| Full name: keratin 7 | Alias Symbol: K7|CK7|K2C7|SCL | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 3855 | HGNC ID: HGNC:6445 | Ensembl Gene: ENSG00000135480 | OMIM ID: 148059 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of KRT7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KRT7 | 3855 | 209016_s_at | -0.8053 | 0.6998 | |
| GSE20347 | KRT7 | 3855 | 209016_s_at | -0.7690 | 0.1677 | |
| GSE23400 | KRT7 | 3855 | 209016_s_at | -1.0022 | 0.0002 | |
| GSE26886 | KRT7 | 3855 | 1558393_at | -0.0511 | 0.8113 | |
| GSE29001 | KRT7 | 3855 | 209016_s_at | -0.1428 | 0.9001 | |
| GSE38129 | KRT7 | 3855 | 209016_s_at | -0.5750 | 0.1857 | |
| GSE45670 | KRT7 | 3855 | 209016_s_at | -0.8106 | 0.1391 | |
| GSE53622 | KRT7 | 3855 | 138118 | -0.4986 | 0.0001 | |
| GSE53624 | KRT7 | 3855 | 138118 | -0.7104 | 0.0000 | |
| GSE63941 | KRT7 | 3855 | 209016_s_at | 0.6088 | 0.7587 | |
| GSE77861 | KRT7 | 3855 | 1558393_at | -0.2333 | 0.0114 | |
| GSE97050 | KRT7 | 3855 | A_33_P3350748 | 0.7402 | 0.1450 | |
| SRP007169 | KRT7 | 3855 | RNAseq | -1.7105 | 0.0835 | |
| SRP008496 | KRT7 | 3855 | RNAseq | -1.7689 | 0.1320 | |
| SRP064894 | KRT7 | 3855 | RNAseq | -1.2741 | 0.0841 | |
| SRP133303 | KRT7 | 3855 | RNAseq | -1.6783 | 0.0092 | |
| SRP159526 | KRT7 | 3855 | RNAseq | -2.0511 | 0.0181 | |
| SRP193095 | KRT7 | 3855 | RNAseq | -0.0615 | 0.9153 | |
| SRP219564 | KRT7 | 3855 | RNAseq | -2.3515 | 0.0217 | |
| TCGA | KRT7 | 3855 | RNAseq | 0.0180 | 0.9588 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by KRT7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KRT7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KRT7 | 3855 | 8 | 1 | 21 | |
| GSE20123 | KRT7 | 3855 | 8 | 1 | 21 | |
| GSE43470 | KRT7 | 3855 | 3 | 0 | 40 | |
| GSE46452 | KRT7 | 3855 | 7 | 1 | 51 | |
| GSE47630 | KRT7 | 3855 | 10 | 2 | 28 | |
| GSE54993 | KRT7 | 3855 | 0 | 5 | 65 | |
| GSE54994 | KRT7 | 3855 | 3 | 2 | 48 | |
| GSE60625 | KRT7 | 3855 | 0 | 0 | 11 | |
| GSE74703 | KRT7 | 3855 | 3 | 0 | 33 | |
| GSE74704 | KRT7 | 3855 | 5 | 1 | 14 | |
| TCGA | KRT7 | 3855 | 12 | 11 | 73 |
Total number of gains: 59; Total number of losses: 24; Total Number of normals: 405.
Somatic mutations of KRT7:
Generating mutation plots.
Highly correlated genes for KRT7:
Showing top 20/95 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KRT7 | COL9A2 | 0.72708 | 3 | 0 | 3 |
| KRT7 | NIPSNAP3A | 0.641365 | 3 | 0 | 3 |
| KRT7 | CTTNBP2NL | 0.63115 | 3 | 0 | 3 |
| KRT7 | MACC1 | 0.627039 | 7 | 0 | 4 |
| KRT7 | ACAA1 | 0.625095 | 3 | 0 | 3 |
| KRT7 | DCDC2 | 0.612958 | 4 | 0 | 3 |
| KRT7 | SLAMF6 | 0.611565 | 3 | 0 | 3 |
| KRT7 | ASB10 | 0.603797 | 3 | 0 | 3 |
| KRT7 | IKZF2 | 0.603529 | 6 | 0 | 5 |
| KRT7 | EML3 | 0.602741 | 4 | 0 | 3 |
| KRT7 | ZNF626 | 0.599658 | 3 | 0 | 3 |
| KRT7 | DCXR | 0.597093 | 3 | 0 | 3 |
| KRT7 | GPRC5A | 0.592992 | 5 | 0 | 4 |
| KRT7 | CCNB3 | 0.589163 | 3 | 0 | 3 |
| KRT7 | LINC01192 | 0.588107 | 4 | 0 | 4 |
| KRT7 | FCRLA | 0.587832 | 3 | 0 | 3 |
| KRT7 | VPS52 | 0.586497 | 4 | 0 | 3 |
| KRT7 | VSIG2 | 0.584527 | 6 | 0 | 4 |
| KRT7 | BCAS1 | 0.582871 | 7 | 0 | 3 |
| KRT7 | RABEP2 | 0.579948 | 5 | 0 | 3 |
For details and further investigation, click here
