CENPE

 

Full name: centromere protein E Alias Symbol: KIF10|PPP1R61
Type: protein-coding gene Cytoband: 4q24
Entrez ID: 1062 HGNC ID: HGNC:1856 Ensembl Gene: ENSG00000138778 OMIM ID: 117143
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of CENPE:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CENPE 1062 205046_at 1.4970 0.0194
GSE20347 CENPE 1062 205046_at 1.2592 0.0000
GSE23400 CENPE 1062 205046_at 0.5787 0.0000
GSE26886 CENPE 1062 205046_at 0.8075 0.0100
GSE29001 CENPE 1062 205046_at 1.0732 0.0027
GSE38129 CENPE 1062 205046_at 1.5946 0.0000
GSE45670 CENPE 1062 205046_at 1.2683 0.0000
GSE53622 CENPE 1062 90823 1.5426 0.0000
GSE53624 CENPE 1062 90823 1.6191 0.0000
GSE63941 CENPE 1062 205046_at 0.7704 0.4158
GSE77861 CENPE 1062 205046_at 0.8213 0.0910
GSE97050 CENPE 1062 A_23_P253524 0.8561 0.1069
SRP007169 CENPE 1062 RNAseq 2.2528 0.0000
SRP008496 CENPE 1062 RNAseq 2.1752 0.0000
SRP064894 CENPE 1062 RNAseq 1.4968 0.0001
SRP133303 CENPE 1062 RNAseq 1.8882 0.0000
SRP159526 CENPE 1062 RNAseq 1.2612 0.0112
SRP193095 CENPE 1062 RNAseq 0.8936 0.0000
SRP219564 CENPE 1062 RNAseq 0.8576 0.1782
TCGA CENPE 1062 RNAseq 0.9395 0.0000

Upregulated datasets: 12; Downregulated datasets: 0.  

 

Survival by CENPE expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CENPE:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CENPE 1062 0 12 18
GSE20123 CENPE 1062 0 12 18
GSE43470 CENPE 1062 0 13 30
GSE46452 CENPE 1062 1 36 22
GSE47630 CENPE 1062 0 20 20
GSE54993 CENPE 1062 9 0 61
GSE54994 CENPE 1062 1 10 42
GSE60625 CENPE 1062 0 3 8
GSE74703 CENPE 1062 0 11 25
GSE74704 CENPE 1062 0 6 14
TCGA CENPE 1062 7 41 48

Total number of gains: 18; Total number of losses: 164; Total Number of normals: 306.  

 

Somatic mutations of CENPE:

 

Generating mutation plots.

 

Highly correlated genes for CENPE:

 

Showing top 20/2093 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CENPEASPM0.83977313012
CENPECENPF0.83571412012
CENPETTK0.82117912012
CENPECCNA20.81730113013
CENPETOP2A0.81535413013
CENPEBUB10.81320511011
CENPEKIF140.81270413012
CENPEGINS10.81179611011
CENPEANLN0.807887909
CENPEKIF230.80751613013
CENPEHJURP0.80587412011
CENPERACGAP10.80003611011
CENPEKIF20A0.79956813011
CENPEDLGAP50.79701612012
CENPECDKN30.79651513013
CENPENUF20.796353908
CENPEAURKA0.79529913012
CENPECEP550.79404413013
CENPESPAG50.79216313012
CENPENEK20.79196913011

For details and further investigation, click here