| Full name: FtsJ RNA 2'-O-methyltransferase 3 | Alias Symbol: SPB1 | ||
| Type: protein-coding gene | Cytoband: 17q23.3 | ||
| Entrez ID: 117246 | HGNC ID: HGNC:17136 | Ensembl Gene: ENSG00000108592 | OMIM ID: 618411 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of FTSJ3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FTSJ3 | 117246 | 218103_at | 0.1859 | 0.3512 | |
| GSE20347 | FTSJ3 | 117246 | 218103_at | 0.3414 | 0.0085 | |
| GSE23400 | FTSJ3 | 117246 | 218103_at | 0.2782 | 0.0000 | |
| GSE26886 | FTSJ3 | 117246 | 218103_at | 0.7487 | 0.0004 | |
| GSE29001 | FTSJ3 | 117246 | 218103_at | 0.4837 | 0.0771 | |
| GSE38129 | FTSJ3 | 117246 | 218103_at | 0.3455 | 0.0036 | |
| GSE45670 | FTSJ3 | 117246 | 218103_at | 0.4336 | 0.0045 | |
| GSE53622 | FTSJ3 | 117246 | 65132 | 0.2289 | 0.0000 | |
| GSE53624 | FTSJ3 | 117246 | 65132 | 0.5865 | 0.0000 | |
| GSE63941 | FTSJ3 | 117246 | 218103_at | 0.0484 | 0.9085 | |
| GSE77861 | FTSJ3 | 117246 | 218103_at | 0.6648 | 0.0103 | |
| GSE97050 | FTSJ3 | 117246 | A_23_P55091 | 0.0666 | 0.7992 | |
| SRP007169 | FTSJ3 | 117246 | RNAseq | 1.0569 | 0.0300 | |
| SRP008496 | FTSJ3 | 117246 | RNAseq | 0.9276 | 0.0041 | |
| SRP064894 | FTSJ3 | 117246 | RNAseq | 0.7138 | 0.0000 | |
| SRP133303 | FTSJ3 | 117246 | RNAseq | 0.5731 | 0.0011 | |
| SRP159526 | FTSJ3 | 117246 | RNAseq | 0.6278 | 0.0125 | |
| SRP193095 | FTSJ3 | 117246 | RNAseq | 0.4221 | 0.0002 | |
| SRP219564 | FTSJ3 | 117246 | RNAseq | 0.4130 | 0.2632 | |
| TCGA | FTSJ3 | 117246 | RNAseq | 0.0617 | 0.2070 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by FTSJ3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FTSJ3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FTSJ3 | 117246 | 3 | 1 | 26 | |
| GSE20123 | FTSJ3 | 117246 | 3 | 1 | 26 | |
| GSE43470 | FTSJ3 | 117246 | 4 | 0 | 39 | |
| GSE46452 | FTSJ3 | 117246 | 31 | 0 | 28 | |
| GSE47630 | FTSJ3 | 117246 | 7 | 1 | 32 | |
| GSE54993 | FTSJ3 | 117246 | 2 | 5 | 63 | |
| GSE54994 | FTSJ3 | 117246 | 9 | 4 | 40 | |
| GSE60625 | FTSJ3 | 117246 | 4 | 0 | 7 | |
| GSE74703 | FTSJ3 | 117246 | 4 | 0 | 32 | |
| GSE74704 | FTSJ3 | 117246 | 3 | 1 | 16 | |
| TCGA | FTSJ3 | 117246 | 31 | 9 | 56 |
Total number of gains: 101; Total number of losses: 22; Total Number of normals: 365.
Somatic mutations of FTSJ3:
Generating mutation plots.
Highly correlated genes for FTSJ3:
Showing top 20/1693 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FTSJ3 | ALKBH6 | 0.810179 | 4 | 0 | 4 |
| FTSJ3 | KIF16B | 0.786064 | 3 | 0 | 3 |
| FTSJ3 | THAP4 | 0.766526 | 3 | 0 | 3 |
| FTSJ3 | LSR | 0.764358 | 3 | 0 | 3 |
| FTSJ3 | RHBDD2 | 0.735964 | 4 | 0 | 4 |
| FTSJ3 | TRMT2A | 0.73534 | 3 | 0 | 3 |
| FTSJ3 | DCAF7 | 0.728436 | 5 | 0 | 4 |
| FTSJ3 | PLEKHA3 | 0.725356 | 3 | 0 | 3 |
| FTSJ3 | BIRC3 | 0.721949 | 3 | 0 | 3 |
| FTSJ3 | TMEM63B | 0.720499 | 3 | 0 | 3 |
| FTSJ3 | LRP4 | 0.719368 | 4 | 0 | 4 |
| FTSJ3 | WDR54 | 0.716632 | 7 | 0 | 6 |
| FTSJ3 | ZCCHC3 | 0.714353 | 4 | 0 | 3 |
| FTSJ3 | CD44 | 0.713932 | 3 | 0 | 3 |
| FTSJ3 | F2RL1 | 0.71353 | 3 | 0 | 3 |
| FTSJ3 | AGTRAP | 0.712968 | 3 | 0 | 3 |
| FTSJ3 | ZNF18 | 0.703338 | 4 | 0 | 3 |
| FTSJ3 | NEK3 | 0.703319 | 3 | 0 | 3 |
| FTSJ3 | PET117 | 0.698356 | 4 | 0 | 4 |
| FTSJ3 | FARS2 | 0.69733 | 3 | 0 | 3 |
For details and further investigation, click here
