| Full name: leucine aminopeptidase 3 | Alias Symbol: LAPEP|LAP | ||
| Type: protein-coding gene | Cytoband: 4p15.32 | ||
| Entrez ID: 51056 | HGNC ID: HGNC:18449 | Ensembl Gene: ENSG00000002549 | OMIM ID: 170250 |
| Drug and gene relationship at DGIdb | |||
Expression of LAP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LAP3 | 51056 | 217933_s_at | 0.0917 | 0.9069 | |
| GSE20347 | LAP3 | 51056 | 217933_s_at | 0.2106 | 0.4004 | |
| GSE23400 | LAP3 | 51056 | 217933_s_at | 0.5942 | 0.0000 | |
| GSE26886 | LAP3 | 51056 | 217933_s_at | -0.3488 | 0.2678 | |
| GSE29001 | LAP3 | 51056 | 217933_s_at | 0.8286 | 0.0566 | |
| GSE38129 | LAP3 | 51056 | 217933_s_at | 0.2885 | 0.2039 | |
| GSE45670 | LAP3 | 51056 | 217933_s_at | 0.4272 | 0.0990 | |
| GSE53622 | LAP3 | 51056 | 46396 | 0.3724 | 0.0005 | |
| GSE53624 | LAP3 | 51056 | 46396 | 0.5047 | 0.0000 | |
| GSE63941 | LAP3 | 51056 | 217933_s_at | -0.7415 | 0.1466 | |
| GSE77861 | LAP3 | 51056 | 217933_s_at | -0.0676 | 0.8010 | |
| GSE97050 | LAP3 | 51056 | A_23_P18604 | 0.5767 | 0.2276 | |
| SRP007169 | LAP3 | 51056 | RNAseq | 0.5659 | 0.1888 | |
| SRP008496 | LAP3 | 51056 | RNAseq | 0.2026 | 0.4944 | |
| SRP064894 | LAP3 | 51056 | RNAseq | 0.6341 | 0.0000 | |
| SRP133303 | LAP3 | 51056 | RNAseq | 0.4434 | 0.0586 | |
| SRP159526 | LAP3 | 51056 | RNAseq | -0.0857 | 0.8079 | |
| SRP193095 | LAP3 | 51056 | RNAseq | 0.0248 | 0.8430 | |
| SRP219564 | LAP3 | 51056 | RNAseq | 0.2684 | 0.5771 | |
| TCGA | LAP3 | 51056 | RNAseq | 0.0425 | 0.4836 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LAP3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LAP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LAP3 | 51056 | 0 | 18 | 12 | |
| GSE20123 | LAP3 | 51056 | 0 | 18 | 12 | |
| GSE43470 | LAP3 | 51056 | 1 | 15 | 27 | |
| GSE46452 | LAP3 | 51056 | 1 | 36 | 22 | |
| GSE47630 | LAP3 | 51056 | 1 | 19 | 20 | |
| GSE54993 | LAP3 | 51056 | 9 | 0 | 61 | |
| GSE54994 | LAP3 | 51056 | 4 | 12 | 37 | |
| GSE60625 | LAP3 | 51056 | 0 | 0 | 11 | |
| GSE74703 | LAP3 | 51056 | 1 | 13 | 22 | |
| GSE74704 | LAP3 | 51056 | 0 | 11 | 9 | |
| TCGA | LAP3 | 51056 | 9 | 48 | 39 |
Total number of gains: 26; Total number of losses: 190; Total Number of normals: 272.
Somatic mutations of LAP3:
Generating mutation plots.
Highly correlated genes for LAP3:
Showing top 20/634 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LAP3 | MRPS35 | 0.758295 | 3 | 0 | 3 |
| LAP3 | NOSIP | 0.750876 | 3 | 0 | 3 |
| LAP3 | TIMM8A | 0.73651 | 3 | 0 | 3 |
| LAP3 | PSMB8-AS1 | 0.736492 | 4 | 0 | 4 |
| LAP3 | SMAP2 | 0.730148 | 3 | 0 | 3 |
| LAP3 | MTIF2 | 0.717457 | 3 | 0 | 3 |
| LAP3 | GPR141 | 0.712348 | 3 | 0 | 3 |
| LAP3 | RNASEH1 | 0.708686 | 4 | 0 | 4 |
| LAP3 | NLK | 0.705772 | 3 | 0 | 3 |
| LAP3 | EPSTI1 | 0.705186 | 7 | 0 | 6 |
| LAP3 | ZFYVE26 | 0.704015 | 3 | 0 | 3 |
| LAP3 | MAGOHB | 0.697407 | 4 | 0 | 3 |
| LAP3 | ARHGAP18 | 0.696938 | 5 | 0 | 5 |
| LAP3 | IFI35 | 0.695288 | 9 | 0 | 9 |
| LAP3 | RPS16 | 0.694821 | 3 | 0 | 3 |
| LAP3 | NMI | 0.693327 | 11 | 0 | 10 |
| LAP3 | NDUFA5 | 0.692333 | 3 | 0 | 3 |
| LAP3 | BCCIP | 0.691256 | 3 | 0 | 3 |
| LAP3 | OSTC | 0.688808 | 3 | 0 | 3 |
| LAP3 | FLT3LG | 0.676204 | 3 | 0 | 3 |
For details and further investigation, click here
