PCOLCE

 

Full name: procollagen C-endopeptidase enhancer Alias Symbol: PCPE|PCPE1
Type: protein-coding gene Cytoband: 7q22.1
Entrez ID: 5118 HGNC ID: HGNC:8738 Ensembl Gene: ENSG00000106333 OMIM ID: 600270
Drug and gene relationship at DGIdb

 

Expression of PCOLCE:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PCOLCE 5118 202465_at 0.4324 0.6515
GSE20347 PCOLCE 5118 202465_at 1.1096 0.0000
GSE23400 PCOLCE 5118 202465_at 0.4988 0.0000
GSE26886 PCOLCE 5118 202465_at 1.5304 0.0001
GSE29001 PCOLCE 5118 202465_at 0.6757 0.0214
GSE38129 PCOLCE 5118 202465_at 0.8581 0.0047
GSE45670 PCOLCE 5118 202465_at -0.4403 0.3413
GSE53622 PCOLCE 5118 118387 1.2900 0.0000
GSE53624 PCOLCE 5118 118387 1.5661 0.0000
GSE63941 PCOLCE 5118 202465_at -3.6711 0.0000
GSE77861 PCOLCE 5118 202465_at 0.5089 0.2032
GSE97050 PCOLCE 5118 A_23_P251499 1.3866 0.0781
SRP007169 PCOLCE 5118 RNAseq 3.0941 0.0000
SRP008496 PCOLCE 5118 RNAseq 3.5028 0.0000
SRP064894 PCOLCE 5118 RNAseq 1.6611 0.0004
SRP133303 PCOLCE 5118 RNAseq 1.4625 0.0008
SRP159526 PCOLCE 5118 RNAseq 0.3507 0.3269
SRP193095 PCOLCE 5118 RNAseq 2.8300 0.0000
SRP219564 PCOLCE 5118 RNAseq 1.8221 0.0058
TCGA PCOLCE 5118 RNAseq 0.1888 0.1396

Upregulated datasets: 10; Downregulated datasets: 1.  

 

Survival by PCOLCE expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PCOLCE:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PCOLCE 5118 13 0 17
GSE20123 PCOLCE 5118 13 0 17
GSE43470 PCOLCE 5118 7 2 34
GSE46452 PCOLCE 5118 11 1 47
GSE47630 PCOLCE 5118 7 3 30
GSE54993 PCOLCE 5118 1 9 60
GSE54994 PCOLCE 5118 16 3 34
GSE60625 PCOLCE 5118 0 0 11
GSE74703 PCOLCE 5118 7 1 28
GSE74704 PCOLCE 5118 9 0 11
TCGA PCOLCE 5118 53 6 37

Total number of gains: 137; Total number of losses: 25; Total Number of normals: 326.  

 

Somatic mutations of PCOLCE:

 

Generating mutation plots.

 

Highly correlated genes for PCOLCE:

 

Showing top 20/1149 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PCOLCECTSK0.87041713013
PCOLCECOL6A30.85493113013
PCOLCETHY10.84777913013
PCOLCEVCAN0.83293413013
PCOLCECOL5A10.82707913013
PCOLCEPDGFRB0.82561813012
PCOLCEOLFML2B0.82067313013
PCOLCESPARC0.81912813013
PCOLCEISLR0.81411813013
PCOLCEMMP20.81063812011
PCOLCECOL6A10.80371413013
PCOLCECOL8A10.79405410010
PCOLCEFAP0.7877211011
PCOLCECHN10.78705713013
PCOLCEDNM3OS0.786656303
PCOLCECOL3A10.78168913013
PCOLCEAEBP10.78125913013
PCOLCEFNDC10.778058909
PCOLCECOL6A20.77447713013
PCOLCEPOSTN0.77389313013

For details and further investigation, click here