LOXL1

 

Full name: lysyl oxidase like 1 Alias Symbol: LOXL|LOL
Type: protein-coding gene Cytoband: 15q24.1
Entrez ID: 4016 HGNC ID: HGNC:6665 Ensembl Gene: ENSG00000129038 OMIM ID: 153456
Drug and gene relationship at DGIdb

 

Expression of LOXL1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 LOXL1 4016 203570_at 0.5202 0.5862
GSE20347 LOXL1 4016 203570_at 1.3583 0.0001
GSE23400 LOXL1 4016 203570_at 0.8062 0.0000
GSE26886 LOXL1 4016 203570_at 1.9768 0.0000
GSE29001 LOXL1 4016 203570_at 0.5936 0.0397
GSE38129 LOXL1 4016 203570_at 1.1057 0.0018
GSE45670 LOXL1 4016 203570_at -0.3964 0.4292
GSE53622 LOXL1 4016 138966 1.2075 0.0000
GSE53624 LOXL1 4016 138966 1.3285 0.0000
GSE63941 LOXL1 4016 203570_at -3.0480 0.0385
GSE77861 LOXL1 4016 203570_at 0.8851 0.0081
GSE97050 LOXL1 4016 A_33_P3354464 0.6789 0.1726
SRP007169 LOXL1 4016 RNAseq 1.7053 0.0004
SRP008496 LOXL1 4016 RNAseq 2.4721 0.0000
SRP064894 LOXL1 4016 RNAseq 1.2011 0.0008
SRP133303 LOXL1 4016 RNAseq 1.7078 0.0000
SRP159526 LOXL1 4016 RNAseq 1.0869 0.0017
SRP193095 LOXL1 4016 RNAseq 1.3872 0.0000
SRP219564 LOXL1 4016 RNAseq 0.8763 0.2007
TCGA LOXL1 4016 RNAseq 0.1107 0.3115

Upregulated datasets: 11; Downregulated datasets: 1.  

 

Survival by LOXL1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of LOXL1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 LOXL1 4016 8 0 22
GSE20123 LOXL1 4016 8 0 22
GSE43470 LOXL1 4016 4 6 33
GSE46452 LOXL1 4016 3 7 49
GSE47630 LOXL1 4016 8 10 22
GSE54993 LOXL1 4016 5 6 59
GSE54994 LOXL1 4016 5 7 41
GSE60625 LOXL1 4016 4 0 7
GSE74703 LOXL1 4016 4 3 29
GSE74704 LOXL1 4016 4 0 16
TCGA LOXL1 4016 13 15 68

Total number of gains: 66; Total number of losses: 54; Total Number of normals: 368.  

 

Somatic mutations of LOXL1:

 

Generating mutation plots.

 

Highly correlated genes for LOXL1:

 

Showing top 20/1335 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
LOXL1SCYL10.766778303
LOXL1RAB340.759637303
LOXL1TIMP10.75287912012
LOXL1AZIN20.752524303
LOXL1GRAMD1A0.746372707
LOXL1VCAN0.74538313013
LOXL1FSTL10.74049313013
LOXL1ALKBH60.738716303
LOXL1FNDC10.736074807
LOXL1SPARC0.73378713012
LOXL1COL6A30.73319913013
LOXL1FKBP70.7245707
LOXL1NCOR20.723182807
LOXL1MXRA80.72116612012
LOXL1LUM0.71741613012
LOXL1COL6A20.71649112011
LOXL1PCOLCE0.71523413012
LOXL1HTRA10.71495413012
LOXL1FADS10.71393303
LOXL1CTSK0.7137913012

For details and further investigation, click here