LRPPRC

 

Full name: leucine rich pentatricopeptide repeat containing Alias Symbol: GP130|LRP130
Type: protein-coding gene Cytoband: 2p21
Entrez ID: 10128 HGNC ID: HGNC:15714 Ensembl Gene: ENSG00000138095 OMIM ID: 607544
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of LRPPRC:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 LRPPRC 10128 211971_s_at 0.4618 0.0553
GSE20347 LRPPRC 10128 211971_s_at 0.6439 0.0001
GSE23400 LRPPRC 10128 211971_s_at 0.6912 0.0000
GSE26886 LRPPRC 10128 211615_s_at 0.3997 0.0137
GSE29001 LRPPRC 10128 211615_s_at 0.3481 0.1670
GSE38129 LRPPRC 10128 211971_s_at 0.7331 0.0000
GSE45670 LRPPRC 10128 211971_s_at 0.3880 0.0091
GSE53622 LRPPRC 10128 30372 0.4675 0.0000
GSE53624 LRPPRC 10128 30372 0.5756 0.0000
GSE63941 LRPPRC 10128 211971_s_at 1.0277 0.0100
GSE77861 LRPPRC 10128 211971_s_at 0.5757 0.0542
GSE97050 LRPPRC 10128 A_33_P3388855 0.4540 0.2662
SRP007169 LRPPRC 10128 RNAseq 1.4906 0.0001
SRP008496 LRPPRC 10128 RNAseq 1.3442 0.0000
SRP064894 LRPPRC 10128 RNAseq 0.1499 0.3028
SRP133303 LRPPRC 10128 RNAseq 0.3614 0.0282
SRP159526 LRPPRC 10128 RNAseq 0.5985 0.0462
SRP193095 LRPPRC 10128 RNAseq 0.2420 0.0252
SRP219564 LRPPRC 10128 RNAseq 0.2792 0.3459
TCGA LRPPRC 10128 RNAseq 0.0705 0.0879

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by LRPPRC expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of LRPPRC:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 LRPPRC 10128 10 1 19
GSE20123 LRPPRC 10128 9 1 20
GSE43470 LRPPRC 10128 4 0 39
GSE46452 LRPPRC 10128 1 4 54
GSE47630 LRPPRC 10128 7 0 33
GSE54993 LRPPRC 10128 0 5 65
GSE54994 LRPPRC 10128 10 0 43
GSE60625 LRPPRC 10128 0 3 8
GSE74703 LRPPRC 10128 4 0 32
GSE74704 LRPPRC 10128 9 1 10
TCGA LRPPRC 10128 35 2 59

Total number of gains: 89; Total number of losses: 17; Total Number of normals: 382.  

 

Somatic mutations of LRPPRC:

 

Generating mutation plots.

 

Highly correlated genes for LRPPRC:

 

Showing top 20/1444 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
LRPPRCPDIA60.725651009
LRPPRCTRMT61B0.72372110010
LRPPRCCCT40.71455913012
LRPPRCNUP930.714369909
LRPPRCPNPT10.71161707
LRPPRCDAP30.70279412011
LRPPRCHSPE10.70111811010
LRPPRCRFC40.69995912011
LRPPRCHSPD10.69637712011
LRPPRCPTCD30.69632512011
LRPPRCXPO10.69566913012
LRPPRCILF20.6944812011
LRPPRCPRKDC0.6937612011
LRPPRCKIF230.69358211011
LRPPRCCAD0.69219113012
LRPPRCPSME40.69027512011
LRPPRCNOL110.68975313012
LRPPRCCOX7A2L0.68931212011
LRPPRCPSMA40.684792909
LRPPRCNDUFAF70.68438110010

For details and further investigation, click here