| Full name: phospholysine phosphohistidine inorganic pyrophosphate phosphatase | Alias Symbol: HDHD2B | ||
| Type: protein-coding gene | Cytoband: 10q26.13 | ||
| Entrez ID: 64077 | HGNC ID: HGNC:30042 | Ensembl Gene: ENSG00000107902 | OMIM ID: 617231 |
| Drug and gene relationship at DGIdb | |||
Expression of LHPP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LHPP | 64077 | 218523_at | -0.1916 | 0.6135 | |
| GSE20347 | LHPP | 64077 | 218523_at | -0.6431 | 0.0002 | |
| GSE23400 | LHPP | 64077 | 218523_at | -0.4064 | 0.0000 | |
| GSE26886 | LHPP | 64077 | 218523_at | 0.2511 | 0.0682 | |
| GSE29001 | LHPP | 64077 | 218523_at | -0.6719 | 0.0057 | |
| GSE38129 | LHPP | 64077 | 218523_at | -0.7315 | 0.0000 | |
| GSE45670 | LHPP | 64077 | 218523_at | -0.2974 | 0.0343 | |
| GSE53622 | LHPP | 64077 | 38108 | -0.8470 | 0.0000 | |
| GSE53624 | LHPP | 64077 | 38108 | -0.8899 | 0.0000 | |
| GSE63941 | LHPP | 64077 | 218523_at | 0.6716 | 0.1426 | |
| GSE77861 | LHPP | 64077 | 218523_at | -0.7197 | 0.0038 | |
| GSE97050 | LHPP | 64077 | A_23_P75299 | -0.3721 | 0.1555 | |
| SRP007169 | LHPP | 64077 | RNAseq | -1.6865 | 0.0006 | |
| SRP008496 | LHPP | 64077 | RNAseq | -1.4608 | 0.0000 | |
| SRP064894 | LHPP | 64077 | RNAseq | -0.3681 | 0.1632 | |
| SRP133303 | LHPP | 64077 | RNAseq | -0.5714 | 0.0012 | |
| SRP159526 | LHPP | 64077 | RNAseq | -0.8729 | 0.0000 | |
| SRP193095 | LHPP | 64077 | RNAseq | -0.6075 | 0.0000 | |
| SRP219564 | LHPP | 64077 | RNAseq | -0.4763 | 0.1980 | |
| TCGA | LHPP | 64077 | RNAseq | -0.2045 | 0.0038 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by LHPP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LHPP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LHPP | 64077 | 1 | 8 | 21 | |
| GSE20123 | LHPP | 64077 | 1 | 8 | 21 | |
| GSE43470 | LHPP | 64077 | 0 | 10 | 33 | |
| GSE46452 | LHPP | 64077 | 0 | 11 | 48 | |
| GSE47630 | LHPP | 64077 | 2 | 14 | 24 | |
| GSE54993 | LHPP | 64077 | 8 | 1 | 61 | |
| GSE54994 | LHPP | 64077 | 2 | 8 | 43 | |
| GSE60625 | LHPP | 64077 | 0 | 0 | 11 | |
| GSE74703 | LHPP | 64077 | 0 | 6 | 30 | |
| GSE74704 | LHPP | 64077 | 1 | 3 | 16 | |
| TCGA | LHPP | 64077 | 5 | 27 | 64 |
Total number of gains: 20; Total number of losses: 96; Total Number of normals: 372.
Somatic mutations of LHPP:
Generating mutation plots.
Highly correlated genes for LHPP:
Showing top 20/681 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LHPP | SLC46A2 | 0.695414 | 4 | 0 | 4 |
| LHPP | ACOX3 | 0.688353 | 8 | 0 | 7 |
| LHPP | LINC01210 | 0.681764 | 3 | 0 | 3 |
| LHPP | B3GALT4 | 0.678898 | 7 | 0 | 7 |
| LHPP | TM4SF4 | 0.677377 | 3 | 0 | 3 |
| LHPP | SAMD10 | 0.671576 | 3 | 0 | 3 |
| LHPP | NCCRP1 | 0.668582 | 3 | 0 | 3 |
| LHPP | CES2 | 0.66653 | 7 | 0 | 7 |
| LHPP | HES5 | 0.664063 | 3 | 0 | 3 |
| LHPP | VSIG2 | 0.663737 | 6 | 0 | 6 |
| LHPP | TPCN1 | 0.660292 | 8 | 0 | 8 |
| LHPP | SPSB3 | 0.660005 | 11 | 0 | 10 |
| LHPP | SLC13A4 | 0.65845 | 8 | 0 | 7 |
| LHPP | ARHGEF10L | 0.657543 | 9 | 0 | 8 |
| LHPP | IL12A-AS1 | 0.656851 | 4 | 0 | 4 |
| LHPP | CLOCK | 0.653735 | 9 | 0 | 9 |
| LHPP | BLOC1S1 | 0.653481 | 10 | 0 | 8 |
| LHPP | PWWP2B | 0.652351 | 5 | 0 | 4 |
| LHPP | MRPS36 | 0.651126 | 5 | 0 | 4 |
| LHPP | ALS2CL | 0.647803 | 10 | 0 | 9 |
For details and further investigation, click here
