| Full name: protein phosphatase 2 regulatory subunit B''alpha | Alias Symbol: PR130|PR72 | ||
| Type: protein-coding gene | Cytoband: 3q22.2-q22.3 | ||
| Entrez ID: 5523 | HGNC ID: HGNC:9307 | Ensembl Gene: ENSG00000073711 | OMIM ID: 604944 |
| Drug and gene relationship at DGIdb | |||
PPP2R3A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04071 | Sphingolipid signaling pathway | |
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04261 | Adrenergic signaling in cardiomyocytes | |
| hsa04728 | Dopaminergic synapse |
Expression of PPP2R3A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP2R3A | 5523 | 209633_at | 0.0875 | 0.8529 | |
| GSE20347 | PPP2R3A | 5523 | 209633_at | -0.1770 | 0.3172 | |
| GSE23400 | PPP2R3A | 5523 | 209633_at | 0.1606 | 0.0049 | |
| GSE26886 | PPP2R3A | 5523 | 209633_at | 0.1160 | 0.6946 | |
| GSE29001 | PPP2R3A | 5523 | 209633_at | 0.3784 | 0.1512 | |
| GSE38129 | PPP2R3A | 5523 | 209633_at | -0.2548 | 0.0757 | |
| GSE45670 | PPP2R3A | 5523 | 209633_at | 0.3621 | 0.0364 | |
| GSE53622 | PPP2R3A | 5523 | 88664 | -0.2292 | 0.0265 | |
| GSE53624 | PPP2R3A | 5523 | 88664 | 0.0841 | 0.3868 | |
| GSE63941 | PPP2R3A | 5523 | 207749_s_at | 0.9501 | 0.2545 | |
| GSE77861 | PPP2R3A | 5523 | 209633_at | 0.2091 | 0.6002 | |
| GSE97050 | PPP2R3A | 5523 | A_24_P388433 | -0.3997 | 0.2395 | |
| SRP007169 | PPP2R3A | 5523 | RNAseq | 0.5506 | 0.1934 | |
| SRP008496 | PPP2R3A | 5523 | RNAseq | 0.7462 | 0.0003 | |
| SRP064894 | PPP2R3A | 5523 | RNAseq | 0.3682 | 0.0454 | |
| SRP133303 | PPP2R3A | 5523 | RNAseq | 0.3526 | 0.0946 | |
| SRP159526 | PPP2R3A | 5523 | RNAseq | 0.7354 | 0.0492 | |
| SRP193095 | PPP2R3A | 5523 | RNAseq | 0.2396 | 0.1469 | |
| SRP219564 | PPP2R3A | 5523 | RNAseq | -0.3936 | 0.1110 | |
| TCGA | PPP2R3A | 5523 | RNAseq | -0.1814 | 0.0217 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PPP2R3A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP2R3A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP2R3A | 5523 | 16 | 0 | 14 | |
| GSE20123 | PPP2R3A | 5523 | 16 | 0 | 14 | |
| GSE43470 | PPP2R3A | 5523 | 22 | 0 | 21 | |
| GSE46452 | PPP2R3A | 5523 | 15 | 4 | 40 | |
| GSE47630 | PPP2R3A | 5523 | 18 | 3 | 19 | |
| GSE54993 | PPP2R3A | 5523 | 2 | 8 | 60 | |
| GSE54994 | PPP2R3A | 5523 | 32 | 1 | 20 | |
| GSE60625 | PPP2R3A | 5523 | 0 | 6 | 5 | |
| GSE74703 | PPP2R3A | 5523 | 19 | 0 | 17 | |
| GSE74704 | PPP2R3A | 5523 | 11 | 0 | 9 | |
| TCGA | PPP2R3A | 5523 | 60 | 5 | 31 |
Total number of gains: 211; Total number of losses: 27; Total Number of normals: 250.
Somatic mutations of PPP2R3A:
Generating mutation plots.
Highly correlated genes for PPP2R3A:
Showing top 20/93 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP2R3A | RAB3GAP1 | 0.773346 | 3 | 0 | 3 |
| PPP2R3A | RAB12 | 0.771694 | 3 | 0 | 3 |
| PPP2R3A | XRRA1 | 0.770647 | 3 | 0 | 3 |
| PPP2R3A | MYO3B | 0.76858 | 3 | 0 | 3 |
| PPP2R3A | SLC35E1 | 0.725259 | 3 | 0 | 3 |
| PPP2R3A | KLHL28 | 0.715924 | 3 | 0 | 3 |
| PPP2R3A | PSMC1 | 0.709704 | 3 | 0 | 3 |
| PPP2R3A | NEK7 | 0.708605 | 3 | 0 | 3 |
| PPP2R3A | LRRFIP1 | 0.69972 | 3 | 0 | 3 |
| PPP2R3A | ARL13B | 0.67532 | 4 | 0 | 4 |
| PPP2R3A | RTN1 | 0.664769 | 3 | 0 | 3 |
| PPP2R3A | SEC23A | 0.664681 | 3 | 0 | 3 |
| PPP2R3A | ADO | 0.657032 | 3 | 0 | 3 |
| PPP2R3A | NAPG | 0.654603 | 4 | 0 | 3 |
| PPP2R3A | GSK3B | 0.654404 | 4 | 0 | 3 |
| PPP2R3A | FBXL4 | 0.652429 | 3 | 0 | 3 |
| PPP2R3A | AP4S1 | 0.645658 | 4 | 0 | 3 |
| PPP2R3A | VPS13B | 0.636362 | 3 | 0 | 3 |
| PPP2R3A | ATG10 | 0.634483 | 5 | 0 | 3 |
| PPP2R3A | TOMM40L | 0.630079 | 4 | 0 | 3 |
For details and further investigation, click here
