| Full name: collagen type VI alpha 2 chain | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 1292 | HGNC ID: HGNC:2212 | Ensembl Gene: ENSG00000142173 | OMIM ID: 120240 |
| Drug and gene relationship at DGIdb | |||
COL6A2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion |
Expression of COL6A2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COL6A2 | 1292 | 209156_s_at | 0.0834 | 0.9529 | |
| GSE20347 | COL6A2 | 1292 | 209156_s_at | 1.0715 | 0.0102 | |
| GSE23400 | COL6A2 | 1292 | 209156_s_at | 0.5108 | 0.0335 | |
| GSE26886 | COL6A2 | 1292 | 209156_s_at | 2.0141 | 0.0004 | |
| GSE29001 | COL6A2 | 1292 | 213290_at | 0.1067 | 0.6383 | |
| GSE38129 | COL6A2 | 1292 | 209156_s_at | 0.6337 | 0.1601 | |
| GSE45670 | COL6A2 | 1292 | 209156_s_at | -0.5755 | 0.2182 | |
| GSE53622 | COL6A2 | 1292 | 70420 | 0.8589 | 0.0000 | |
| GSE53624 | COL6A2 | 1292 | 70420 | 1.1835 | 0.0000 | |
| GSE63941 | COL6A2 | 1292 | 209156_s_at | -2.4359 | 0.0042 | |
| GSE77861 | COL6A2 | 1292 | 209156_s_at | 1.6762 | 0.0213 | |
| GSE97050 | COL6A2 | 1292 | A_33_P3269539 | 0.6507 | 0.2421 | |
| SRP007169 | COL6A2 | 1292 | RNAseq | 2.7980 | 0.0000 | |
| SRP008496 | COL6A2 | 1292 | RNAseq | 3.1292 | 0.0000 | |
| SRP064894 | COL6A2 | 1292 | RNAseq | 1.2647 | 0.0001 | |
| SRP133303 | COL6A2 | 1292 | RNAseq | 1.0516 | 0.0071 | |
| SRP159526 | COL6A2 | 1292 | RNAseq | -0.0138 | 0.9656 | |
| SRP193095 | COL6A2 | 1292 | RNAseq | 2.6889 | 0.0000 | |
| SRP219564 | COL6A2 | 1292 | RNAseq | 0.3730 | 0.6055 | |
| TCGA | COL6A2 | 1292 | RNAseq | 0.0094 | 0.9185 |
Upregulated datasets: 9; Downregulated datasets: 1.
Survival by COL6A2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of COL6A2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COL6A2 | 1292 | 3 | 9 | 18 | |
| GSE20123 | COL6A2 | 1292 | 3 | 9 | 18 | |
| GSE43470 | COL6A2 | 1292 | 0 | 14 | 29 | |
| GSE46452 | COL6A2 | 1292 | 1 | 21 | 37 | |
| GSE47630 | COL6A2 | 1292 | 6 | 17 | 17 | |
| GSE54993 | COL6A2 | 1292 | 8 | 1 | 61 | |
| GSE54994 | COL6A2 | 1292 | 5 | 8 | 40 | |
| GSE60625 | COL6A2 | 1292 | 0 | 0 | 11 | |
| GSE74703 | COL6A2 | 1292 | 0 | 10 | 26 | |
| GSE74704 | COL6A2 | 1292 | 1 | 5 | 14 | |
| TCGA | COL6A2 | 1292 | 10 | 38 | 48 |
Total number of gains: 37; Total number of losses: 132; Total Number of normals: 319.
Somatic mutations of COL6A2:
Generating mutation plots.
Highly correlated genes for COL6A2:
Showing top 20/1266 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COL6A2 | COL6A1 | 0.916131 | 13 | 0 | 13 |
| COL6A2 | FN1 | 0.824289 | 11 | 0 | 11 |
| COL6A2 | DNM3OS | 0.82085 | 3 | 0 | 3 |
| COL6A2 | COL12A1 | 0.82047 | 9 | 0 | 9 |
| COL6A2 | ISLR | 0.81202 | 13 | 0 | 13 |
| COL6A2 | PDGFRB | 0.796975 | 12 | 0 | 12 |
| COL6A2 | AEBP1 | 0.79546 | 13 | 0 | 13 |
| COL6A2 | HTRA1 | 0.792103 | 12 | 0 | 12 |
| COL6A2 | CTSK | 0.791732 | 12 | 0 | 12 |
| COL6A2 | FBN1 | 0.784427 | 10 | 0 | 9 |
| COL6A2 | FSTL1 | 0.784045 | 12 | 0 | 12 |
| COL6A2 | ANGPTL2 | 0.782864 | 13 | 0 | 13 |
| COL6A2 | EFEMP2 | 0.782182 | 13 | 0 | 13 |
| COL6A2 | JMY | 0.779611 | 3 | 0 | 3 |
| COL6A2 | PCOLCE | 0.774477 | 13 | 0 | 13 |
| COL6A2 | COL6A3 | 0.774198 | 13 | 0 | 12 |
| COL6A2 | SPARC | 0.769257 | 13 | 0 | 12 |
| COL6A2 | COL5A1 | 0.762723 | 13 | 0 | 12 |
| COL6A2 | COL3A1 | 0.76243 | 11 | 0 | 11 |
| COL6A2 | MXRA8 | 0.762077 | 13 | 0 | 13 |
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