775 219715_s_at 0.3295 0.0000
GSE26886 TDP1 55775 219715_s_at 0.3954 0.0903
GSE29001 TDP1 55775 219715_s_at 0.4033 0.0447
GSE38129 TDP1 55775 219715_s_at 0.7494 0.0000
GSE45670 TDP1 55775 219715_s_at 0.7631 0.0000
GSE53622 TDP1 55775 44854 0.2976 0.0007
GSE53624 TDP1 55775 44854 0.7513 0.0000
GSE63941 TDP1 55775 219715_s_at 1.5644 0.0011
GSE77861 TDP1 55775 219715_s_at 0.2302 0.5943
GSE97050 TDP1 55775 A_33_P3766959 0.7190 0.1507
SRP007169 TDP1 55775 RNAseq -0.1289 0.7286
SRP008496 TDP1 55775 RNAseq -0.0247 0.9172
SRP064894 TDP1 55775 RNAseq 0.4573 0.0003
SRP133303 TDP1 55775 RNAseq 0.2766 0.0004
SRP159526 TDP1 55775 RNAseq 0.1805 0.5109
SRP193095 TDP1 55775 RNAseq 0.1309 0.1176
SRP219564 TDP1 55775 RNAseq 0.4252 0.2713
TCGA TDP1 55775 RNAseq 0.2922 0.0000

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by TDP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TDP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TDP1 55775 9 5 16
GSE20123 TDP1 55775 9 5 16
GSE43470 TDP1 55775 7 3 33
GSE46452 TDP1 55775 16 3 40
GSE47630 TDP1 55775 11 8 21
GSE54993 TDP1 55775 3 8 59
GSE54994 TDP1 55775 19 4 30
GSE60625 TDP1 55775 0 2 9
GSE74703 TDP1 55775 6 3 27
GSE74704 TDP1 55775 4 4 12
TCGA TDP1 55775 32 21 43

Total number of gains: 116; Total number of losses: 66; Total Number of normals: 306.  

 

Somatic mutations of TDP1:

 

Generating mutation plots.

 

Highly correlated genes for TDP1:

 

Showing top 20/1129 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TDP1KLHL280.88985303
TDP1CENPBD10.792943303
TDP1BOLA30.791942303
TDP1LRRC580.773814303
TDP1DCXR0.766531303
TDP1GPR1600.759327303
TDP1FCGR3A0.754021303
TDP1CDCA20.745498505
TDP1EME10.738351404
TDP1CCNB20.737923909
TDP1PILRA0.731123303
TDP1ZDHHC160.730751505
TDP1TIMELESS0.72767810010
TDP1CDCA40.72659612011
TDP1TMX10.72267410010
TDP1DMAP10.721108303
TDP1TTK0.71635310010
TDP1PBK0.7156151009
TDP1EFTUD20.711848606
TDP1CEP410.711234404

For details and further investigation, click here