NUP93

 

Full name: nucleoporin 93 Alias Symbol: KIAA0095
Type: protein-coding gene Cytoband: 16q13
Entrez ID: 9688 HGNC ID: HGNC:28958 Ensembl Gene: ENSG00000102900 OMIM ID: 614351
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 271/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of NUP93:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NUP93 9688 202188_at 0.6082 0.1783
GSE20347 NUP93 9688 202188_at 0.7157 0.0011
GSE23400 NUP93 9688 202188_at 0.4785 0.0000
GSE26886 NUP93 9688 202188_at -0.0813 0.7600
GSE29001 NUP93 9688 202188_at 0.4961 0.2224
GSE38129 NUP93 9688 202188_at 0.9318 0.0000
GSE45670 NUP93 9688 202188_at 0.4778 0.0043
GSE53622 NUP93 9688 79873 0.7224 0.0000
GSE53624 NUP93 9688 79873 0.7222 0.0000
GSE63941 NUP93 9688 202188_at 0.4342 0.3518
GSE77861 NUP93 9688 202188_at 0.5736 0.0298
GSE97050 NUP93 9688 A_23_P89056 0.5355 0.1723
SRP007169 NUP93 9688 RNAseq 1.9727 0.0000
SRP008496 NUP93 9688 RNAseq 1.6529 0.0000
SRP064894 NUP93 9688 RNAseq 0.6032 0.0000
SRP133303 NUP93 9688 RNAseq 0.7260 0.0003
SRP159526 NUP93 9688 RNAseq 0.7726 0.0101
SRP193095 NUP93 9688 RNAseq 0.4182 0.0004
SRP219564 NUP93 9688 RNAseq 0.6995 0.0071
TCGA NUP93 9688 RNAseq 0.3220 0.0000

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by NUP93 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NUP93:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NUP93 9688 5 0 25
GSE20123 NUP93 9688 5 1 24
GSE43470 NUP93 9688 2 7 34
GSE46452 NUP93 9688 38 1 20
GSE47630 NUP93 9688 10 8 22
GSE54993 NUP93 9688 2 4 64
GSE54994 NUP93 9688 7 10 36
GSE60625 NUP93 9688 4 0 7
GSE74703 NUP93 9688 2 4 30
GSE74704 NUP93 9688 4 0 16
TCGA NUP93 9688 25 13 58

Total number of gains: 104; Total number of losses: 48; Total Number of normals: 336.  

 

Somatic mutations of NUP93:

 

Generating mutation plots.

 

Highly correlated genes for NUP93:

 

Showing top 20/1573 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NUP93NOB10.762757404
NUP93EMC80.750991009
NUP93TPX20.74962211010
NUP93ILF20.7469410010
NUP93DKC10.744807303
NUP93CDK40.74342610010
NUP93UBE2T0.740275706
NUP93RUVBL10.73899712010
NUP93RANBP10.7332311010
NUP93CENPN0.73100212011
NUP93KIF26B0.725176303
NUP93CDT10.72440912011
NUP93CMSS10.723606505
NUP93GINS20.72273211010
NUP93CAD0.72205811010
NUP93EME10.719114504
NUP93RFC40.71791211010
NUP93SNRPB0.71573711010
NUP93LRPPRC0.714369909
NUP93XPO50.713387606

For details and further investigation, click here