| Full name: keratin 12 | Alias Symbol: K12 | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 3859 | HGNC ID: HGNC:6414 | Ensembl Gene: ENSG00000187242 | OMIM ID: 601687 |
| Drug and gene relationship at DGIdb | |||
Expression of KRT12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KRT12 | 3859 | 207811_at | -0.0874 | 0.6752 | |
| GSE20347 | KRT12 | 3859 | 207811_at | 0.0435 | 0.4552 | |
| GSE23400 | KRT12 | 3859 | 207811_at | -0.0046 | 0.8857 | |
| GSE26886 | KRT12 | 3859 | 207811_at | 0.2053 | 0.0385 | |
| GSE29001 | KRT12 | 3859 | 207811_at | -0.1906 | 0.1640 | |
| GSE38129 | KRT12 | 3859 | 207811_at | 0.0003 | 0.9974 | |
| GSE45670 | KRT12 | 3859 | 207811_at | 0.1931 | 0.0198 | |
| GSE63941 | KRT12 | 3859 | 207811_at | 0.1114 | 0.4737 | |
| GSE77861 | KRT12 | 3859 | 207811_at | -0.0633 | 0.4083 | |
| TCGA | KRT12 | 3859 | RNAseq | -2.6180 | 0.0325 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by KRT12 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of KRT12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KRT12 | 3859 | 7 | 1 | 22 | |
| GSE20123 | KRT12 | 3859 | 7 | 1 | 22 | |
| GSE43470 | KRT12 | 3859 | 1 | 2 | 40 | |
| GSE46452 | KRT12 | 3859 | 34 | 0 | 25 | |
| GSE47630 | KRT12 | 3859 | 8 | 1 | 31 | |
| GSE54993 | KRT12 | 3859 | 3 | 4 | 63 | |
| GSE54994 | KRT12 | 3859 | 8 | 5 | 40 | |
| GSE60625 | KRT12 | 3859 | 4 | 0 | 7 | |
| GSE74703 | KRT12 | 3859 | 1 | 1 | 34 | |
| GSE74704 | KRT12 | 3859 | 5 | 1 | 14 | |
| TCGA | KRT12 | 3859 | 22 | 8 | 66 |
Total number of gains: 100; Total number of losses: 24; Total Number of normals: 364.
Somatic mutations of KRT12:
Generating mutation plots.
Highly correlated genes for KRT12:
Showing top 20/281 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KRT12 | FOLH1 | 0.718846 | 6 | 0 | 6 |
| KRT12 | RIT2 | 0.667669 | 4 | 0 | 3 |
| KRT12 | RORC | 0.661687 | 3 | 0 | 3 |
| KRT12 | RAPGEF3 | 0.659313 | 3 | 0 | 3 |
| KRT12 | GAL3ST1 | 0.643125 | 3 | 0 | 3 |
| KRT12 | CCDC7 | 0.639582 | 4 | 0 | 3 |
| KRT12 | EPHA6 | 0.638855 | 3 | 0 | 3 |
| KRT12 | CDY1 | 0.637429 | 3 | 0 | 3 |
| KRT12 | KRT38 | 0.635239 | 4 | 0 | 4 |
| KRT12 | OR2B2 | 0.631794 | 6 | 0 | 4 |
| KRT12 | GPR12 | 0.628739 | 4 | 0 | 4 |
| KRT12 | EPN1 | 0.62424 | 3 | 0 | 3 |
| KRT12 | MAPK4 | 0.622619 | 4 | 0 | 3 |
| KRT12 | FGF21 | 0.62107 | 3 | 0 | 3 |
| KRT12 | CBL | 0.620798 | 4 | 0 | 4 |
| KRT12 | TERT | 0.619025 | 4 | 0 | 3 |
| KRT12 | SMCP | 0.615223 | 5 | 0 | 3 |
| KRT12 | GDNF | 0.614297 | 3 | 0 | 3 |
| KRT12 | NYX | 0.613415 | 5 | 0 | 4 |
| KRT12 | NTNG1 | 0.610206 | 4 | 0 | 3 |
For details and further investigation, click here
