| Full name: protein disulfide isomerase family A member 6 | Alias Symbol: P5|ERp5 | ||
| Type: protein-coding gene | Cytoband: 2p25.1 | ||
| Entrez ID: 10130 | HGNC ID: HGNC:30168 | Ensembl Gene: ENSG00000143870 | OMIM ID: 611099 |
| Drug and gene relationship at DGIdb | |||
Expression of PDIA6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDIA6 | 10130 | 207668_x_at | 0.9227 | 0.0581 | |
| GSE20347 | PDIA6 | 10130 | 207668_x_at | 0.6506 | 0.0065 | |
| GSE23400 | PDIA6 | 10130 | 208639_x_at | 0.8635 | 0.0000 | |
| GSE26886 | PDIA6 | 10130 | 208639_x_at | -0.2542 | 0.2062 | |
| GSE29001 | PDIA6 | 10130 | 207668_x_at | 1.1571 | 0.0023 | |
| GSE38129 | PDIA6 | 10130 | 207668_x_at | 0.9191 | 0.0000 | |
| GSE45670 | PDIA6 | 10130 | 207668_x_at | 0.6606 | 0.0003 | |
| GSE53622 | PDIA6 | 10130 | 73983 | 0.8750 | 0.0000 | |
| GSE53624 | PDIA6 | 10130 | 73983 | 0.7811 | 0.0000 | |
| GSE63941 | PDIA6 | 10130 | 207668_x_at | -0.1155 | 0.8055 | |
| GSE77861 | PDIA6 | 10130 | 208639_x_at | 0.4922 | 0.0188 | |
| GSE97050 | PDIA6 | 10130 | A_24_P319715 | 1.1107 | 0.0841 | |
| SRP007169 | PDIA6 | 10130 | RNAseq | 0.2831 | 0.4013 | |
| SRP008496 | PDIA6 | 10130 | RNAseq | 0.4673 | 0.0768 | |
| SRP064894 | PDIA6 | 10130 | RNAseq | 0.8477 | 0.0000 | |
| SRP133303 | PDIA6 | 10130 | RNAseq | 0.9659 | 0.0000 | |
| SRP159526 | PDIA6 | 10130 | RNAseq | 1.0997 | 0.0000 | |
| SRP193095 | PDIA6 | 10130 | RNAseq | 0.4001 | 0.0125 | |
| SRP219564 | PDIA6 | 10130 | RNAseq | 1.1460 | 0.0136 | |
| TCGA | PDIA6 | 10130 | RNAseq | 0.0638 | 0.1200 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by PDIA6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDIA6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDIA6 | 10130 | 11 | 2 | 17 | |
| GSE20123 | PDIA6 | 10130 | 11 | 2 | 17 | |
| GSE43470 | PDIA6 | 10130 | 2 | 1 | 40 | |
| GSE46452 | PDIA6 | 10130 | 3 | 4 | 52 | |
| GSE47630 | PDIA6 | 10130 | 7 | 0 | 33 | |
| GSE54993 | PDIA6 | 10130 | 0 | 7 | 63 | |
| GSE54994 | PDIA6 | 10130 | 11 | 0 | 42 | |
| GSE60625 | PDIA6 | 10130 | 0 | 3 | 8 | |
| GSE74703 | PDIA6 | 10130 | 2 | 0 | 34 | |
| GSE74704 | PDIA6 | 10130 | 9 | 1 | 10 | |
| TCGA | PDIA6 | 10130 | 34 | 5 | 57 |
Total number of gains: 90; Total number of losses: 25; Total Number of normals: 373.
Somatic mutations of PDIA6:
Generating mutation plots.
Highly correlated genes for PDIA6:
Showing top 20/1867 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDIA6 | CCT5 | 0.787415 | 8 | 0 | 8 |
| PDIA6 | CDCA2 | 0.762703 | 4 | 0 | 4 |
| PDIA6 | C1orf131 | 0.759979 | 6 | 0 | 6 |
| PDIA6 | EFTUD2 | 0.756906 | 6 | 0 | 6 |
| PDIA6 | CCT4 | 0.755723 | 10 | 0 | 9 |
| PDIA6 | BUB1 | 0.752782 | 8 | 0 | 8 |
| PDIA6 | NUF2 | 0.751942 | 6 | 0 | 6 |
| PDIA6 | PDIA4 | 0.74781 | 11 | 0 | 10 |
| PDIA6 | ILF2 | 0.747697 | 11 | 0 | 10 |
| PDIA6 | CKS1B | 0.746757 | 11 | 0 | 11 |
| PDIA6 | ECT2 | 0.746476 | 9 | 0 | 9 |
| PDIA6 | HSPD1 | 0.746279 | 10 | 0 | 10 |
| PDIA6 | BIRC3 | 0.745749 | 3 | 0 | 3 |
| PDIA6 | WDR81 | 0.743203 | 3 | 0 | 3 |
| PDIA6 | HAS3 | 0.741381 | 4 | 0 | 4 |
| PDIA6 | CLPTM1L | 0.741028 | 7 | 0 | 7 |
| PDIA6 | NME1 | 0.736125 | 10 | 0 | 9 |
| PDIA6 | MTHFD2 | 0.735484 | 10 | 0 | 10 |
| PDIA6 | SNRPE | 0.732888 | 10 | 0 | 10 |
| PDIA6 | MRPS28 | 0.730443 | 8 | 0 | 7 |
For details and further investigation, click here
