| Full name: LDL receptor related protein 1B | Alias Symbol: LRP-DIT|LRPDIT | ||
| Type: protein-coding gene | Cytoband: 2q22.1-q22.2 | ||
| Entrez ID: 53353 | HGNC ID: HGNC:6693 | Ensembl Gene: ENSG00000168702 | OMIM ID: 608766 |
| Drug and gene relationship at DGIdb | |||
Expression of LRP1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRP1B | 53353 | 219643_at | 0.1708 | 0.4079 | |
| GSE20347 | LRP1B | 53353 | 219643_at | -0.0020 | 0.9784 | |
| GSE23400 | LRP1B | 53353 | 219643_at | -0.0140 | 0.5243 | |
| GSE26886 | LRP1B | 53353 | 219643_at | 0.5011 | 0.1747 | |
| GSE29001 | LRP1B | 53353 | 219643_at | 0.1773 | 0.5737 | |
| GSE38129 | LRP1B | 53353 | 219643_at | 0.0128 | 0.9248 | |
| GSE45670 | LRP1B | 53353 | 219643_at | 0.1507 | 0.6268 | |
| GSE53622 | LRP1B | 53353 | 6355 | -0.1679 | 0.1359 | |
| GSE53624 | LRP1B | 53353 | 6355 | -0.1139 | 0.3452 | |
| GSE63941 | LRP1B | 53353 | 219643_at | 0.1527 | 0.7477 | |
| GSE77861 | LRP1B | 53353 | 219643_at | -0.0629 | 0.3580 | |
| SRP133303 | LRP1B | 53353 | RNAseq | -0.9513 | 0.1216 | |
| SRP159526 | LRP1B | 53353 | RNAseq | 1.6522 | 0.0041 | |
| TCGA | LRP1B | 53353 | RNAseq | -0.6489 | 0.3430 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by LRP1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRP1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRP1B | 53353 | 1 | 15 | 14 | |
| GSE20123 | LRP1B | 53353 | 1 | 14 | 15 | |
| GSE43470 | LRP1B | 53353 | 4 | 9 | 30 | |
| GSE46452 | LRP1B | 53353 | 1 | 4 | 54 | |
| GSE47630 | LRP1B | 53353 | 3 | 6 | 31 | |
| GSE54993 | LRP1B | 53353 | 3 | 5 | 62 | |
| GSE54994 | LRP1B | 53353 | 9 | 11 | 33 | |
| GSE60625 | LRP1B | 53353 | 0 | 3 | 8 | |
| GSE74703 | LRP1B | 53353 | 3 | 8 | 25 | |
| GSE74704 | LRP1B | 53353 | 1 | 9 | 10 | |
| TCGA | LRP1B | 53353 | 18 | 52 | 26 |
Total number of gains: 44; Total number of losses: 136; Total Number of normals: 308.
Somatic mutations of LRP1B:
Generating mutation plots.
Highly correlated genes for LRP1B:
Showing top 20/23 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRP1B | TMTC4 | 0.655096 | 3 | 0 | 3 |
| LRP1B | ZNF470 | 0.653321 | 3 | 0 | 3 |
| LRP1B | FOXC1 | 0.638809 | 3 | 0 | 3 |
| LRP1B | SETDB1 | 0.633308 | 3 | 0 | 3 |
| LRP1B | ZNF232 | 0.623918 | 3 | 0 | 3 |
| LRP1B | TUBB2B | 0.60323 | 4 | 0 | 3 |
| LRP1B | ZNF74 | 0.602114 | 3 | 0 | 3 |
| LRP1B | PRR3 | 0.591676 | 4 | 0 | 3 |
| LRP1B | FAM201A | 0.577124 | 3 | 0 | 3 |
| LRP1B | ACTL8 | 0.576776 | 3 | 0 | 3 |
| LRP1B | RLN2 | 0.569753 | 3 | 0 | 3 |
| LRP1B | MEGF8 | 0.563457 | 3 | 0 | 3 |
| LRP1B | ZNF77 | 0.555287 | 4 | 0 | 3 |
| LRP1B | GSDMB | 0.554837 | 3 | 0 | 3 |
| LRP1B | EGF | 0.546668 | 5 | 0 | 3 |
| LRP1B | IDO2 | 0.542481 | 3 | 0 | 3 |
| LRP1B | COLGALT2 | 0.537826 | 5 | 0 | 3 |
| LRP1B | GPR63 | 0.537363 | 4 | 0 | 3 |
| LRP1B | ESRRG | 0.535816 | 4 | 0 | 3 |
| LRP1B | TMEM116 | 0.525413 | 4 | 0 | 3 |
For details and further investigation, click here
