| Full name: ras homolog family member C | Alias Symbol: RhoC | ||
| Type: protein-coding gene | Cytoband: 1p13.2 | ||
| Entrez ID: 389 | HGNC ID: HGNC:669 | Ensembl Gene: ENSG00000155366 | OMIM ID: 165380 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of RHOC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RHOC | 389 | 235742_at | 0.3448 | 0.6279 | |
| GSE26886 | RHOC | 389 | 235742_at | 0.1964 | 0.2595 | |
| GSE45670 | RHOC | 389 | 235742_at | 0.2138 | 0.0800 | |
| GSE53622 | RHOC | 389 | 72181 | -0.1796 | 0.0084 | |
| GSE53624 | RHOC | 389 | 72181 | 0.2114 | 0.0000 | |
| GSE63941 | RHOC | 389 | 235742_at | 0.3820 | 0.2723 | |
| GSE77861 | RHOC | 389 | 235742_at | -0.0826 | 0.6074 | |
| GSE97050 | RHOC | 389 | A_23_P406424 | -0.1280 | 0.5396 | |
| SRP007169 | RHOC | 389 | RNAseq | 0.8501 | 0.0201 | |
| SRP008496 | RHOC | 389 | RNAseq | 0.9763 | 0.0002 | |
| SRP064894 | RHOC | 389 | RNAseq | 1.1602 | 0.0005 | |
| SRP133303 | RHOC | 389 | RNAseq | 1.0054 | 0.0000 | |
| SRP159526 | RHOC | 389 | RNAseq | 0.2951 | 0.0965 | |
| SRP193095 | RHOC | 389 | RNAseq | 0.3390 | 0.2169 | |
| SRP219564 | RHOC | 389 | RNAseq | 0.3434 | 0.5885 | |
| TCGA | RHOC | 389 | RNAseq | 0.0714 | 0.1794 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by RHOC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RHOC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RHOC | 389 | 0 | 10 | 20 | |
| GSE20123 | RHOC | 389 | 0 | 10 | 20 | |
| GSE43470 | RHOC | 389 | 0 | 8 | 35 | |
| GSE46452 | RHOC | 389 | 2 | 1 | 56 | |
| GSE47630 | RHOC | 389 | 9 | 5 | 26 | |
| GSE54993 | RHOC | 389 | 0 | 1 | 69 | |
| GSE54994 | RHOC | 389 | 7 | 4 | 42 | |
| GSE60625 | RHOC | 389 | 0 | 0 | 11 | |
| GSE74703 | RHOC | 389 | 0 | 7 | 29 | |
| GSE74704 | RHOC | 389 | 0 | 6 | 14 | |
| TCGA | RHOC | 389 | 8 | 27 | 61 |
Total number of gains: 26; Total number of losses: 79; Total Number of normals: 383.
Somatic mutations of RHOC:
Generating mutation plots.
Highly correlated genes for RHOC:
Showing top 20/99 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RHOC | USP48 | 0.733617 | 3 | 0 | 3 |
| RHOC | CD34 | 0.732157 | 3 | 0 | 3 |
| RHOC | LETM2 | 0.721209 | 3 | 0 | 3 |
| RHOC | DVL3 | 0.712134 | 3 | 0 | 3 |
| RHOC | ETV6 | 0.699396 | 3 | 0 | 3 |
| RHOC | WDR1 | 0.699354 | 3 | 0 | 3 |
| RHOC | NDUFA11 | 0.698877 | 3 | 0 | 3 |
| RHOC | PACS1 | 0.691085 | 3 | 0 | 3 |
| RHOC | DEDD | 0.688198 | 3 | 0 | 3 |
| RHOC | POLR2L | 0.686514 | 3 | 0 | 3 |
| RHOC | GDAP2 | 0.685232 | 3 | 0 | 3 |
| RHOC | MTCH1 | 0.681412 | 3 | 0 | 3 |
| RHOC | FKTN | 0.676868 | 3 | 0 | 3 |
| RHOC | MCMBP | 0.661692 | 3 | 0 | 3 |
| RHOC | TSHZ3 | 0.659251 | 4 | 0 | 4 |
| RHOC | NFXL1 | 0.658356 | 3 | 0 | 3 |
| RHOC | PCDH7 | 0.656644 | 4 | 0 | 3 |
| RHOC | OTUD3 | 0.656547 | 3 | 0 | 3 |
| RHOC | CHD4 | 0.651308 | 3 | 0 | 3 |
| RHOC | C9orf78 | 0.65046 | 3 | 0 | 3 |
For details and further investigation, click here
