CTSK

 

Full name: cathepsin K Alias Symbol: PKND
Type: protein-coding gene Cytoband: 1q21.3
Entrez ID: 1513 HGNC ID: HGNC:2536 Ensembl Gene: ENSG00000143387 OMIM ID: 601105
Drug and gene relationship at DGIdb

 

CTSK involved pathways:

KEGG pathway Description View
hsa04210Apoptosis

 

Expression of CTSK:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CTSK 1513 202450_s_at 0.3390 0.8107
GSE20347 CTSK 1513 202450_s_at 1.7476 0.0000
GSE23400 CTSK 1513 202450_s_at 0.9225 0.0000
GSE26886 CTSK 1513 202450_s_at 1.4268 0.0309
GSE29001 CTSK 1513 202450_s_at 0.8054 0.0020
GSE38129 CTSK 1513 202450_s_at 1.4439 0.0002
GSE45670 CTSK 1513 202450_s_at -0.4721 0.4155
GSE53622 CTSK 1513 53501 1.8127 0.0000
GSE53624 CTSK 1513 33916 1.8298 0.0000
GSE63941 CTSK 1513 202450_s_at -7.1889 0.0000
GSE77861 CTSK 1513 202450_s_at 0.9131 0.0886
GSE97050 CTSK 1513 A_23_P34744 1.5250 0.0835
SRP007169 CTSK 1513 RNAseq 4.1193 0.0000
SRP008496 CTSK 1513 RNAseq 4.3844 0.0000
SRP064894 CTSK 1513 RNAseq 2.1207 0.0000
SRP133303 CTSK 1513 RNAseq 2.1837 0.0000
SRP159526 CTSK 1513 RNAseq 1.1541 0.0069
SRP193095 CTSK 1513 RNAseq 3.0821 0.0000
SRP219564 CTSK 1513 RNAseq 1.7155 0.0064
TCGA CTSK 1513 RNAseq 0.2347 0.0711

Upregulated datasets: 12; Downregulated datasets: 1.  

 

Survival by CTSK expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CTSK:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CTSK 1513 15 0 15
GSE20123 CTSK 1513 15 0 15
GSE43470 CTSK 1513 6 1 36
GSE46452 CTSK 1513 2 1 56
GSE47630 CTSK 1513 14 0 26
GSE54993 CTSK 1513 0 3 67
GSE54994 CTSK 1513 15 0 38
GSE60625 CTSK 1513 0 0 11
GSE74703 CTSK 1513 6 1 29
GSE74704 CTSK 1513 7 0 13
TCGA CTSK 1513 37 2 57

Total number of gains: 117; Total number of losses: 8; Total Number of normals: 363.  

 

Somatic mutations of CTSK:

 

Generating mutation plots.

 

Highly correlated genes for CTSK:

 

Showing top 20/1034 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CTSKCOL6A30.88552213013
CTSKPCOLCE0.87041713013
CTSKVCAN0.8627813013
CTSKSPARC0.85657613013
CTSKCOL1A20.85356612012
CTSKLUM0.83021613013
CTSKCOL3A10.82627113013
CTSKPDGFRB0.82487212012
CTSKMMP20.82226112011
CTSKPOSTN0.81520313013
CTSKFAP0.81370111011
CTSKTHY10.81130113013
CTSKCOL5A20.80858413013
CTSKSULF10.80788213013
CTSKFNDC10.802011909
CTSKCDH110.79598613012
CTSKCHN10.79288413013
CTSKCOL12A10.792429909
CTSKCOL6A20.79173212012
CTSKOLFML2B0.79002813013

For details and further investigation, click here