| Full name: lipoprotein lipase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8p21.3 | ||
| Entrez ID: 4023 | HGNC ID: HGNC:6677 | Ensembl Gene: ENSG00000175445 | OMIM ID: 609708 |
| Drug and gene relationship at DGIdb | |||
LPL involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway | |
| hsa05010 | Alzheimer's disease |
Expression of LPL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LPL | 4023 | 203549_s_at | 0.5196 | 0.7019 | |
| GSE20347 | LPL | 4023 | 203549_s_at | 0.4213 | 0.0047 | |
| GSE23400 | LPL | 4023 | 203549_s_at | 0.0522 | 0.5900 | |
| GSE26886 | LPL | 4023 | 203549_s_at | 0.8270 | 0.0208 | |
| GSE29001 | LPL | 4023 | 203549_s_at | 0.7853 | 0.0588 | |
| GSE38129 | LPL | 4023 | 203549_s_at | -0.0863 | 0.8593 | |
| GSE45670 | LPL | 4023 | 203549_s_at | -0.1009 | 0.7617 | |
| GSE53622 | LPL | 4023 | 29794 | 1.2302 | 0.0000 | |
| GSE53624 | LPL | 4023 | 29794 | 1.8359 | 0.0000 | |
| GSE63941 | LPL | 4023 | 203549_s_at | 0.2613 | 0.7997 | |
| GSE77861 | LPL | 4023 | 203549_s_at | -0.0629 | 0.7182 | |
| GSE97050 | LPL | 4023 | A_23_P146233 | 0.0919 | 0.8378 | |
| SRP064894 | LPL | 4023 | RNAseq | 3.9156 | 0.0000 | |
| SRP133303 | LPL | 4023 | RNAseq | 2.4405 | 0.0000 | |
| SRP159526 | LPL | 4023 | RNAseq | 1.8150 | 0.0000 | |
| SRP193095 | LPL | 4023 | RNAseq | 0.7199 | 0.0889 | |
| SRP219564 | LPL | 4023 | RNAseq | -0.1260 | 0.9028 | |
| TCGA | LPL | 4023 | RNAseq | -0.1438 | 0.5350 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by LPL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LPL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LPL | 4023 | 4 | 10 | 16 | |
| GSE20123 | LPL | 4023 | 4 | 10 | 16 | |
| GSE43470 | LPL | 4023 | 4 | 8 | 31 | |
| GSE46452 | LPL | 4023 | 14 | 13 | 32 | |
| GSE47630 | LPL | 4023 | 10 | 8 | 22 | |
| GSE54993 | LPL | 4023 | 2 | 14 | 54 | |
| GSE54994 | LPL | 4023 | 8 | 18 | 27 | |
| GSE60625 | LPL | 4023 | 3 | 0 | 8 | |
| GSE74703 | LPL | 4023 | 4 | 7 | 25 | |
| GSE74704 | LPL | 4023 | 3 | 6 | 11 | |
| TCGA | LPL | 4023 | 14 | 42 | 40 |
Total number of gains: 70; Total number of losses: 136; Total Number of normals: 282.
Somatic mutations of LPL:
Generating mutation plots.
Highly correlated genes for LPL:
Showing top 20/730 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LPL | FAM13A | 0.717462 | 3 | 0 | 3 |
| LPL | RTN3 | 0.699637 | 3 | 0 | 3 |
| LPL | RAB34 | 0.69483 | 3 | 0 | 3 |
| LPL | RASSF4 | 0.688008 | 3 | 0 | 3 |
| LPL | C1orf198 | 0.686548 | 5 | 0 | 5 |
| LPL | FCGR3A | 0.683052 | 3 | 0 | 3 |
| LPL | HRH1 | 0.679739 | 3 | 0 | 3 |
| LPL | ICAM1 | 0.677873 | 4 | 0 | 4 |
| LPL | RNASE4 | 0.676448 | 4 | 0 | 3 |
| LPL | ITGA11 | 0.675903 | 3 | 0 | 3 |
| LPL | GNB4 | 0.672723 | 4 | 0 | 3 |
| LPL | FKBP10 | 0.671561 | 5 | 0 | 4 |
| LPL | PDGFRL | 0.668844 | 10 | 0 | 7 |
| LPL | MMD | 0.665339 | 10 | 0 | 8 |
| LPL | CHN1 | 0.654703 | 10 | 0 | 8 |
| LPL | DENND5B | 0.652873 | 5 | 0 | 4 |
| LPL | GXYLT2 | 0.651946 | 5 | 0 | 4 |
| LPL | CLMP | 0.650545 | 5 | 0 | 5 |
| LPL | RGS3 | 0.650457 | 9 | 0 | 8 |
| LPL | SLC12A4 | 0.649457 | 6 | 0 | 6 |
For details and further investigation, click here
