| Full name: guanylate binding protein 5 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p22.2 | ||
| Entrez ID: 115362 | HGNC ID: HGNC:19895 | Ensembl Gene: ENSG00000154451 | OMIM ID: 611467 |
| Drug and gene relationship at DGIdb | |||
Expression of GBP5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GBP5 | 115362 | 229625_at | 1.4920 | 0.1310 | |
| GSE26886 | GBP5 | 115362 | 238581_at | -0.0271 | 0.9669 | |
| GSE45670 | GBP5 | 115362 | 229625_at | 1.2099 | 0.0047 | |
| GSE53622 | GBP5 | 115362 | 92756 | 0.2972 | 0.0594 | |
| GSE53624 | GBP5 | 115362 | 92756 | 0.1629 | 0.1467 | |
| GSE63941 | GBP5 | 115362 | 229625_at | 0.4045 | 0.6985 | |
| GSE77861 | GBP5 | 115362 | 229625_at | 0.2519 | 0.2481 | |
| GSE97050 | GBP5 | 115362 | A_23_P74290 | 0.3353 | 0.6542 | |
| SRP007169 | GBP5 | 115362 | RNAseq | 2.1013 | 0.0022 | |
| SRP008496 | GBP5 | 115362 | RNAseq | 1.4503 | 0.0038 | |
| SRP064894 | GBP5 | 115362 | RNAseq | 2.5153 | 0.0000 | |
| SRP133303 | GBP5 | 115362 | RNAseq | 2.1413 | 0.0000 | |
| SRP159526 | GBP5 | 115362 | RNAseq | 0.6337 | 0.4614 | |
| SRP193095 | GBP5 | 115362 | RNAseq | 1.5697 | 0.0000 | |
| SRP219564 | GBP5 | 115362 | RNAseq | 4.3601 | 0.0000 | |
| TCGA | GBP5 | 115362 | RNAseq | 1.1198 | 0.0000 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by GBP5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GBP5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GBP5 | 115362 | 0 | 8 | 22 | |
| GSE20123 | GBP5 | 115362 | 0 | 8 | 22 | |
| GSE43470 | GBP5 | 115362 | 2 | 2 | 39 | |
| GSE46452 | GBP5 | 115362 | 1 | 1 | 57 | |
| GSE47630 | GBP5 | 115362 | 8 | 5 | 27 | |
| GSE54993 | GBP5 | 115362 | 0 | 1 | 69 | |
| GSE54994 | GBP5 | 115362 | 6 | 2 | 45 | |
| GSE60625 | GBP5 | 115362 | 0 | 0 | 11 | |
| GSE74703 | GBP5 | 115362 | 1 | 2 | 33 | |
| GSE74704 | GBP5 | 115362 | 0 | 5 | 15 | |
| TCGA | GBP5 | 115362 | 6 | 23 | 67 |
Total number of gains: 24; Total number of losses: 57; Total Number of normals: 407.
Somatic mutations of GBP5:
Generating mutation plots.
Highly correlated genes for GBP5:
Showing top 20/201 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GBP5 | BRIX1 | 0.744463 | 3 | 0 | 3 |
| GBP5 | BRD9 | 0.743298 | 3 | 0 | 3 |
| GBP5 | NUP155 | 0.742352 | 3 | 0 | 3 |
| GBP5 | BYSL | 0.738763 | 3 | 0 | 3 |
| GBP5 | HSP90B1 | 0.7246 | 3 | 0 | 3 |
| GBP5 | CLPTM1L | 0.700933 | 3 | 0 | 3 |
| GBP5 | TAP1 | 0.700763 | 5 | 0 | 5 |
| GBP5 | VNN3 | 0.695439 | 3 | 0 | 3 |
| GBP5 | PSMB9 | 0.693263 | 6 | 0 | 6 |
| GBP5 | RPN2 | 0.685389 | 3 | 0 | 3 |
| GBP5 | SLC12A7 | 0.67516 | 3 | 0 | 3 |
| GBP5 | NOC4L | 0.673378 | 3 | 0 | 3 |
| GBP5 | TRAM1 | 0.670742 | 3 | 0 | 3 |
| GBP5 | ABCF1 | 0.667346 | 3 | 0 | 3 |
| GBP5 | KLRC4 | 0.666083 | 3 | 0 | 3 |
| GBP5 | GNL1 | 0.664044 | 4 | 0 | 3 |
| GBP5 | ICE1 | 0.662021 | 3 | 0 | 3 |
| GBP5 | GBP1 | 0.659732 | 6 | 0 | 5 |
| GBP5 | DCAF13 | 0.655448 | 3 | 0 | 3 |
| GBP5 | CYP27B1 | 0.653334 | 3 | 0 | 3 |
For details and further investigation, click here
